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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for HRK (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8739 Official gene symbol HRK Full name harakiri, BCL2 interacting protein (contains only BH3 domain) Aliases ,DP5,HARAKIRI, Gene summary Activator of apoptosis Hrk regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. [provided by RefSeq] Location Chromosome: 12   Locus: 12q24.22 Gene position 117319232 - 117299027  Map Viewer Gene orientation minus Gene size 20206 bp Gene sequence >HRK:complement(7875557..7895762):Length=20206 GAAACTTGGTGTCCAGGGGAGGCCCCCGGCGGCTGGAGCGCGGCGGCAGCGGGCGCAGAG GCCGGAGGGAGAGGAGGCGAGGGGCGGCCCGAGCGCGGGGCGGGAGCGAGGCCAGCGGTC ATGTGCCCGTGCCCCCTGCACCGCGGCCGCGGCCCCCCGGCCGTGTGCGCCTGCAGCGCG GGTCGCCTGGGGCTGCGCTCGTCCGCCGCGCAGCTCACCGCCGCCCGGCTCAAGGCGCTA GGCGACGAGCTGCACCAGCGCACCATGTGGCGGCGCCGCGCGCGGAGCCGGAGGGCGCCG GCGCCCGGCGCGCTCCCCACCTACTGGCCTTGGCTGTGCGCGGCCGCGCAGGTGGCGGCG CTGGCGGCCTGGCTGCTCGGCAGGCGGAACTTGTAGGAACGCGGGGCTTCTTGGTGGGGC CGGAGCCGAGACCCAGCCGGAGCGAGCAACAGGTACGCGAGCGAGCGAGCGAGAGCCGGG GCGCGGCAGCTGGGCACTGGAGACGCTGGGCTGGCCCGGGAGCGGGAGAGTGGCAAGTTT GGCTTTCTTCTTTTCCCTTCTCCTTCTTCCTCCGTTCTCTTCTCTTGCAAGCATCTCCAC CTCTCCTCTTCTACCCAGTCCCCAGTCTTCCCTTCCAAGTGTAAGGTCCACCGTTTCTGC CCCCATCTCTGCGAGTCCTTAAGCGCATCTTGCTACTCACTTATAGCTCAGTGGCTTGCG GAGGACTTCAGCCTCCATAATCCCCACCAGCCCCACAAATAAACACACAATGCAAGTAAA AAGTGTGCTTGCTATGGGAATGTAGTTGTAAGCCACGCCAAATACTTAAAATCTATCGCA CTTCCAAGAAAGGTCCCCGGTCCCGTTCCAATCCTCTTGCCGTTCCTGAGTCGCCCCCGT CTCCATCACCTTTGCTCCCAACCTCTTGTCCCTAAGTGTCACTTCTCCAATCTCTGATCC CCATTATCTGGCACCCCAAGCGCATCTCGAGACTTCCTCCCCCTCCAGGTTTCTGGCTGG CCCAATCTTTCTTCCCAAGCTCCGCGCATTTGCAATTTTCCTCTGCCCTGCCAACTTCGC TCCTTCTCGAGTGAGGTGTCCTGTTTAAGGAGTTTGGCTTCCTTCTCCCCAGACGGTTGT AGCTGCTACGGGAAGGAGACGCCCTCGGAGTGGGCTGGAATAGGGGGCTTTCAGGGAAAC TCCAATGGGAAGCCTTAAGGAAGGAACATTTATTGAGCTCCTTCGGGGTGCTGGGCACTG TTTAGGGAGGTCATGTGTTGAGAACTTAGGACAGGAAGTGGGTACTGAGCACCTAGTGTG GTTGGTATCAGTGGGAGGAAGGTACTAGGCTCTTGGGGTGGGGGGATCATTGTGCCCTAG CTGTGCGCCTGGCACTGTGCTAGGCGCTTTGAGGAAGCACACAGCGTAAGCATCGTCTTA CTACTCTGGATCCTGGAGTAGCGAGGAGCGCTGCAGAGAATGAGGGAGAGAGAATCAGGC TGAGCCCACCATAGATGGGTCTAGGGCCGGAAGGTGAAGCTCGAAGGTGACATAGCCAGC CGCCCTTAGGTCCCCGCCCCCGAGCCCCGCCGCGCGCCGCAGACACCCTGGGAAGTTGGA GCGGCGCCTGAAGGCGAGGCCCGAGCGTCTGCGCCCGCGGGGAAAGGCGGCAGCCGGAGC GTGGGGGGTGGCAGCGCCCAGGGAGCTGCGGGGGTGCGCGGGGTGTGAGCCGGGACCGCA GGCGACAGATGTCGCGTGGGCCCGCGCAGCCCGGGCGCTGGCGAAGAGAAATGCGCGCTT CGGGGCGCTCTCTGCCCGGCTCCCGGGCGCCGGGGGTCCCATCCACTTCTCCCTACCTTC TCTCTCTCCTGTTGGAGAGGCCAGGGGCTCCCGCGACTGAAAGGGGCCAGGCTGAGGCTG CCCAATCCCAGGGACAGGAAGAACATTTTGGATGGATCGCGGGGTGCAGAAAAAGGAAGT TGAGCGACAGACGCGAAGCCCAAAGCGTGGAATTTGGGAAGAGGCAGAAAAAAAGTGGGC