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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for FADD (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8772 Official gene symbol FADD Full name Fas (TNFRSF6)-associated via death domain Aliases ,GIG3,MGC8528,MORT1, Gene summary The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq] Location Chromosome: 11   Locus: 11q13.3 Gene position 70049269 - 70053508  Map Viewer Gene orientation plus Gene size 4240 bp Gene sequence >FADD:15355064..15359303:Length=4240 GACGATACGCCGGGCGCAGGCGCAGAAGCCGCGCCCGTCCGCGGCGCCGCCAGCCAGGGC GGAAACGGCTGCGGCTTCGCTAGGGACGCATGCGCGGGTCCCTTAGTTTTCGCGAGATAA CGGTCGAAAACGCGCTCTTGTCGATTTCCTGTAGTGAATCAGGCACCGGAGTGCAGGTTC GGGGGTGGAATCCTTGGGCCGCTGGGCAAGCGGCGAGACCTGGCCAGGGCCAGCGAGCCG AGGACAGAGGGCGCACGGAGGGCCGGGCCGCAGCCCCGGCCGCTTGCAGACCCCGCCATG GACCCGTTCCTGGTGCTGCTGCACTCGGTGTCGTCCAGCCTGTCGAGCAGCGAGCTGACC GAGCTCAAGTTCCTATGCCTCGGGCGCGTGGGCAAGCGCAAGCTGGAGCGCGTGCAGAGC GGCCTAGACCTCTTCTCCATGCTGCTGGAGCAGAACGACCTGGAGCCCGGGCACACCGAG CTCCTGCGCGAGCTGCTCGCCTCCCTGCGGCGCCACGACCTGCTGCGGCGCGTCGACGAC TTCGAGGCGGGGGCGGCGGCCGGGGCCGCGCCTGGGGAAGAAGGTGGGCGCGGGGCCGGG CCGGGGGAGCCAGGGCCTGGTCGCCCGGCTGTAGGTGCTGCGAGGCTCCTCCGGTTGGCC TCCAGGCGCCTCCCCTTTGCCGGGTTTGATTTGCGTGGGTTTTCTCCGTACAGCCCTGGT TTTGCAGATGGGAGAGCCAGAAACGCAGAAAAGTTAACTTATTCGAGGTTGCAGGGCGTG GACACGCACAGTCCTTTTTCCTCCACCCACTTCTGCCCGGGTAAATTAGAAAACTCACTG AAGAAAAGATGAGTCAGAGAAGGTGTGGGGGAGGGGCAGAGGTTGGGTGAGCCTGCCTCG CATCATTTCCTTTCTGTCTCGGAATATGCTTTTCACGGCTGTCTGAGAGTAATACTAGCA TTCAGTAACTCCTACCCAGGGGCTTACAGTGTGCCGCTTACCCTTGTAACTGCCAAATAC AATTTTCGCAGTAGCCCTGTGGCTTAGATACTGTTAGCTATCACTGTTCCCATTTTACAG AGGACAGGACTGTGGCTCACAGGTTAAGTGGCTTTGTCGAAATGCGCAGCCGATAACTGA CGGAGCTAGGCTTGAGCCAAGCAGTCCGGCCTCCGGATGGGTAGTGTTAGCCACTACACT GCCTCTCTGGTCAAGTTCATTGTGGAGTGGCTTCCTGTCCTGCTCTCGGTCACTCCCTCT CCACCCTCGCCTGTGGATTGCAGCAGCTTCCAGGATAAAAAAGAAACCCTGAGTACAGCA GAGTTTCTCAGCCCTACCCCCCTTGTTCTCAGAGTCGGGAGAGGCTTGGGAGTGCTCTGG GGACGCCTCTCAGAGGCTTCAAGCTGTAGCTTGGAATCAGCCATTCAGTCACCAATCAGA TAGGGCCTAAATGTGTCACCATGGGTTTCACTCTGTAAAGACTGGTGCCTGTTGGGGACA GGATGGACAGAACAGCTCTCTGCCTGAGAGCAGTCAAGTCCAGATTTTAAAAAAAATCAG TACTGAACAAACAAAACAGGACGTAGAAAAATCGGGTTTTATGGATATTTAATGTCTGGA AAAACACTGATAAATTGCATTTTAAAGGCGGTCTACGAAACATAGCTGACATTTGAGATG TATGTGTGCTTGGTTTTATTTATATCGTCATGTAGTTACTGTGTGCTGGGAAAAGTACAC CAGAAGGTGAGCGGTGGGTATGGACAGGTTGGTAGCGGGCGACTCTGCCTTCCTCCCCAG AAGTTCAGCATAGCGGTTAAGGGTCGACTCTGGCACCACACTCTTAGGGTTTCAGAACAT