Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MBD4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 8930 Official gene symbol MBD4 Full name methyl-CpG binding domain protein 4 Aliases ,MED1, Gene summary DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MBD4 may function to mediate the biological consequences of the methylation signal. In addition, MBD4 has protein sequence similarity to bacterial DNA repair enzymes and thus may have some function in DNA repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective DNA mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene. [provided by RefSeq] Location Chromosome: 3   Locus: 3q21-q22 Gene position 129158852 - 129149793  Map Viewer Gene orientation minus Gene size 9060 bp Gene sequence >MBD4:complement(35644939..35653998):Length=9060 GGCGGCTGTAGCCGAGGGGGCGGCCGGAAAGCAGCGGCGGCGTCTGGGGCGCTTTCGCAA CATTCAGACCTCGGTTGCAGCCCGGTGCCGTGAGCTGAAGAGGTTTCACATCTTACTCCG CCCCACACCCTGGGCGTTGCGGCGCTGGGCTCGTTGCTGCAGCCGGACCCTGCTCGATGG GCACGACTGGGCTGGAGAGTCTGAGTCTGGGGGACCGCGGAGCTGCCCCCACCGTCACCT CTAGTGAGCGCCTAGTCCCAGACCCGCCGAATGACCTCCGGTAAGTTACTGTCCCCTTTT GGGCCTCAGTTTCACCACCTGTAAAATGGTATCGGGAGAGTGGACAGTGTGTGGGCCTTT CTAACCTTTGACAGAGGGTCGGCAGAAACCTCGAAGCCCACGGGTTTAGTTACTAGGGTC TGGAGCCCAGGTGCTCTTCCTGTGCGATCAGCCCTGGGGTGCGCTCGACTTCCTCATCTA AGATGACTAGGGAGACTGGGGGGGAGCCGGGAGGTTTTGTGAAAGAGGTCCCCTTGGGGT TGGAGGATCCTAGGAAGTCATTAGACTACGTGTGTGATAGGAGGTTAAGATTTACCTACT TTTTTCAAAATTTAATACTAAGAACTACTTTGAAAGAGGCATCACCTTCTTTTTACAGAG TCTTTTACCGAGACTTTGAGATGTTAAGTAACTTGCTGCTAAACTTACAGCTGGTAGAGC TGGAATTTGAGCCCCAGTCTCTTAAGAGTTTGTGCTGATTCCACCAGGCTTCAGTATTTT TATCTCTAAAATTGTAAACAATATCATTTCATAAGATCCATCCAGCTCCTCAAAATTATT TTACCCCAAATTACATCAGAAAACCTTGATTCTAATTCTAGTTCTTGCAGTTTCCCTATT TGTAGAAAAGAACTTGGGTTAAATGATCTCTCTAGACCCATCCACCTTTTACAATCTGTG GTTTAGTGATTAGGATACACTTTACTGAAATTTTTTTTTTAATTTTAAAAGTATGTTTTC ATCATAGAAGACACATTGGAACTTTAATGAAGTTTTAGTTTAGTGGGTTTTTTTTTGAGA TGAGGTCTCGCTCTGTCACCCAGGCTGGAGTGCAGTGGCACAATCATAGCTCCCTGAAGC CTTGACCTGCCGGACTTAAGCAGTCCTCCTACCCCGGCCTCCTTAGTAGCTGGGACCACA