GAAGAGGAAGAGAAAAAACAAGCGACGAGATGGGGAGGGACAAGAAGTTTGGGGAGGATA GAGAAAAAGAGAAACTGCCTGGAAAACAAGTTGCAAGACAATTGAAAAGTGAATGAGAAG GAAAGAGAGGAAGGTAGTAAAATCAAATAGAACTGTGGAGAGAGGGCTGGGACACGGCTT TCTCTGGTTCTGTCGTCCAGGAGATTGGAAACGCTCTCCCCTTCCGGCACCAGGCGTGCG GGATGTCGGGTGCCCCTCCCGGGAGGCCGAGGACTCCGGGCCGGAGCCTGACTGTGTGTT CCTGTTTGCCGGTGTGTGAGTGTCGGGGTGGGAATGCTCCCGGGGCCTGGAAGGGGAGGC TGCGGGCGGGGCGGGCAGATTGCGCCGCTCTGCGCCGGAGCGCAGGGGAGGAGTTGGGTA ACTGGGGCCTGCGCTGCAGGGGAGGGCGGCGGCCAGGAGTTTCGCTGTTTTGAGTCGGTG TTGGGGGGCAGCAGCAGGTTATTGTCTCTGTGGAGTTTATTTCCCCCGCCCCGCCCTCGC CTTCTACCCCAGAGTTACTTCCGTGCTGCGCCCTGACTCGGAGACACCCTCTTCCCACAC CTCTGGGTTCTTCTCCTACCTGCCTTGTCCCGCCCGGGCGTCCCCTGCAGCCACACCCTC CAGGGTTCTGCAGCCTCTGGCGCCCTGACCTCAGGATGCCCCGCTCGGCTTCCCAGCAGC ACCGCCCCTCATACCCTCGGGACACCCGTAGAATTGCTCACCACCCGCCTTCCTGCGCTC CCAGGCCGGGTTCTCAGTGCTCGGGCTCCCTGCACTGGCCCTGATCAAGTTCTCTCCCTG CAGCCTACATCTGACCTCAGAATACCAGCCGCTCCGGCCTTTCTTGTGCTTTTGATTTAA TTTGGGGAAACTCATTTTTTCCCAGCTCTGGTAAGTTAAGTAAAGGGGAAAGAAAAATCA CCGGAGGAAGACAGTCTGTTGCGTTCTATGCTGGATATGGGGTGCTCTCCACCTTCCCTA CCCTAAAAGAAAAAGGGGAATGTTCACAGCTGTACCTTAGGTGTTTGAGGGAGGCCTGTG CCAGCCATATAGGGTGGGAACTACCACTTTCAATTCCCATAGGTTTAAAGGGTGTGCTCC GCTATATGCAGAATCAATATTTTCAACATACAGGCCAGGCAGGTTGGCTCACGCCTGTAA TTCCAGCACTTTGGGAGGCCAAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAG CATGGCCAACATGGTGAAACCCCATCTCTACTAAAAATACAAAAATTAGCTGAGCGTGGT GGTGCACACCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCTG GGAGGCGGAGGTTACAGTCAGCCAAGAAGAGCTGAGATCACACCACTGCACTCCAGCCTG GGCGACAGAGCGAGACTCCATCTCAATAATAATTTAAAACATATATGTGTATATACACAT ACATATATCCAGCATACTTGTTTTGAGTCTCTACTGCGAACCAGCAATACTTTTCTCAGA AGTCATCCTTTAAAAAAATAACAAACAGAAACAAAAACCCAAGACTAAGTTTTCCCATAT GTAAAATGGGGGCAAAAAATGGGGGCCCACCAGCCAGACTTAGTGCATAGGCACGTTATT AAGGGGGTTAAATGAATTCATACACGGAAAGCTCTAGAACAGTGGATATACATGTGAGCC ATCATGATTATTATTGTGCATTTACTATCATTCTTTCCCAAGGTAGTCAACATTTTACCA TTATTATTGCTGGCCATTCCACACCACTCCTACCTGCCCTCCCGGGAAGTCAGTGCCAGA AGGGTCAGGAGAGAATAATGGTTAAGAGACTCTTAAGTGTCCAGCCATTTGCTGACAGCG TGACCTTGAGAAAGAACCATTACCTCTGCACCTTTATCTGTAAACTGGAGCTGTATCCTT CCAGGGTTATTGGGAGAATGATAAGAGAACATTCATTTAAAGTGTCCAGTGCAGGCCGGG CCAGTGGTTCAGTCCTGTAATCCCAGTTCTTTGGGAGGCCAAGGTGGGCGGATCACTTGA GCCCAGGAGTTCAAGACCAGCCTGGGCAACATGGTGAAACCTTGTCTGTACCAAAAAAAA AAAAAAAAAATTAGCTGGGCATGGTGGTGTGCACCTGTAGTCTCAGGTACTCAGGAGGCT GAGGTGGGAGGATCACTTGAGTCCCAGAGGCAGAGGTTGCAGTAAGCTGAGATCGCACTA TTGCACTCCAGCCTAGGCGACAAAGTGAGACTCTTGTCTCAAAAAAGTCCAGTGCAGTGT CTGTCTCTTAACTTCACTCAACAGAGGATGTCATGAAATGGTCAGTGTCATTCCTTTTAA TTCAAAGGGGAAGCCGAGGCAGAGAGCATCCACCTAAGTGATCCCCAGTGGAACTGCAGC TTCTGTCTTTGAGGGCACACAGCGCCCCCCACCCCATGACTTGCGGGGGAAGAGGAGATA GGGGCAGTAAGCAGACCGGGTTGGTGCACAGTGAATTCCTGTACAAGTGAAATTCCCTTT