Database of mammalian genes
Home

Home Search Browse Statistics User guide FAQs Links Questions Contribute Download


Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CCND2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID894
Official gene symbolCCND2
Full namecyclin D2
Aliases,KIAK0002,MGC102758,
Gene summaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p13
Gene position4382902 - 4414522  Map Viewer
Gene orientationplus
Gene size31621 bp
Gene sequence
OMIM ID123833