GGTATGCTCCACCACGCCCGGTTGCTTGTTTTTTTTTGTTTTTTTGGGTTTTTTTTTTCA TTTTTTGCAAAGACGAGGATCTCACTGTGCTCTCCAGGCTGGTCTCAAACTCTTGGGATC AGGTGATCTTCCCACTTCCTCCTCCCAAAGTGCTAGCATTACAGGAATGAGCCACCTTGC CTTGCCAGCTTTTTTCAATAACAGTATGGGGGAGAAGTATTAGACCAAGATTTGGTAGAC TTGGGTTCTCGTGTCTGTTCTGCAAGTAATTTAACCTGTCACTCAATTTTATCAATAAAT TGAGAGTAAACCTTATTGTACCTACAAGGTTACCATGAGGATCAAGAATGAAGAAGATTC AAAAATTCTGTATCAAATTATTTACCTTCTGGAGGATTACATCTGATGAAAGTGATACAC ACTCTCTCCCAGAAATTTTACATTATGTAAAACTTTTACCTCATTTATTTGCAGAGAAGA CAGTGTAACTCACTGATTTATTTAAGCATTTTCTGGTGCTTAAGAGCTTAGCTATTGGTT CATATTCTCAAATTTATGGTAAGTGCCCCCAGAAATCTTTATAATAGCCCTACTCAGTGA TTAATCCGAAAAGTTTCTAGCTTGACTTTTTTGTTGTGCAGAGATTTCCAACACCTTTTA ACCTGTGCTAGAGGATATGGGAAGCTTTTGGAAGACAGGAAAATACTCCCATAGCACAAG ACTGGTCCACACTGACTTTAATCTCCCTCATTTTAATATGGATAATCTATGTGGTTCCTG CATTGTCATGGATTAAAACTGAGTAGGCAGTGGAAGATAAATTTTAAATAAGTTAATCAC TTAGACTTTGTTTTTCCAGCAAAGAAGATGTTGCTATGGAATTGGAAAGAGTGGGAGAAG ATGAGGAACAAATGATGATAAAAAGAAGCAGTGAATGTAATCCCTTGCTACAAGAACCCA TCGCTTCTGCTCAGTTTGGTGCTACTGCAGGAACAGAATGCCGTAAGTCTGTCCCATGTG GATGGGAAAGAGTTGTGAAGCAAAGGTTATTTGGGAAGACAGCAGGAAGATTTGATGTGT ACTTTATCAGGTAAGCATATAAGATGGTAAAGATAGTACAGCCAAATGATTTTGTCTGGG CAGGTAGTGGGAGCATAGCAGGAATCTTAGCTTCTTTATATTTTTACCATAAAACCATTG CAGATTCTATTCTTTCAATGTTGCTATTAATTACATCAAGTGATTTGGGGAAAATTACAT ACATTTTGTCCCTCCTTCTGTGAATGGTTAACGGGTAGGTTGCATTTTAGTTATATTTAT AAATTTATATTGTCATAGAGGAAACCATTTAAAAGTGCCATTTATCACTCTTTTTCATTT TTAAATGACAGATACCTATGGCAACATTTGGAAATTAATTAGAAATCTGAAATGTGGTCC AGTTCTTTTAAAAGTCCCTTCTATTTACTAGCAGTAAGTTTCCTTTAATATCATTTTCTA GCCCACAAGGACTGAAGTTCAGATCCAAAAGTTCACTTGCTAATTATCTTCACAAAAATG GAGAGACTTCTCTTAAGCCAGAAGATTTTGATTTTACTGTACTTTCTAAAAGGGGTATCA AGTCAAGATATAAAGACTGCAGCATGGCAGCCCTGACATCCCATCTACAAAACCAAAGTA ACAATTCAAACTGGAACCTCAGGACCCGAAGCAAGTGCAAAAAGGATGTGTTTATGCCGC CAAGTAGTAGTTCAGAGTTGCAGGAGAGCAGAGGACTCTCTAACTTTACTTCCACTCATT TGCTTTTGAAAGAAGATGAGGGTGTTGATGATGTTAACTTCAGAAAGGTTAGAAAGCCCA AAGGAAAGGTGACTATTTTGAAAGGAATCCCAATTAAGAAAACTAAAAAAGGATGTAGGA