CTTCCAGAGCCCCAGGGGAGGCTCCTCTGAGGCTGGGGAGGCCTGGAGGAGGATGGGTAT GATTTAACCAGTCAATACTCAAAGATACAGGAGAGAGGGAACAAAAGACGCTTTATGGTG AGTGCTGGCTGGCGGAGGCGTGGGAGGGAGGGAGGGAGAAGCGTGCCTGGGGAGGGGGCA GGGAGGGAGAGAGAATGGAGCCGAGGAATCTGCCTGGGAGTCGGGGCCAGGGCTGGGTAG AATCCTGCCTTGGGAGCAGGGGAAGGGGAGAGAGGGGGACTCCGCAGGCCCATAAGGCGA CGTGGTCAGTGGCAAGGAAGATAATGGGCCAGCGGGAGCCTGCTTTAATGAATTAATGAC AGCCTGGCCCACCAGCCAGACATGCTAACTGGTTCTTGGCAGGTACTTTGGGGATTAAGT GGTTAAACCTGGAGGCGCATCCCGCAGGCCTCCCTCCCAGCTCGCAGCACCCCTGCCAGA ATTACTTTTAGAGCTTGAAAGCTTGGCCTTCTGTTTGGCGAGGGAGCCCGAGGAGGACAG CTGTTGGGGAGGAACCCCCCGGGAAGGGGCCAGATGTGCAGAACCAGGCAGCCTTCCTGC CACATGGTCTCTGTCTGGAGTCATCCGCTCGCATAGTGAGAGGCCAGAGTACAAGTGACT GAGCTGTGGATGGAAAAGAGCCACACCCGGGGATAATTAAATATACCCCCAGATGTGGGC TGGCTGGATTTGGCAATCATAACTCTAGAGTTTTTGAAAAGTCAGCCTTTTAGACAGGCA GATAACGAGAGGTGGGGAGGGGGCTTCCGTTTCTTGGTAGTCCTCACTAGTGTCCCTGTG ATAGGATTTCACGGGAATAGAAAGCTAACCCACAGTGTCCCTAGTCCCTGGCAACTTGCT TGTCTCATAGTAGGTGTACAATAACTATGTGCTGTGTTAAATGAATCAGAAACTATGCAA CATCAGCCGGGTATGCTGGCTCACACCTGTAATCCCAGCATTTTGAGAGGCTGAGGCGGG TGGATCACTTGAGGTCAGGAGTTCGAGACCTGCCTGGCCAATGTGGTGAAACCCCATCTC CACTAAAAATACAAAAATTAGCCAGGCATGATGGTGTGTGCCTGTAGTCCCAGCTACTTG GGAGGCTGAGGCAGGAGAATTGCATGAACCCAGGAGGCGGAGGTTGCAGTGAGCCGAGAT CGCGCCACTGTACTCTAGCCTGGGCGACAGAATGAGTGAGACTCTGTTACAAAAAAATAA AAAATAAAAAAAGAAACTATGCAACATAGTCACTATTGTTTCCCAAATTCAGGTTCTTCC ACTTATACAACTGCTAATTATTGAGTACCTTCTGTGTATAGGGCACTGTGGATACAGGAA GGACCAAGACATAAGAGTTCCCTGCTTTCATGGAGCCCACATTTTAGTGGGAAGAGACAG ACAATAAGTAAATATTGTTCTTGTTACTACTTCTGTGTAACAAATTACTCCAAAACTACT AAGTTTTGCTTCAAACAACTAGAGCCATCCCTCTGTCTCTGGGCGGGAGTGGTTCCAGGA TCCCACTTTGGATCCCAAAATCCAAGGATGCCAAGTCCTTGATATAAAATGGTGTAGTGT TTGCATATAACCCACACACTGTAGGCTTTAAATCATCTTTAGATTACTTATAATACCCAA TACAATGTAAGTGCTATGTAACTAATTATACTGTATTGTTTTTATGTGTGTTTTTTATAC TTGTGTTATTTTTAAATTTTTTTTTCCAATAGTTTTGATCTGAGGTTGGTTGAATCCATG GATGTGGAACTCACCTATATGGAAGGCTGACATATTTGACCATGCTCACACATTCTGTGG GTTAGGAATTTGGTCAGGGCATAGTGGGGGTGACTTGTCTCTGCTCCAGGATGGCTGGGG ACTGGAGTCATGGGTGGGGAGGCAACCTTATTTACATGTCTGGCTGTTAATACTGGGAGT CAGCTGGGGCTGTCAATTGGAGCAGCTATACTCAGCCTCTTCGTGTGGCTTGGGCTTCCT CACAGCATGGCAGCCGGATTCTGACACAGTGACTGAGAGCTCCAAAAGCAAGTACCCCAG GGAACTAGGTGGAAGCTGCTTTGCTTTTTCTGTCCCAGCTTCCAAAGTCACTTGGGTCAG AAGCAAGTCACAAGCTGATACAGATTCAAGGTGGGGCGGAATTAGACTCCACCTCATGGG GGAGTGGTGAGGTTCTAGAATAGCATGTGGAATGGGAGATATTTTAGTGGCCACCTTTGG ATTATGCAATCTAACACAGAGATAATTTTAGAAACTCCTCAGGGCTTTGAAGGTAATACA CAAAGGTAACACAATAGAGAGTGCCCCAGGGACTCCTCACCTGTGGTGATGAGGGAAGGC AGGACACTTTGAAGAGGAACCAGGGGAATAGTGGACTTGAATGACAGAAAGGAGCCAGCT ATATGAAGACATGCGAGAAAGGTGTTTTGGGAAGAGAGAGAGCTAAGTCCAGTGGCCCGG AGGTAAGACTGCATAGTACGTTTCAGGAAAGAAAAACAAGCAGTGTAGCTTGGTGCCAGG GCTGGGTGCCCAGATGCAGGGATGCAGAGATGAATGAGTCCCAGCCACAGCCCTCAGGTG