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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for APLN (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8862 Official gene symbol APLN Full name apelin Aliases ,APEL,XNPEP2, Gene summary This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1. Location Chromosome: X   Locus: Xq25-q26.3 Gene position 128788933 - 128779236  Map Viewer Gene orientation minus Gene size 9698 bp Gene sequence >APLN:complement(13046946..13056643):Length=9698 GAGCATTCTCTCTGGCAGCCGGGGTCACGGGCAGTTGCAGCCGCGGCCGAGCAGCCAGCC GCTAAGAAAGAGCTCGCCGCTGCCGCTCCCGGAGCCGCCGAGGCCAGCTTCGCGGCGCTG CCCCGCGGCGGGAGAGGAGGCTGCAGAAGAGCGGAGGCGGCCAGCGGGAGCGGCGGGGCT CAGCGCGCACACTCAGCGGCCGGGGAGCCTCCCGAGCTCTGCGCCCGCACGCGCCAGCCG CGGCTCGCGCCTTTCTTGGCCTCCGGGCGCCCGACCTCTCCTCCCCCGCGCCGGCTCGCC GGGGCCGCGGCGGCCCAAGGAGCAGCATGAATCTGCGGCTCTGCGTGCAGGCGCTCCTGC TGCTCTGGCTCTCCTTGACCGCGGTGTGTGGAGGTGAGTGCGCGCCCTCCCGCTCGCCCG GGCTGCAGCCGGCGTGCTCCTTTCCCTCCGCCCTATTCGCACTCTCCCCGCCTCCCGGGG AGCCCGGCGCGAGCCGTGCAGTAGCAGCCACGCGCCGGCCAGCGCCAGGCAGCAGATTGA CAGAGCGCCCCGAGCCATGGGGCGGCTGGCCACAAGGACTGCTTCTTTTGCGGGGCTCAA CTCGGCCTTTGGCATCACCTGCCCGTCACCTTGTCCCTCCTAACCGTCGCTCGCAGTCCC AGGAGCTCAGGACCACAGGTGTGCGCCGCGTGTCCCACGCCCTGCACCCCGCGTGGTAGA GGTGGAGGCGGGGGACATGCCCGCTCCCTCGTGGATCGATGGAAGGAACTGACCAGAGTC GAGTGGGCTGGGCTCCCATGTTGAACGTCTTCTGGTCCCTGAAGGCTGGGAGCCTCCCGC CAGTCCAGGGGCGCGGGAAACCGGGGATGATGTGCCAACATGCAGACGTGACACTTGTTG CATAGGCAGGAGTGCGCGGAGGGGGTGGCGGCATGGAGCCCAGCTGTTGCTCCTTTCGGC CTGCATGTGTGAGCAGAGGCAGCCTCCCCCAGGCAGGGCCGGGCCCAGCCGGGCTGGGCT GGTCTTCTCCTCCCTAACCCCAAGGTCCTGGCTGGTCTCCTCCCCTGCACAGGATGCCCT CCCCATAGCCTCCATCCCACCCCCAGAGACTTGGTTCTCTTACATCCTGGCTCCAGCCTT CCTTTCTGTCCCAGGCACGGACATGCTTCACTTTAGTCTCCCTGCCGCTAGGCACCAAAG GAGGAAGCACAGCACCTGACCCGACCCCTCCCTGCAGCTCAGGAAAGGGGAGTCCTTTTG CCCTCACCTGCCAATACTTGGCACTAGTGCCCATGTCCGCCCCTAGCCTGGTCCCCAACC ACGCCCCAGCAGCCCCATCCCAGGCTGCCTGTCCTCTGTGTCAATGTCTCCTGGGGCTGC CAGCTCCCACCTCCAGCTGCCACAGTCCTATGATCTGGCTGTCATTGCTGCCTGCCTGGC ACCACACAAGGGGAAGGCCAAGACCAGGTGGACTAACGCCAGGACCATGGCTGGAGTCAC AGGGAGGTGGGAGCAGAAAGAAGGAGAAGGCAGGGCAGTGAGTTTCCTGGGGCAAGGGCA