Entrez gene ID | | 8840 |
Official gene symbol | | WISP1 |
Full name | | WNT1 inducible signaling pathway protein 1 |
Aliases | | ,CCN4,WISP1c,WISP1i,WISP1tc, |
Gene summary | | This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8q24.1-q24.3 |
Gene position | | 134203312 - 134241571 Map Viewer |
Gene orientation | | plus |
Gene size | | 38260 bp |
Gene sequence |
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OMIM ID | | 603398 |
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