ACCCCAGACTCTTTCAGAGACAGGAGACCCAGGCTTTGCCCCTGCCCTCACCTCTTAGTA GAAATAAACCAGTTCACCTCCTGCCAAGGTCTGAGAGGTCCTGATCCCTGAACCAACTCA CTCATGCCCACTCCCCTCAGTGCCAGGGGAACATTGTGGACATCGATTGGGTTTCCATCA CCCTTAGAACTCTCACCATTCAACTCAGCACTGGCTCCCCTCTCCTTTCCTGCTCTAAAC TGGTGCCCCTGCTGTTGGGTGGGGGATTTCTGATTTAGCCCACATCAATAAGTTGCATCC TTTTACGACTTCTGGTTGGCCAGGCAAGGAGAAAGCTCCTTCCTTTTCCTGTGGGGAGGC AACTGGCTTATCCAAGATGGCTGCTTTCCACAGAGCTTTCCCACACTGAACCTTTGCTCC ATGGGCCAGAGACTTGGGCAGGGTGGAATTTAATTGCTCTGGGAAACTTGATATAATATT ACTTTTTTAAAAAGTAGCTGGATGTGGTGGCTCATGCCTGTAATCCCAGCACTTGGGGAG GCTGAGGTGGGAAGATTGCTTGAGCCCTGGAACTTGAGACTAACCTGGGCAATATAGTGA GACCCCATCTCTACAAAAAATAAGAAATTAGTGAGGTATGGTGGTCTGCACCTGTGTTAC CAACTACTCGGGAGGCTGAGTGAGGTAGGAGGATTGCTTGAGCCCAGGAGACTGAGGCTA TAGTGAGCTATAATCGTACCACTGTACTACAGGCTGGGCAAGAGAATGAGACCCTGTCTC AGAAAAATAAATAACTTTTTCTTGATGACAAAAAATATGACAAGTTCATTGGCAACTATT TGGAAAATGCTGAATAAAAGAAAATTGTAGTCAGGCGTGGTGGCATGTGCCTGTAATCCC AGCTACTGGGGAGGCTGAGGCAGGATGATTGCTTGAGCCAGGACTTTGTGGCTGCAGTGA GCTATGATTGTGCCACTGCACTCTGTCCTGGGTGACATAATGAGACTCTGTCTCAAAACA AAACAAAACAAAACAAAACAAAAAAATGAAAAAGAAAATTGTAGTCTTGCCTCTGGAGAA AGGAGGTTCAGCTTTGAGCAGAAGGTCTGAGTAGCAGAAGATTGCAGTCCTTTCCCATGT AAAGACCAGACAGATTCTAAGCCTTTCTACCTTTCCATTGCATTAGATTTGACCCTTTAG TGATGTGATTTTCTTTCCTTCTTTCTGCCATTTCTCTTTCCTTTCTTTCTTCCTTTCTCT TTTTCTCTCTTTCTTTCCCTCCCTCCCTCCCTGCCTGCCTCCCTCCCTCCCTCTCTTCCT TCCTTCCTTCCGTCCCTCCTTCTTCCTGTCTCTCTCTGTTTCTGTCTCTGTCTCTCTCTC TCTTTGTTTTTTTGAGACGGGGTCTTACTCTGTCACCCAGGCTGGAGTGCAGTAGCAGGA TCGTAGCTCACTGCAGCCTTAACCTCCTGGGCTCAAGCGACTCTCCCACCTCAGCCTTCT GAGTAGCTGAGACTACAGGTGCACGCCACCACACCTGGCTAATTTTTGTATTTTTTGTAG AGACAGGGTTTTGCTATGTTGCCCAGGCTGGTCTTGAACTCCTGAGCTCAAGACCTCCTG CCTTGGTTTTCCAAAGTGTTGGGATTATAGGTGTGCACCACCATTCCTGGCTGGATAGGT ACTTTAAGACTTGGAATCACTATAAATATATTATCTGTAACCTGACCTTTTCCATATATC ACAGGCATTTGTTCAACAGCTTAATATTTTTCTATGAGACACTTCTTTTTGTTTGTTTGT TTTGAGATGAAGTCTCACACTGTCGCCTGAGCTGGAGTGCAATGGCGCAATCTCTCTGCA ACCTCCACCTCCCAGGTTCAAGAGATTCTCCTGCCTTAGCCTCCCGAGTAGCTGGGATTA CAGGTGCCTGCCACCACACCTGGCTTAATTTTTGTATTTTTAGTAGAGACAGAGTTTCAC TACATTGGCCATCCTGGTCTCGAACTCCTGACCTTGTGATCCACCTGCCTTGGCCTCCCA AAGTGCTGGGATTACAGGCGTGAGCCACCATGCTTAGAAGTTGGTTGGTATTGCTTTATT TGGTTAGTCCATCATTTACATTCCCCATCCATCATTGTGAAGTCACTTGAGCCCAGGAGT TCGAAGTTGTAGTGAGCTACAATTACACCACTGTACTCCAACCTGGGCAGACAACAGAGT GAGACCCCCATCTCAAAGAAAAAAAAAAAAGAACTAATTAAAACAAATTTTTTTAATGCT CACAGGTGAGAGGATTGCTTGAAGCCAGGAGTTCAATACTAGCCAGGGCAACAAAGTGAG ACCCAATCTTTACTAAAAAAAGAAAAAAGAAAAATTAGCCAAGCATGGTGGCTTGCATCT GTAGTCCTGCTACTCGGGAGGCTGAGATGGGAGGATCGCTTGAGCCCAGGGAGGTTGAGG CTGCAGTGAGCTGTGATCACGCCACTGTACTCCAACCTGGGCGACAGAGCAAGACCCTGT CTCAAAAAAAAAAAAATAATAATAATACTTTTTTTTTTTTTTTTGGCTGGGCACGGTGGC