Entrez gene ID | | 8751 |
Official gene symbol | | ADAM15 |
Full name | | ADAM metallopeptidase domain 15 |
Aliases | | ,MDC15, |
Gene summary | | The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q21.3 |
Gene position | | 155023762 - 155035252 Map Viewer |
Gene orientation | | plus |
Gene size | | 11491 bp |
Gene sequence |
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OMIM ID | | 605548 |
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