CAGGGCCCTAAGTGGTTCCAAACCCTCCAGAACAGGAGGATGGCATGCAGCCCAGGAGCC TCCGAGGGGCCCAGCCAGCTCTGCCTGCCTCTCATCGCAGGCCACCTCCTTTCTCTGCTC TTGCTTTTTGGCCCTGCTGTGGCTCTGGGAACACTGCCTGGCTTCTCAGAAAGGTGCAGT GGTTGGGGCTGGCACCTCCTGCCTCCAGGTAGCTGGCCGGTGATTTCTCTATTCAAGACC TGAACACGAAGTGAGCCACCACCACAGTAAGAAGTGGGTAGGCTTTTTCCACAGAAACTC CTGTCAGGCAGGTAACAGAGGGAGCAAAAGATACGAATGTAAGATACGAATGATACACCA TACCAGCCTATCCTCAGGGAGCCTACCATCTGGTGTCATTGGCAAGGCATGACACTTGCA CAATACCACCACAGGCAAATAGTCCAGGGTGGTGCCTTCAGGGAAGAAGAAGACTGGGTG CAGAGAGTGTTCCAGAGGAAGGTAGGGCTCCTGGATCTGCACACTTGGTGCTCCCCCCAG AGGCTGTGGGGAGACCCCTGGCCAATAGACAACCACTCAGACCCTCCTGGGTCCCAGCCA TTGGGACAGTACTAGCAAAGGGGAGAGAGCTGGTTTCAAGGGAAGGGAAGTCAGCCAGGA TGCCCGAACACCATGTGGCTGGTCCAGAGCCTGCCACTTCGTGCTTTAATTCCCCCGTCT TCATTAGGTCATCTGTCCACTGTGATTTGGATAAATTCGTTGCCCTCACATTTTGCTCAA GCCTCGTGCTGGAAACTTTCAGGGCTCTCACTGACTTCTCTACTCCCTGACTTCTCCTGG AGCCAAGGAAGGGCATGTCCCTGGAAGTGGCCACCAGCCAAGGGTCCAGGTACACATGTC CTGCTCCCGCTGGCTCCTGTCCTGGGTTAGAAGCAGGAATCCCAGAACCACTTTGTCCTT GGCCCGGACTGGCATGCTGTCCCCAGCCAGAGTCCCCAGTCAAAGTTCCAGCCTGAAAAC CACACTTCCTCCTCTCCACAGTCTGTCCTGACTTGAAATGTCCACCCCCGACCCCTCTCC ACGCTGCCTCTCATCACCCCGCTACCACCACGTACACTCCTCCACTGCCTCCTGACCTGG GATACACTTTGCTCTTGTGAGTCTGAGAACTCCTGGTCCAGGGCCAAGTGTCCCTCGGTC TCTGAGCACCCCTCTTTTTCCCCTTCTCCTCCCCCTCCGCAGGCCCAGCTCAAAGCCTGC AGTCACAGTGGGAGTGTGAGGAGAGCCTACTGTACCCCTCCTGCTCAGGGAAGGGCATCT CTACTCCATCCCCAGTCCTCAGCACTAAGCACCCGTGTAACCTGAGCCAGGCCTCTCCTC GCAAAGAACTAAGGCAAGGGAAGCAGAGGGCCACCAGACAGAGCATGATGTATCCCAGGG CAGCAAAGCTGGCACTGGAGACAGCACAGGGCCCTGGAGAAGGCGACTGGGATGGGGGGC TGGGCAGACAAAGAGACACATGCAGGACCACAGAGCAGTGGAGGGGCATTGCCAGCAGGG TCCCCACCGGAGCATACGTTTGGGCTTTTAAAGTCATCACAAGACAGGCCAGACTGAGAG AGGAAAAACAGGTGCGTCATTCCTGATGAGACTGGCATGTTCCTGAAAAGTCGCAAGTAC CTCTTTGTGCATTGGCAGGGTTGGAGTTCAGATAGCATGAAAGTCAAATCCTGTCCTCCC CCTGACTGTGGTTCTCAGCGTGGAGATGTTGTAGCTTCGTGGCTGATGGCACTTCAGCAG GCAATGGCTCCAATCTCTCTAGGCTCGAGATTGTTTGGAGGATTGCTCCAGCCTCCTTTT ACGTAGCAAATGAGCTGGAAGAAAATATTTAAGTGCATTAGGGCTGGCCTCCATTTCTAA AGGGGAATTCTTTTTTACAGTCAAGACTTCTGCAGTGATGAGAATCAACAGCCTCTAATT TGTTCCTTTGGACAGCATAAAGCCAGGGTTTCAGATGTCAGCTTATCTGATGGTGAGCCA