TCACACCTATAATCCCAGCACTTTGGGAGGCCGAGGTGGGTGGATCATTTGAGGTCAGGA GTTCAAGACCAGCCTGACCAACATGGTGAAACCCATCTCTACTAAAAATAGAAACAAATT AGCCTGGTGTGGTGGCACATGCCTATAGTCCCAGCTACTTGGGAGGCTGAGGCAAGAGAA TCGCTTGAATCTGGGAGGTGGAGGTTGCAGTGAGCCGAGATCGTGCCACTGAACTTCAGC CTGGGTGACAGAGAGAAACTCCATCTAAAAAAAAATGTTTTTAATGCTCTCAAATGTAAC TTTGATATCAAAACATATTTAGCGTTCTTTTGGCTGGGTGTGGTGGCTCACACCTGTAAT CCCAGCACTTTAGGGGGCCAAGGTGGGTAGAGCTCCTGAGGTCAGGAGTTTAAGACCAGC CTGGCCAACATGGTGAAACCTCGCTTCTACTAAAACAAAACAAAACAAAACAAAACAAAA CAAAACAAAACAAAAACAAAAATTAGCTGGGCGTGGTGGCGCGTGCCTGTAATCCCAGCT ACCTGGGAGGCTGAGGCAAGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCC GAGATCATGCCATTGCACTCCAGCTTGAGCGACAGAGCGAGACTCTGTCTCAAATACAAA CAAACAAAAAACATAGTTAGCATTCTTGTATTATAAAGGCTGTCTAGAGCATAAAATCAT GTCAAGATCTGGAAACACTGCCGTTGGCTCCCATATCTCATTCATGTCATTGGCCTTTAT TTATTTATTTGAGACAGGGTCTCTCTGTTGCCCAGGCTGCGGTGCAATGGCACAATCAGG GCTCACTGCAGCCTCGACCTGGGCTCAAGTGATTCTCCTACCTTTGCCTCTCCGGTAGCT GAGACTACTGGTGTGTGCCACTAATTTTTTACTTTTTTTTAGAGATGGGGTCTCGCTATG TTGCCCAGTCTGGTCTGGAACTCCTGGGCTCAAGCAGTCTTTCTGCCTTAGCCTTCCAAA GTGCTGAGATTCCAAGTGTGAGCCACTGTGCCCAGCCCATGTCACTGGCCTTTATATGTC AGGTGTCTGTTGGCTTTTGAGCTGGCTGTGACTGGCCTCAGCTGAATCTCTGTTGCCTTG CTGTGGACTGGTCTTCATGGACCACACCTCTAGCCAGTGTGGGAGTGTGGATGACGCCTA GCGTGCCTCTCCCCACTTCAGGGAAAGGTTCCAAGTCTCAGTAATGTCACTAATCTGGAA AGCTTCTCTGCCTGACTGTACCTATCATCCTGGGGGCAGGAATCATGTTCATCTAATATT CTTGGAGCTAGCACATGGTACTTAATAAGTCCTGTAAAATGCTAACACACTGATGCTGGA GAAACTAAGACAAAATGGCTTGCCTGGGTGGAGAGGGAGGTCTTCCAGGAGTGGGGATGT GTCTGAGTTACTGGAATGGATTCAAGAAGAGGTACCATTTTCTGTTTTGTGTGTGTGTGT GTGTGTTTTAGATGGAGTCTCACTCTGTTGCCCAGGCTGGAGTGCAGCGGCACGATCTTG GCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTTCCGCCTCAGCCTCCAGAGTA GCTGGGATTACAGGTGCCCACCACCACGCCCAGCTAATTTTTGTATTTTTAGTAGAGAAG GGGTTTACCATGTTGGCCAGTTTGGTGCTCTAACTCCTGACCTCAAGTGATCCAGATATG CCTGCCTTGGCCTCCCAGAGTGCTGAGATTACAGGTGTGAGCCACCACGCGTGGCCAAGG TCCATTTTTCAAAGATAGCTCAGACTTAGAATATGTGAGACTGTTGGCAGACCAAAAAGC CTAAGGCTTGATTCAGAAAATTTAACTCTGGTAACTGTGTATCTTCCTCACCAATACTTT ATGCTGAGGCAGGGAAGCTTCATGGAAAGGGACATGAATTTTGGAGTCAGGCCGACTTTC ACATCACTTTCTCCATCTCGCATTTGCCAGTTGTGTGACCTTAGGCCGATCCCATTACCT TCTGAGCCTTGGTTTCCTCATCTGTAAAATGGGAAGAATAATAGCATCTGTGCTGGAGGA GCACTATGTATAAAGCAGCTGGCGCAGATTCAGCCCCCTCTACATGTGAGTGGCTTGGAG AATAAATTCTGTTTTATCTCTGTAGTGAGCTCCTAGCATGCTATAATCTACTCCAGTGCA GTACAAGGATGTACTGGTGTTCAGAACATGGTGAGTGACAGCCTATGATATGTGTTGTTC TTATTTGGTGTAAAATTGAGTCCATAGGCTGGGTGTGGTGGCTCACACCTGTAATCCCAG CACTTTGGGGGACCGAGGTGGGTAGAGCACTTGAGATCAGGAGTTCAAGACCAGCCTGGC CAACATGGCGAAATCTCGCCTCTATTTTAAAAAAATATGTACAAAAATTAGCCAGGCATT GTGGCACACACCTGTAGTCCCAGCTACTCGGGAGGCTGAGGTGGGAGGATCGCTTGAGCC CAGGAGGTCAAGTCTGCAGTGAGCTATGATTGTGCCACTGCACTCCAGCCCAGACAACAG