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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for NR1I2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID8856
Official gene symbolNR1I2
Full namenuclear receptor subfamily 1, group I, member 2
Aliases,BXR,ONR1,PAR,PAR1,PAR2,PARq,PRR,PXR,SAR,SXR,
Gene summaryThis gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq]
LocationChromosome: 3   Locus: 3q12-q13.3
Gene position119499331 - 119537332  Map Viewer
Gene orientationplus
Gene size38002 bp
Gene sequence
OMIM ID603065