GACTCAGAATCAAAAGTAGGAAACAGGTGGGTGACGGGCTCAGAGTGCGGGAGGAGCCAG CAGATCTCGGTGATGCTGAGGACAATGAGTCCCCAACGCAATGGGAGGGATGCAAGAAGC CTGGGGCTGCTCTCCAGGGCCCGGCTGGGGGTTCAGTCAGCTCAGAGTGGTTCTTCTCTG CAGACCTAGAGTCTAGACATCTTCCTGGCCAGAGCCACCAACCCTGCTCCCCATCCTGAC ATATGGCCTCTAGCCCTCCCTTTCTGACTGCCAGACACTCACAATCTGAGCACCTGGAGA TGATGCCCTCCCCCTCCTGGCACCATGCTTCTCTTCTCCATGTCTGCCACCACCCTGAGC TACAATGGCCTGCACCACTGCCCCATCCCTTCTGCACCCCCAGCAGTCGAAGGTGCAGAG GTGAGAGCCAAGTGTTGACTTGGTTCACTTCACAAGGCCCCTAGGTCCTTCCCCTGCTCC TTATCAGCATCATTCAGATCCGCCCTCAGTGATCAGGGTGAGCCTTGTGGGGACCCCAGA ACTCAAGGCAGAGGCTGAAGCAGCTGCAGTGGGGAGCTTAGTGAAGGTCTTTCCTTCCTT TCCCTCTCCAGCCCCAGCCCCCTCACAGATGGCGCCAAGAGGGTAGCTCTATGACAGTCA GACAGAAGCAGCCCCCTTGTTCCATCCATACTTACTGCTCCAAAGTGCTAAGATAATTCT TCTTTTAATTCTCATAGGTTATGAATTTAAGGGATAAGTTGGCACGGAAGTGTGGCTAGT TAACCAAATGACCCAAGTCAACAGCGGGGTCCTCATGGGCCTGGCAATTTTTCTTGGGGA AAGAGGGAAGGAGGGTGCAGGCTTGGAGAATATGTGTTTATGTGTGTGTGTGTGGAGGGG GTGGGTATGTCTGGGTGTGAGTGGGGAGAACTGCAGGCTCAGAAGCCTGGGGGAAGAGGG CCCTAAGGCCAAACCCACCCACTTTTGGCCCAAGAGGAGGCTGAACACTTGGAAATTGTG TGCAAGCAGAGGAGGACTCACAAAAACCAAGGAGCCAAGGAAGGAACAGAGCGTGGGGAT GTTGGAGGCAGAGGCAGAGGGGAAGGGGGAGCTGCCAGGGGTATGATTGGGGTGTGAGCA GCCAATGGGAGGCTCTATGGAAACTGTGAGCAAGTGGTGGGAATTCCTGGGTAGATGGCA ATGGGGCTCGAGGGACAGGGATCTAGATGCAGGCAAATCAGATGGTGTGCAGGGGGAGAG AGACTGTTATTCATTATCTCTGGCCTCAGATGCTGTATCTGCACAGGCCTGTACTGGACA TTGCACAAGTACCCTGCCTGGCTGCCTCTTCCCCAGCACCATCTCATCTCCACACACTGC CTGCCACCACCAGCCAGGCTTGTCTTGGGGGTGGCAGCTCAGCTTCCCTGCATGGACTGC AGGCTTCACGAGAGTCGGCCTGCATGCCTTTTCCCTCACTGCACCCAAGGATACCCTGCA CCACTTGGATTCCATTGTCAGGGCTCAGTCTGGTGTCAGGAGGCCTCTACTCTAAGCCTC CTGACAGATGTGGACAGATGTAAAGAGGAGCCCCAGAGTGCAGAATAGAAGCCAGCTGGG ATTGAAATGGAAGGAATTTACATGAGACACAGGATGCAGGGTGTGATCTGGGAATTTCAG GAGGTAGGGCATTGGTGGGGAGGTACCAACTGCAACAGCCCACCCCCCTCCTGGTGCACA GACATGCTGCTGAAGGTGACCATTGTTTCATTTATTCATTCTCAAATATTCATGCAATAT TTATTGGTCTCTAAATCTGGTCTCAGGTCTCTAAATCTGGTCACAGCATGAGGCAGGCTG AGTCAGAGACCTCTCCCCCTTAACCCGCCTGGCCCAGCCCCATCCACTGGGAGGACTTGG CGCCCTAGAGATGCCTAACCACCGATGAGACACCCAGGGGCGAGATATGAGCTCCCTAGT ACTCACAAGTGGGTCATCCTGCATATCAAAGGATGTAGGAGTACAATGACGTGATGTTCG