GCTGTTTTTAAAAACCCTGTCTTTAAAAAAAAAAAAAAACGAAGAAGAAGTTTAGTCCAT GGGCCCATCTTTATAGTATGGCCCATCTTTATGGTAAGCCTTTTGCTTAAGGCAGTTGCT AATCTGCTTTAATCCTGCCTTCCCCAATCTGGGACTCACCAAGGGCCTACTTAGGCCACT CTGACAGGGCTGGGAGAACCACTAGATCAGGGCTTCCCAGCCCGGGCAACACTGGCCTTC AGGTCCCAGAAAGATGCAAACCGCCATGCCTATTTTGCCCATTACTGTATCCCAGCACCT GGCCATGGTGACATTCACTAACTGGTGAATGAATGAATGAATGTAGGGGAGGCCTCAGGA AATTTGTGAACACCCAGTAATCAAGCTAATAACATGGCTGATTTCATCCTCCTCTTCTAC TTTCCCCTACTTGGGACAGAAAACATAGTTTGGATCCAATTCTCAAAAGATCTGTGAGCC AAAAGGGTCTGTGTTCTGGAAACATAGCCAGAGCCAGACACGACATTAGAGACATCTAAC CCATCTCCGTCATTGTACAGATGGAGAACCTGGGGCCCAGAGATAGCTGCTGAGGGTTAA GATGAGGCGAGCTTAAATGCCAGGGGATAGTAGGAGTGTCTGAGTATCTCAGGCAGGGTG AAAATGGGTGGTCTTCTAGCTGAATTTGGCTTGCAGTTGAGTTCTGTTTGACCTGCGTGG TTTTCTCCCAACACTTAAAAGTCAGGCATTTTAGCCAGGCGTGGTGGCATGTTCCTGTAG TGCCCATTACTCAGGAAGCTGGGGCAGGAGGATCACTTGAGCCCAGCAGTTCGAGACCAG CCTGGGCAACAAAGTGAGATCCCATAAAAAAAAAAAAATCAGTCATTTTCAGGTAGAAGC CTGTATTTCCAATTTTTCTTGAAAAATGAAAAGATCTAACAATGTATTCTAACACATGTA TTCCCATGTGGCAGAAACAGGCTGGAGATGAATGTCAGAAACCCCTTTAGAAAGCACAAA AACACTACAGTGTCCCCAGCCCCTCCTGGGTACCTTTAGTGGGTCCAGTGCATTTCAGTT CATGACCCCTGATTTCAGGGAGCCCCCTATGCTCTTCCCTTGATGCATAGACACCCACAC ACGCATCCTATTTTAAATACATGAGCTCATACTGTTCATGCTGTTTTGTAACCTGCTTTT TCCTCACTAAAAATAGGTGGTTGAGATCTTCCCATGTCAACACGCAAAGGTTTTCCTCAT CCTTTTTAATGGCTGCATGATGTTCTGTTGCTTGGATGAACCAGGATTTCCTTATATGGT CACTTCCTTGGGAACATTTGCATTGTTTCCTGTTTTCTGGTAGGGTAAACAAGGTTGTTA GGCACTTTTTTTGTTGTTTTAGAAACAGGGTCTTTCTGTGTCACCCAGGCTGATGTGCAG TGGCATGATCATAGCCCACTATAACTTAAACTCCTGAGCTTATGTGATCTTCCTACCTCA GCCTCCTGAGTAGCTGGGACTATAGACATGCACCACCACAATTGGCTAATTAAAAATTTT TTGTGGCCGGGCGCAGTGGCTCAGGCCTGTAATCCCAGCACTTTGGGAGGCCAAGGCAGG TGGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATAGTGAAACCCCATCTC TACTAAAAATACAAAAAAAATAGCGGGGCATGGTGGTGCATGCCTGTAATCCCAGCTACT TGGGAGGCTGAGGCCGGAGAATAGCTTGAACCAAGGTGGCGGAGGTTGCAGTGAGCCAAG ATTACGCTATTGCACTCCAGCCTGGGCAATAATTGCGAAACTCCATCTCAAAAAAAAAAA AAAAAGTTTTTTTTTGTATATGTGTAGATGGAGTCTCATTATGTGGCCCAGGCTGGTCTG GAACTCCTGGGCTCAAGTGATCCTCCCATTTTGGCCTCCCAAAGTGCTGGGATTACAGGT GTGAGCCACTGTGCCCGGCAGGGGACATTCATATTTGGACAACTTTGCAAACAAAAAGTG AAGTTCCTGAAAGTGAAATTGTTAGGTCAAAGAATGTGCATAGTATAACATGTGGGACAT GGGACATGGGCAACATTATCTTACAGGCCACAGTTTGCCTTAAGAAGAGTCTGTATTTTT TGTTTGTTTGTTTTGGCGTTGATTCTGTGCTGAGCTGAGCTACTACCCAACTCTCACTGC TTACCCTTCTGAAAGTCAAGCGAGTTGGGCTTCCAAGGCCCACCTGCCGTAAGTTCCTAG TGGGTAGGAGCTCAGGTCTCTCTCCATAGACTTTAAGTAATCACTATCTAGTAGCTGATA GCATTGATAACTGTTCACTGATAGAAGAGAGCTGGGCCAAGGAGAGCAAATACTTCTTCC AGAGGCTGCCAAATGGCCTCTTCCTTCCTCACACATCACAACCTAGCCATCTTTTCAGCT TCCTTTCCACAGTCTCCTGTGCACTCAGCTTCCTACCTGGCCGACATGAACTATACAGAT GGAGATTTAAGGGATAACATGGACCGGAGCAATCTTCTTTTCAAGAGGATTCTGCATGGA GAGCTTCTCCTCCAAGTCTTTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTATATTGT CCAGGTTGGCCTCAAACTCCTGGGCTCAAGCAATCCTCCTGCCTCAGCCACCTGAGTAGC AGGGATTAGGGACACATGCCACCATGCCCAGTCCTTCCTTCAAGTCTTAGGGACTAGGAT GATTGGTACCATTGAAACTCCTTGGTCAAAATCAACCTGCTGAAACCAAAGACAGAAGAT GCGAGAAACTGCTTTTTTTTTTTTTTTTTTGAGATGGAATCTTGCTCTCTCTCCCAGGCT GGAGTGCAATGGTACCACCTCAGTTCACTGCAACCTCTGCCTCCCGGGTTTAAGTGATTC TCCTGTCTCAGCCTCCTGACTAGCTGGGATTACAGGTGTGCGCCACCGCACCTGGCTAAT TTTTGTATTTTTAGTAGAGATGGGGTTTTACCATGTTGGCCAGGCTGGTCTCAAACTCCT GACCTCAAGTGATCCACCTGCCTCGGCCACCCAAATTGCTGGGATTACAGGCGTGAGCCA CCACACCCAGCCTGTCATCTTTATTCGTTTGCCACTTATTTACTCTCCCTCAGTAGATAA TGAATTGAGCGCCTAGTATACGCTGGGCGTTGTGCTGGGCTCTGGGAACCTAATGGTAGG AAAAGAACAAAAAAGAGACATGGCGTATACAAATGACCAGAAAATACTCTGGGAGGCTAC ACAACCAGCCGGTAATACTGGCTGCCTCTGGGAAAGGGAGTGGGGCTTAAGGGTTGGGTT GAAGGGGCTTTCCTTTTATTTTTATATTCTTCTTTGCTGTTTGAATTTGTAACTTATCAC TTGTGCAAATAGCAAGGGCAAAAAAGGTATTTTTTAAATTTTATTTATTTATTTACTTAT TGAGACAGGGTCTGGCTCTGTTGCCCAGGATGGAGTGCAGAGGCATGATCTCAGCTCACT GCAACCTCCACTTCCCGGGTTCTAGAGATTCTCGTGCCTCAGCCTCCTGAGTAGCGAAGA TTACAGGTGTGCACCACCACACCTGGCTAATTTTTGTATGTTTAGTAGAGATGAGGTTTT GCCATGTTGCCCAGGCTGGTCTCGAACTTCTGGCCTCCTTGGCCTCCCAAAGTGCTGGAA TTACAGGCAAGAGCCACCACACCCGGCCAAGGTTTTTTTTTAATTAAAAATTGGGGCCTC TTAGGAGGGAATCCAAGAGTCCTAATTCTTTGCTGACATCAGAAAAAGGGAATAAGCCTC TTGCCCCATCTAATGCTGCACTGGGGTTTACGGTTTTCAGCTTTCACCTTCCATACCCAA AGCGGCACAACATCACTGCAGCCCACGGAGGCAGGACCTTGTGGGTTCAAGTTCTCCCTC TCTGCCCGCCTCCCCCCTCACACGGTGGATGAAAAATGGAAACAGGGACATTTTTTCAAA GGTATTTCATGAATCACTTCAGCCACGAGTTTTGGCTGTGAGTTAGCATCTGAGAAAATT CTTTACGAGCCAAGTTTAAGGGAACACATCCCAAGGGTGGGGCAGTGGCTCACAGGGGTT GATGGACTTGATGTTTTAAAAATAGTTTTAAATTGCACGATTACTACTGCTGCTTGGAAA AAAGAAAGAAAGAAACCCTATATATATAAAATATAGCCCATAGCAGCCTCAAACTCCTGG GCTTATGCAATCCTCTCTCCTCAGTCTCCTGAAGTGCTGGGATTACAGGCGTGAGCCATA GCACCTGGCCTCAATTCCTACAACTTTCTGATACAGTTCCCTGCTCATCACGCTTCCCTG TTTGTGCCATGCTTATCACTGTCCTTGGTCTTGTTTGGGCCCTTCCCCCACCTAAGCCAC GCTTCCTTTTTCCAAATATGGAAAAAATATGTGTGTGTGTTCTAGGTCCTGATCAAATCC TGGGTCCGCGCTGAAGCTTCCCTGGTAATTGTAACCCCATTCTGACTTCTAGGCTATTGG TTCACCTCCAGATATTGGTCATTTACAGTACTGGTCTCTGGCATGGCATATCCTTCCAGT AAGCCTGGAGGCAAATTTAAAGCAGGCACCTGGCCTTATCTGGTGCGGATAACCATGCTT AGCACGATGTCCACACACTCAATAGCATAATAGGTACTTAATAAGTGTTCCTGTCTCTCC TTCCATCCCACCTGTGCTTAAGGCAGCATAATTATTTTAGGCTAATGCTGCAGGGTTACA CTGACTTTCATTCTGTAGGTTTATGGCTAGACACCAACAGAGATGTTTAGGGGTTACAAA AGCTGGTTTCATAAACTAAATTTAGAATGTATTTATCAATTGAGTTGATTGATGACTAAT TCCATATTCTATGAAAATATATGGTGGCTACATAACAATGCAGAGTTCCTACTGTGTTTG TGCCCTCGTGAGATAGAAGGGGAATTGGCCTGGTGTGGTGGCGCACACCTGTAATCCTAG CACTTTGGGAGGCCAATGCGGGACGATTGCTTGAGGCCAGGAGTTTGAGACCAGCCTAGG CAACATAGAAAGACCCTGTCTCTAAAAGAAAAAATAAAAATAATAAATTAGCCAGATGTG GTGGTGCATGCCGATAGTCCCAGCTAGAGGCTGAGGTGGGAGGATCGCTTGAGCTCAGGA