AGAGCTGTTCAGGTTTTGTTCAAAGTGATAGCAAAAGAGAATCTGTGTGTAATAAAGCAG ATGCTGAAAGTGAACCTGTTGCACAAAAAAGTCAGCTTGATAGAACTGTCTGCATTTCTG ATGCTGGAGCATGTGGTGAGACCCTCAGTGTGACCAGTGAAGAAAACAGCCTTGTAAAAA AAAAAGAAAGATCATTGAGTTCAGGATCAAATTTTTGTTCTGAACAAAAAACTTCTGGCA TCATAAACAAATTTTGTTCAGCCAAAGACTCAGAACACAACGAGAAGTATGAGGATACCT TTTTAGAATCTGAAGAAATCGGAACAAAAGTAGAAGTTGTGGAAAGGAAAGAACATTTGC ATACTGACATTTTAAAACGTGGCTCTGAAATGGACAACAACTGCTCACCAACCAGGAAAG ACTTCACTGGTGAGAAAATATTTCAAGGTATCCAGTGCTTTCAAGCACTATTAAACATTA TGTGATGAGAAATTTATAATGCTGCATCTTGTATTCGTGCCCATACATGGTTAAGATGTG AAAATAGAGCCAAGAAATAGGGCCAAATATGAGATACCAGTTGATCCTAATACTTTATCT TAAACTGATATTCAAGCAGTTTCCTATGGCAGAGAGAAAATCGGCTGACTGCTGTCGTGA TGCCATGGCAAAGGAGAGTATTACTATTAACAGCTGCCATCGTCTCTCCCTGGTGCAGCA GCTGGGACTCTCCTCCTCAGCAGTGCTTTCCCTTCTTCCCATCCTCTTTCCAGCCAGTAA TCTTAAAACTTGAAGGAAAATTAAAAGCCTTCACTTGTGAAAAATTTAGGGAAGGCTTCT TATATACATAAATGAGTGGAGAATAGTTGGTGTCTTCACACCCCTCCTGATACTTACTAC TAAGTGTGACTTCCAATTTAATTTTGTATATATCATAGTCATTTTTATCTTCTATTTTAA TGTAATGCTTCTCTAAAATGCTTTAGAGCTCTAAATAATTCAAAAGTATAATCACATAGT TCATCTATTATTTGTAATATGCTCTTAATACAGAATTCAGAACTTAGCAGTTTTGTCTTT ATAATACCTCAGTGAATAAGAGATAAAAGGGAGACCTTTTGAGCAGCCCTGTATTAGTTA TTCATTATGCCATTATGGTATAATGAATAACTCCTTTAAAGAATAATAATTTTACTTAAA CTCCTGTGGGGAAACAGCCTGGAGAAATTTGTGAAGCAGGAGATTAGGTTTGATTCTTGT TCCCAGTTCTACCCATGATTTTATGTCTTTTCTGTGCCTGGAGTTTCTCTGCCTTTAACA CAAGATGGCCATATATACCTAGGAACTGCATAAGAATTCTTCAAGTCTGTGTCCTAGACA CTGAGCTTCTTGAAGAAAGCTTTGAGGTTTATGTAGATTTATTGCTAGCAAAATGGGCAA ATATTAAAAACTTTTTTTTGTGGTAAGAGTCTAGTTCTCAACATGAGATGAAGTACTCTT AGTACGAGGTGTCCATGAAATAGTGAAGACACCCATTGGCTTAGCTAGAAATTGCCAAGT AAACCTGGCATAAAGGAGACTAGTAATTATTCATAGGAGCCCACAGAAAAAGTTGTCAAA TCAGAGCAGTCAGAGCAGTTTCCTTTGTTCTTTTTTTTTTTTACTCTCTACTGGGCTTTA CCTACTCAAACTAAAATAGCGAAAAAACAGTAGTCTAATTATCTGGAGACCTGGATACTT GTTCCAGTTTATAGTCAATCCCAGTATCATTTTGGGATGATTGCTTCATTTAGAAGCTTC ACTTTCTTCATCTGTAAAATAGAGGTAACCATCCTGACTAGTCCTGTTTTTCACATCAAA AATATTGTAAAATGAGAAGTGAAAAAGATGCTATACAAATGCAAGGTATTATTAACTGAT ATTCAAATTGCGAGGGTATGGTTAAGGAGTATTACATGTGATTTTAGAAATTTGAGAAGT