GGATTTGCTTTAAAATACTGCAGTCAAGGAAAATAGAAAAGGGATAACTAAAGCATATGT GACTCCATCTGGATAACTGTTGAATCTGGGTGATGGGTCCATGGCGGTGGGAGGGTCATT GTAATGTCATATGTCTGAAATGTTTGAAGTGTACCAGTTGCAGGGGTGCCGTGGTGATTA CTGCCTCCTGCCCCCCAGCCAAGTACAGGCGTGACAACCCAAAGTGCACACCCCCCAATG ACGTTCCAAAGAAAGAACCCACTTGTGCCTGTCAGAAACATGATATAACTGTCAAAAGGA CAGAAAGTCAGCTACATCAATGGCAAGATGTGAGTAGTAGGTTCCGTTTGTCCCAGGACA GTGCAGAAATGGCAAATTTTCCCTCAATATGAAAAAAAGAAACAAAGAAAATCTATGAGA AGTGCCACCACATGGACAGACCACCCCTCCCGCGGGCCTGTGGTCTGCAGCCCCTGCCCG TTTCCAACAACCTTCCTCACTAACAGGCTTTCTCCTTCCTGCAGGGTCCCTGATGCCGCT TCCCGATGGGAATGGGCTGGAAGACGGCAATGTCCGCCACCTGGTGCAGCCCAGAGGGTC AAGGAATGGGCCAGGGCCCTGGCAGGGAGGTCGGAGGAAATTCCGCCGCCAGCGGCCCCG CCTCTCCCATAAGGGACCCATGCCTTTCTGAAGCAGGTACTTGAGCCTCTGTTCAGTGGA CAGTGCTAAAGCGGAGGGAGAAGGACAGCCTAGAAGCCGGGTGATCCTGCCGCTCATCAC TGGCCAGACACATCCATCAAACAGTCCTGGCGCCACACTCACAGAGGCTTAGAGCTGGCA AGAGAGCTTATGGGGCAGCTGTCTAGCCCCTTTATTTTACAGACGATCTCCTCGTCTGAG GCCTAGAGAGGGGCTTGATACTTGGGGCCAGTCTCCCTTCCACCCTGCTGCCTGGGGTTG GGGAGGCTGGCCTGCTTAGAGATTTCTAGACATCCTGGTGGACCTTAATGGCTGGGGAGG GGTGCCCAGGGCAAACCTACAGATGTCCAGTGTAGATTGTCGCCAGAGTTGGGGAAGGAG GCAGAGAGCTCTAGGGGCTCTCAGGCAGAGAACAAGAGGACAGTTGTGGCTGTGGTTGCC CGGAGCTGTGAGAAGGAGGGAAGAACCAAGGTGGCAGCAGAGAGAGGAGAGCTGAAGCCT GCCCCTTCCCTGGTCTGCTGGCTGTCCCACTGCAGTGGGGACAGGCAGGCACCAACTCAG GGGCCTTGGGATTGAGGTTTGGGCTGAGTGGAGTTTGGGGGAAAGAGAAGGCGGTCTCCT CTCTCCTCTCCTTTCCTGGGGAGTTCCTTTGGCCTAGGATATGTCCATGACTTCTCTCTT GTCATTTTTGTCTCCTTAGGACTGAAGGGGCCCCCAAGTGCCCACCCCCGGCGGTTATGT CTCCTCCATAGATTGGTCTGCTTCTCTGGAGGCCTCACGTCCATTCAGCTCTCACCTCGC ACCTGCTGTAGCCACCAGTGGGCCCAGCTCTTCTCACCTGCCTGCTTCCCCCAGTGGCGT GCTCCTGGCTGTAGTTTGGATGATTCCCGTTCTCTCACAAGAATCCGTCCAGTCCATCTT CCTGGCCCCTCCCTGGACTGACTTTGGAGACCTAGCCCCAGAAAGCCTCCCTTCTTCTCC AGGTCCCCTCCGCCCTAGTCCCTGCCTGTCTCATCTAACGCCCCAAACCTTCATTTGGGC CTTCCTTCCTCATGTCTGCCCTGAGCGCGGGGTGGAAGTGCTCCCTTCTGTGGGCTCCAG CAGATCCCTTGTTTTCCTGTCAGTTGGACCCCTCACCTGGCCTCCAGGGAAGAATGCAGA GAAAAGCAAGGAGAGACTCTAGTTAAGAGGTGCTGGCTGCGGGGATCCAGACAGGGCACA TTGGGGGCATGGAAGTGCCAGGGTGGTTTTCAGGAGCTCTGGTGAAGTGGGTGGAGCATC AGCGTTTGCTCAGTTAAGGGAGAGGTAGAGAGGGGCCCGTGAAGTCCTTTGTCACTTCTC