GGTCGAGGGTGCAGTGAGCTATGATGGCGCCACTGCACTCCTGCCTGGGTGGCAGAGCGA GACCCAGTTTCTTTAAAAAAAAAAAAAAAAGCAAAAGGTTTGAAGTCACTGATTTGGATC CTTGTGACTGTCAGCTGACATAGACTATGGGGTCCATGTGTTTATGACTCATATCTTTCA TGCAGTCAGATGTATCCATTAGGGCCCGAGTAAGAGGCAGAAAGTGTTTCCAAACTCAGT AATCAGAGGAGAATTTAGGACAGCTTCAACAGCAAAGGCGTGGGCAGGGTTTGGGAAACC AGCGAGAGTGAATGCAGTACCCAGGCTTGGCCATAGAGGGGAGCTATTCCCACCCTGGCC TGAAGGTGCCAGGGTAAGGAATGGGACCTGGAGTCTCCAGGAGGGTGTCACTGTACCAGA GTCCAGACAGCGGCTGTGGCCAACCTCTGACCAGTGGGAGGGGAGCTGGGGAACAAACAC CTGATCTTACTTTCCCATTAGTGCCTCCTGTTGGCCAAACCCAGAAGGAAGCCAGAAGTC AAGGGTACCAGCTGCTACAGTTCATGCAAGTCAACATCTCAGACTTTTTCAAACCCAGAA GCCATAAAGTGATCTCCCTTCCACTTTCTCTCCTATATCACTTGGTGTGTATTACCCACA TGCTCGTTCATATGCCACCTGCTTTAGAATAACGGGTGATACGTTCTTATCTCCCCCGCT AACTTATAGCCACCTTATCTGTCCTTTTAAGTCTGGGCACGGTGGCTCATGCCTGTAATC ACAGCACTTTGGGAGGCTGAGGTGGGTGGATCACTTGAAGATAGGAGTTCAAGACCAGTC TGGCCAACATGGCAAAACTCAGTCTCTACTAAAAATACAAAAATTTAGCCGGGCATGATG GCATGCACCTGTAGTCCCAGCTACTTGGGAGGCTGAGGCAGGAGGCAGAGGTTGCTTGAA CCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATCGTACCACTGCACTCCAGCCTGGGCAAC AGAACGAGACCTTGTCTCAAAAACAAACAAACAAACAAACAAACAAACAAACAAACAAAA AACCCTACCTTTTTAAGGTGTACAAGTCAATGATGAGGAGTATACATAGAATTTTGCAGC CATCTTCACAGTCAACTTTGGAAAATTTTCGTTTCCCTGAAAGAAACCCCATGCGCATGA GTATCACTCCCCAATTCCTCCTATCCGCCCCGGCCCTAGGCAACCACCATTCTCCTTTCT GTCCCAGAAGATCTGCCTGTTGTGGACATTTCATATAAATGGAATCACACAATATGTGTC CTTTTGTGTCTGGCTTCTTTGACTTAGCATGATGCCTTCAAGGTTCATCCATCTTCACGT ATCAATACTTCATTCCTTTTTGATGGCTGACTAATAGTCCATTGTATGGAAAGACCACAT TTTGTTTATTCATCAGTTGATGGACATTTGGGTTGTTTCCGTATTTTGCTATTATGGATA ATTCTGCCATGAGCATTTGTGCACACATTTTGTGCATTCTGTGGTGGATGCTCCTGGGTA TGGGCTGTTTTTTCTGCCCTGCCTAGGATGCCTCATTTTCTTATCCTGGTTAGTTTCCTG GCACTCTTCAATAGTCAGCAGGGGCCTGCCACTCTCTCTGAGGAGTCTGCTTTGTCTCCC TTATGAGCTGCCTCCCCTGGGCTCCTATAGACCACGTTTCCCCAGACTGCATGTGCTCTT TACATGGGACTGTCATTATCCACTTCTTCCCATCTCCCTGTTGGTTCTGAGCCCCTCAAG GGGCAAGAATTACGTCATTGAACCTGTAGCCCCTAGTATGGCACTTGGCATACTTGGGAA TAAGTGAATGGATGAATGAACGAACAAACAAACAAAAGAGAACAGAGACTGCCCTACAAC TCTCTCTTGAATCTGGGTCTATGAAATGAATCGAGGAAGGTCCTGTTCTGAATTTGGAGA AGCAAAAAGTTCATGTGTCTCTAGATTCTTCTTTTTAAAAACATCTCTGAAGATGCCTAT GTAAATATCTAGGTCTAAAAGCAGAGAGGGGAGTGTGTGTGCACGCACAAATGTCTATTT GGGGAAGGCTGCTACATAGACAGAGATTCTGGTAAGGGGAAGAGTGCCAAGACTAGCTTT TGAGGCATCCTTCCTCCAAAACCAGAGCTTTGCATCCAGTAGCTCTCCCCTCCCTCCTCC CCCTCCCGACATCCGGGGCTGAGCGTGCAGAGGCCCACTGCACTGACGTCACCCCCAGCA GCTGTCTGCACTGACCAAAATACCAATCTTTATTTCTGCAGGTTGGTGAAAACCCTGTGT CCTTGGAGAAAGCTGGTTCCCGTTTTCCAGAGGGGGAGCCCAGAGCTTGAAAGGCCGCGG TTGGCACTTCGAGAAGGAAGTGGAGAGTAAAGACAGCGCCTGGAGCGATCGTAGAAACAC AGAATGGGACTGGGGAAGCCCTTTGGAAATCCAGCTGCAGAAACAGACACCCCAATGCTA TTTACATACAGCTCTATATATATAAAAAAAGAAAATATGAATATTA OMIM ID 603447