CTGATAACACTGGTTCCCAATAGATAGAGGTTCTCAATAGGTAGTTGTCTCAGGTGTTCT AGGGTTCAAATTGTAGGTTTTTCTGCAGATTCTGTTTTGTCTGTATCCCTTTTTTTGGTA AGCGTAAAAGTAAGTGTTCACTGCAGAAATTTTGGAAAATACAGAAAAGTAAAGAAGGAA AGAAAAATTAGCACTTGGCAACAACCATTATATCATTTTGGCTTATTTCATTCTTAACTT CTGTATTGTTATTTATATATGTTTCCCCTTTTTTATAAAATTGGGATCATATGTAGACTC TTGCTTTTTCATTTAGAAGTTAATAGGAAAATATTCACAATAGTCTAAAAAATACTTTAA TGACCACATTATACAAATGCATCGTAATTTAAAATATTCCATACTGCCTTTAATTTTTCA ATACTATAAACTCTGAACATAAGTCATAAAGAACTAGTGTCACAGAGTGGTTAAAGGTGA GGACTCAGGAGCCAGACTGTCTGGATTTGAATTTTAGCTGGGACACTTAGTATCTGTGTG ATCTTGAGCAAGTTACTTAGCTTCTCTGTGCCTCAATGTCCTTATCTGTAAAGTGGAGAT AAAAATAGTACCAAGTTCATGGGTCATTAGTTAGATTAATTGGGTATTTATGTAAAGGGC TTAGAATAGTGCCTGGCATGCTTTGTAATAGTGTTGATATTATTATTTGCATCCCTCAAT ATTGCTTTAAGCTAAACCATAGACTCCATAAAGTGTTTACTTTTCCTTTTCAGAAGATAC CATCCCACGAACACAGATAGAAAGAAGGAAAACAAGCCTGTATTTTTCCAGCAAATATAA CAAAGAAGGTATCCCTTTCCCAATCAGAACAGCAAATTCTAATTCCATTTTGGGTTTTCA ATTCTGATGCACTATGTTTGTTTAGCTCTTAGCCCCCCACGACGTAAAGCCTTTAAGAAA TGGACACCTCCTCGGTCACCTTTTAATCTCGTTCAAGAAACACTTTTTCATGATCCATGG AAGCTTCTCATCGCTACTATATTTCTCAATCGGACCTCAGGTTTGGGGATTATTATCATC TTTGTCTTAGTAGAGACAGTGTGGTAGGGAGAAAGCACTGAATTGAGGCCTGGGTTCAAA GTCCATTTTGAGTGTGTCACCTGGGATAGGGCATTCCCCCTTCACCCTTAAACTCTTCAC CTATGAGGAAATGAGACTGGATGACATCCAACAGACCTTTTAGAATAAAGAGGTAGATTT TATTTATTTTATACTTCCAAATTCTTTTTGATCATCAGTGAAAATCAGTTAACGTTTCTC CACCCTCTTTCATGTGTGTTTAAAAGTATCTTTTTCACTGAATGTACCTTGTGTTCTATA TGCTTCTACTCTCATTATCTGCTGATCTGATCATTTAAAAGCTAATCATGCAAGGCCAGT TTTCAGCATAATTTGGACTATTAGCCCAATATATTAGCAGTTTTGGCATTTGATTCTGAA AGTGGTTGCTGGTTCAGATAATGGCTTCTCACCAGTGTTTTTTTGTTTTTTGTTTTCTTT AAAAAAAAAAACCCTCTGGATGAGATTTCTATGAGAAACTACTTGAACATGAAATCAGCC CACCTGGAGTCTTGTAATCATTCAGTTACTTTTACTTCCCAGGCAAAATGGCAATACCTG TGCTTTGGAAGTTTCTGGAGAAGTATCCTTCAGCTGAGGTAGCAAGAACCGCAGACTGGA GAGATGTGTCAGAACTTCTTAAACCTCTTGGTCTCTACGATCTTCGGGCAAAAACCATTG TCAAGTTCTCAGGTATTTTCCTATACACCCAAAGGAAAAACATAATACATTGTGCTTATT TAAGAGAGCCACACCTTAAACTTTAATGTTCTCAGATACTATATTAATGGAGGTTTTTCA GCTCAAGCACCCAAGGCATTTAAAAAAGTCCACTTTCCCCAAACCACAGTCTCCCACTGA