TTGCCTTAGTGTGCCTCCCAATACTCCCTTCTTCCTGCCCCCACACCCCATCCCCAGCTA GCCCAAGCTCCAGGTCAGGAGGGGAGGGTGCTGGGCCTGACATGGCTATATACCCTCCCA GGAGTAAAAGCCAAGCAAGAGGTTGTTTTTGCCAAGAATCACAGAATGTTAGAGCTGACA GGACCCTTGAAGGTCACTTAGCCTTCTTAGGCAAACGCCTGCAAAACAGAAGCCTGGAGA GGGGAGTGACCTGCTCAGAGTCATTGCAGAGCCGGGATGGGGACCAGGTCTCCCATCTCC TACTTTATGACGCCCTCTTCCCTCTTGATGATGTCTTTTCAAAGCAAATGAAGTGCCTTT TCCCGAGGCTGGGGCTGGGGGTGGCTGGGAGGGGAAGGGAAGGGAGAGGCAAGCTGGCTG TGAACTGTCCTGTTGTGGGGCTGGAGCTGCTCCCACCTCCCTGACCTACCCCTGCTGCAC CATTCCCCCAGCTGGGCTGGAAGGTTCCATAACTGGCCAGCTGCCCCCATAACTGGCAGC ATTCCCAGACCCAGGGTACTCTAATAGGGGCGGCTCAGGCACTGAGACTACCGCTCAACC CCAGGGTGGTTTTCAGGAGTCCGAGGTAGCCTTCAATCACTGGACTCCATGGCCTTCCCT TCGTGTTGACCGGACCTTCCTTCCAGGGCTTTTCCTTTGGGGGAGGCGGAGAGGGGAGAA GAAGGAAGGGAAGGGCAGAAGGAAGGAGGGAAGAAAAGAAAGCAAAGGAACAGAAGGAAG GAAAGAAAGATGGGAGGAAGTGCAGCAGGAATAGCACCCTCTCCCCGGGAGGCCCTAGCT TCCGTGAGGGGCCATCACCAGCCATTCCTTGGAGGGGGCTTTCTCCCCTTTTGCTTGAGC AGGGTTCCCAGGAGGGAGAAAGAGAAGACAAGAGCCTGATGCCCAACTTTGTGTGTGTGG GGACGGGGGAGTCAGGGCCCCCCAAGTCCCACAATAGCCCCAATGTTTGCCTATCCACCT CCCCCAAGCCCCTTTACCTATGCTGCTGCTAACGCTGCTGCTGCTGCTGCTGCTGCTTAA AGGCTCATGCTTGGAGTGGGGACTGGTCGGTGCCCAGAAAGTCTCTTCTGCCACTGACGC CCCCATCAGGGATTGGGCCTTCTTTCCCCCTTCCTTTCTGTGTCTCCTGCCTCATCGGCC TGCCATGACCTGCAGCCAAGCCCAGCCCCGTGGGGAAGGGGAGAAAGTGGGGGATGGCTA AGAAAGCTGGGAGATAGGGAACAGAAGAGGGTAGTGGGTGGGCTAGGGGGGCTGCCTTAT TTAAAGTGGTTGTTTATGATTCTTATACTAATTTATACAAAGATATTAAGGCCCTGTTCA TTAAGAAATTGTTCCCTTCCCCTGTGTTCAATGTTTGTAAAGATTGTTCTGTGTAAATAT GTCTTTATAATAAACAGTTAAAAGCTGACAGTTCGCCCTTACTCTTGGAGGTCATGTTCA GGAGGGGCATTCCTTTCCCCTGGGGGTCATGGGTGTCCCCATGCCCACATATTGCACGTG CAGGGAGGTAAGTGCCTGCATCCCAAATCGGTTCTAGGTCAACTGGCCTCAAACTGATTT GCCATGAGCTCACAAAATGAATCCCTATGCTTAATGACCAGGTCACATAAAATCCAGCCC ACTTACAGGTTTTCTGGCATCTGTTTGGGTGTCCTAATTTTTTTGGCAGTGTCATTTGAA GAATTTTTTTAAAGCAGTTTATTTAAGAACATACTGATTAAATGCAGGATCGCTACTAAA AATTGTTTTGTATCCTTGGTGGGTGTCTTCTGCTATTTTATCTACTTTTGAACACTTTCA GGACTTTTTAGCCAGTTTGCCTTTCTTGAAAAATGTTATGTTTTCAGCAATAAATACATT TGATAATGACTTTGTTTGTATCATTTTATGTTTCACAAAGTAGAGTTGCTTGATGAATGA GATAGCCTGAAAAATAAAATGCAAAGAGTTCAATATAA OMIM ID 300297