GGCTCTGCCATCGTCTAGCTACACGATCTCAGGAATGTCCATTAGCTTCCCTGTGCCTCA ATTTCCTCATCTGTACAGTCATGGTAACACAGTGCCCAGCCCACAGGGCTGTCAGAGCTG CGGGAGCTGGTACACCTGCCAACGGTGTCTCAGAATTGCCAGTAGTCCAAGCAGCACCCT GTCCTGCCTCTCCTTTCCTCTCTTCACATTCCAGAAGCGGCCTTTTATGGTCTTGTGACC AGCTCCCTGATCTCAGTGGTGACGTCAGCAGATGAGGAGTATGGTAGCCAGGGACTGAAG ACTGGTGGTCACTCGGGGCAGCTTTCTAAATAACAATTGGAGTGCCTACTAGTTTCCTGT GATTGCCATAACAAATGATCACAAATCTGGTGGCCTGAAGCAATAGAAATCTACCCCCTC AATCTGGAGGCCAGAAATCTGAATAAGCAGGGTGCCACAGACCGGCACACCCTCGGAATG CTGTTGGGGAGGCTCCTTCCGGGTCTCGTCCGCTTTGTGGTGGCTCCAGGCATTCTTTGA CTTGTGGCCGCTTCACTCCAGGCTCACACGGCCTTCCCTGTGTGTCTCCTGCAAGGATAC CTATCATTGGTGCATCCAGGTCATCCAGGATGATCTCCTCTCAAGACCCTCAGCTTACCT TTGCAAAGATGCTTTTTCCAAAGAACATTCATGGTTTCAGCAATTTCACGTGAACATACC TTGGGGTGACATCGTTCAGCCTGCTGTAGGGCAGGATGTGGGATCAACCCTATTTTCTTC CCTCCCACAACTCCCCAGCCCCTCCCTCAGTGTCTCCTGCTCTAAGTAGGTAGCTCCACT ACAACTTCCTTTGGCACTTGAGTCTTCAGTGGGCCACGCCTCCTAGGACAGTATTAGAGA GCAGGGGGTTTGGCTGAGGTGGAATCAGGCCACTCTTGGGCATTTGGTGCAGCCCCTTTG CTGCCAGGCGACTCTAGCCTCTACAGAGGACCTCGTGTAGGCACCTCTGTCCACTCAGCA CTTGGCGTCTGTGCTGAAAAGCCCTAGGGAGGATTGTGGGGTCGCTTGTCTCCAAACCTA TGGTAAACCGTTCTGTTCTTTCCTTCCCAGACCTGTGTGCAGCATTTAACGTCATATGTG ATAATGTGGGGAAAGATTGGAGAAGGCTGGCTCGTCAGCTCAAAGTCTCAGACACCAAGA TCGACAGCATCGAGGACAGATACCCCCGCAACCTGACAGAGCGTGTGCGGGAGTCACTGA GAATCTGGAAGAACACAGAGAAGGAGAACGCAACAGTGGCCCACCTGGTGGGGGCTCTCA GGTCCTGCCAGATGAACCTGGTGGCTGACCTGGTACAAGAGGTTCAGCAGGCCCGTGACC TCCAGAACAGGAGTGGGGCCATGTCCCCGATGTCATGGAACTCAGACGCATCTACCTCCG AAGCGTCCTGATGGGCCGCTGCTTTGCGCTGGTGGACCACAGGCATCTACACAGCCTGGA CTTTGGTTCTCTCCAGGAAGGTAGCCCAGCACTGTGAAGACCCAGCAGGAAGCCAGGCTG AGTGAGCCACAGACCACCTGCTTCTGAACTCAAGCTGCGTTTATTAATGCCTCTCCCGCA CCAGGCCGGGCTTGGGCCCTGCACAGATATTTCCATTTCTTCCTCACTATGACACTGAGC AAGATCTTGTCTCCACTAAATGAGCTCCTGCGGGAGTAGTTGGAAAGTTGGAACCGTGTC CAGCACAGAAGGAATCTGTGCAGATGAGCAGTCACACTGTTACTCCACAGCGGAGGAGAC CAGCTCAGAGGCCCAGGAATCGGAGCGAAGCAGAGAGGTGGAGAACTGGGATTTGAACCC CCGCCATCCTTCACCAGAGCCCATGCTCAACCACTGTGGCGTTCTGCTGCCCCTGCAGTT GGCAGAAAGGATGTTTTGTCCCATTTCCTTGGAGGCCACCGGGACAGACCTGGACACTAG GGTCAGGCGGGGTGCTGTGGTGGGGAGAGGCATGGCTGGGGTGGGGGTGGGGAGACCTGG TTGGCCGTGGTCCAGCTCTTGGCCCCTGTGTGAGTTGAGTCTCCTCTCTGAGACTGCTAA GTAGGGGCAGTGATGGTTGCCAGGACGAATTGAGATAATATCTGTGAGGTGCTGATGAGT GATTGACACACAGCACTCTCTAAATCTTCCTTGTGAGGATTATGGGTCCTGCAATTCTAC AGTTTCTTACTGTTTTGTATCAAAATCACTATCTTTCTGATAACAGAATTGCCAAGGCAG CGGGATCTCGTATCTTTAAAAAGCAGTCCTCTTATTCCTAAGGTAATCCTATTAAAACAC AGCTTTACAACTTCCATACTACAAAAAATTTTCTATTCCT OMIM ID 602457