CCTAAACAATAAATCTTTGCCCAGCACTGGGTCAGGCATGTGGGCAGAATTAGGGGAAGA AGTCAGTGAAGCAGAAAGCCCAGTTCTTGACCTCAAGGACATGACTTCTGTCTTGTTAGC ACAGCACAAAAGAGTGGTTAGGAATTGGCAAATGATATGGGTGCTGCAGGAATTCAGAAG GAAGAGTAATCACAACTGGGGTTGCTGGGAAAGAGCCTTTCCTGTCCCTTTCTGCTGTTC TCTCCATCCTGCCCCATCACCACACATTTTGGGAGGGTGTCTTTAGAAGCTGACCTGATA ATGTGGGATGTTGTATTCTTCAGATGAATACCTGACAAAGCAGTGGAAGTATCCAATTGA GCTTCATGGGATTGGTAAATATGGCAACGACTCTTACCGAATTTTTTGTGTCAATGAGTG GAAGCAGGTGAGGCTCACTCCCATCCATAATTCAGCACATTTGGTCTCTGAGGCAAAATA AGTCCACCATTATGGTTAAGACTATTTATTGGATACAAATGCTATTACAGTCACAAACAA TTGTGTTCCTGGCTGCGGGGAAGCGGGTGGCATGTGGGTTTTGGGGTTTTTGATCAGTAG GCGCTCCCAAGTCCACAAAGACCAGTCCAGCGGCGTGGCCTCTGACTCATCTCCAGTGGT TTGTCACCTCTGGCCCTGTTCCTGTCATTCCCTATTTGTGTGCTATCTCTAAGCCTGACG TGGTTTTCCTCCTGTCAAAAGTACACCACTACAGGAAAGCAGGAAGGTTTGGGCCTGCAA TGTATGCATATTGGGTTTCTCTTAGTGGTCTCAGACTACGTTTGTGGTGACTGGGTCCTG CTTCAGCCCTGTTGAATATGCCCAGCCTGTGGCATGCTGGTGGTCATCCTGGCAGCTGGT GGGTGGCCTGGTATGCTGCCCACTCAGCTTGAGACTCACCCTCATGCATTCAGCCAGTAG GTCTGGCCAAGCCTGAACTGAAGGACCATGGTCCTATCCCAGCTTCATCAGAGCAATCCA TTGTGACCTGAGAATCCATTTAACCTCTCGGTCTAGAACCTCCTTCTGGAAAGTGAGGTA TTAATACTTGACTCATGTTATCGCCACCCCACATTCTAAGTCATGGTTGAGTAGTAATTT GGACAGTACCTTGTAAATTGTGTGAGATTACCTTAATATAAGGTATAACTTAAAATATTC ATGAATCCCAGGAGGTTAAAGGTTATAACTTTTAGGTATGGTATCGTAATGTACTGTCCC CCAGCAAACATTTAAAAAGCCAATTTTAAAAAATGTATTTCTGACTAAGTTACATTAAGG TCTCTGCCTCTGTATCTTATGTTTCTTCCAGGTGCACCCTGAAGACCACAAATTAAATAA ATATCATGACTGGCTTTGGGAAAATCATGAAAAATTAAGTCTATCTTAAACTCTGCAGCT TTCAAGCTCATCTGTTATGCATAGCTTTGCACTTCAAAAAAGCTTAATTAAGTACAACCA ACCACCTTTCCAGCCATAGAGATTTTAATTAGCCCAACTAGAAGCCTAGTGTGTGTGCTT TCTTAATGTGTGTGCCAATGGTGGATCTTTGCTACTGAATGTGTTTGAACATGTTTTGAG ATTTTTTTAAAATAAATTATTATTTGACAACAATCCAAAAAAAATACGGCTTTTCCAATG ATGAAATATAATCAGAAGATGAAAAATAGTTCTAAACTATCAATAATACAAAGCAAATTT CTATCAGCCTTGCTAAAGCTAGGGGCCCACTAAATATTTTTATCGGCTAGGCGTGGTGGT GCATGCCTGTAATCTCGGAAGGCTGAGGCAGGAGGATCATTTGAGCTCATGAGGGCCCAG GAGGTCAAGGCTTCAGTGAGCCATGATCATGCCACTGCACTCCAGTCTGGATGACAGAGA GAGACCCTGTCTCAAAAAATATATATTTAAAAAATAAAAATAAAAGCTGACCCCAAAGAC OMIM ID 603574