Home

Search

Browse

Statistics

User guide

FAQs

Links

Questions

Contribute

Download

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SIGLEC12 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 89858 Official gene symbol SIGLEC12 Full name sialic acid binding Ig-like lectin 12 Aliases ,FLJ38600,S2V,SIGLECL1,SLG,Siglec-XII, Gene summary Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq] Location Chromosome: 19   Locus: 19q13.4 Gene position 52005043 - 51994613  Map Viewer Gene orientation minus Gene size 10431 bp Gene sequence >SIGLEC12:complement(24262831..24273261):Length=10431 GAAGAACCCTGAGGAACAGACTTACCTCAGCAACCCTGGCACCTCCAACCCGACACATGC TACTGCTGCTGCTACTGCTGCCACCCCTGCTCTGTGGGAGAGTGGGGGCTAAGGAACAGA AGGATTACCTGCTGACAATGCAGAAGTCCGTGACGGTGCAGGAGGGCCTGTGTGTCTCTG TGCTTTGCTCCTTCTCCTACCCCCAAAATGGCTGGACTGCCTCCGATCCAGTTCATGGCT ACTGGTTCCGGGCAGGGGACCATGTAAGCCGGAACATTCCAGTGGCCACAAACAACCCAG CTCGAGCAGTGCAGGAGGAGACTCGGGACCGATTCCACCTCCTTGGGGACCCACAGAACA AGGATTGTACCCTGAGCATCAGAGACACCAGAGAGAGTGATGCAGGGACATACGTCTTTT GTGTAGAGAGAGGAAATATGAAATGGAATTATAAATATGACCAGCTCTCTGTGAATGTGA CAGGTAAGGCACGGGCTCCAAGAGAGGCCAAAGGCAAATGTGATGAGGGCTTTAGGGCAC GGCTGAGACGGGACACATGTCCTGGGAGGGGGCCGGGGGTGATGGACTCAGGGGAGGAGC TGGACCAGAGCCTGAGCTTCCCCAGGACCGCACCTTGGATGCCCCTCCTGATCCTGCAAG CCCCTCCCCTCACCAGCCCTGACCCACAGGCCTGACATCCTCATCCTGCCTCTGACGCTG GCACTGTGGCATGTGGGGCCTTATGACTCCTTGTTTTGGGGCCTGTCCTAGGCATGGCCG GGGTTTAGCACCATCCCAGGCCTCTCCCCACCAGATGCCAGAAGCACCCACCCCACCCAT GCAGCGAGACAATTATCTCCACACATTGTCAAACGTCCTGGGGGGTTAAGTCCTCCCCAG TTGAGAGCCTTAGGTCTACACAACCCCGTGACTCTCTCAGGCCAGGCCAGGGAGGAAGCA CTTCCTGGCGCAAACCAAGGGCAGCAGAGGCACCTGAGCCTGGACAGGGAGACTCAGCAC ACGGCCCCTCCATCTCTCATGCCCCGAGGTCCTCGGAGATCCACATTTAGATGCTCAAAA GACAGGAGGGACCTCCACGATGGTCCAGAGGCCGGGAGGGCAGGACCTACGTGTCTGGTG CAGGCCCTGGTGCTTCAGGGAAGCCCGGAGGTAGGAGGCGGGACACGGTCTCTTCTCCTC CCTGGGTGGGTCTCTAGGGTCTCTGAGCTTTAGGGTTTCCTTCACTCTGTGCAGAGGGAA TGAGTTCCTATAGCATGTGGGTTTGCAGTTTCTCTTCCATGCAGGGCTGAGGTCTCCAGC TCCTCTCCAGCCCCCTGTGGGTCCCACAGCCCTGCCCCTCCTCTCCCTCCCCCTTCTCTG CTCACACAGGGAGCCCAGGAAGCCTCTGCCTCAGAGATGCTGCTGCCCCTGCTATGGGCA AATGAAGAGAGGGACAGTGGGGGCTGGGCTGACCCTCGTTTCTCCACAGCGTCCCAGGAC CTACTGTCAAGATACAGGCTGGAGGTGCCAGAGTCGGTGACTGTGCAGGAGGGTCTGTGT GTCTCTGTGCCCTGCAGTGTCCTTTACCCCCATTACAACTGGACTGCCTCTAGCCCTGTT TATGGATCCTGGTTCAAGGAAGGGGCCGATATACCATGGGATATTCCAGTGGCCACAAAC ACCCCAAGTGGAAAAGTGCAAGAGGATACCCACGGTCGATTCCTCCTCCTTGGGGACCCA CAGACCAACAACTGCTCCCTGAGCATCAGAGATGCCAGGAAGGGGGATTCAGGGAAGTAC TACTTCCAGGTGGAGAGAGGAAGCAGGAAATGGAACTACATATATGACAAGCTCTCTGTG CATGTGACAGGTAAATCTCTGGCTCTAGGACCAGCCAGAGGGGAAGGCCCGAGGGCCGCA GGGTAGGGCTGAGGTGGGACCCCCATCCTGGGAGGGAGTTGGAGGTGAAGCATATCTGGC TCAGGGGAGGAGTAAGACCAGAGCCTGAGCCTCCTCAGCACCACACTTCAGACCCCAACA CCCTCATTTTGCCTGTCTCCCTTTCATCACCAGCCCTGACTCACATGCCCACCTTCTCCA TCCCGGGGACCCTGGAGTCTGGCCACCCCAGGAACCTGACCTGCTCTGTGCCCTGGGCCT GTGAACAGGGGACGCCCCCCACGATCACCTGGATGGGGGCCTCCGTGTCCTCCCTGGACC CCACTATCACTCGCTCCTCGATGCTCAGCCTCATCCCACAGCCCCAGGACCATGGCACCA GCCTCACCTGTCAGGTGACCTTGCCTGGGGCCGGCGTGACCATGACCAGGGCTGTCCGAC TCAACATATCCTGTGAGTTCTGGGCCAGGACGTCTGGGTCTTTGATCGGGATTCCTTGAG GCCAGTTGGATGTGGGACCCAGACTCAAGGATCTGGGTCCTGGAATCTTGGCTGGGAGTT GGGGGTCAGGAGGATGCTGGCTCCACCTTCCCCATTTATGGGGCTCCTGGGGAGACAGGG TCAGTGTCCCCAGTCCTCAAAGTGATGGGAACTCCGTGTCTTTCTGTTCCAGATCCTCCT CAGAACTTGACCATGACTGTCTTCCAAGGAGATGGCACAGGTAAGATGGAGTCCTCTCCC TGGGGCTGGAGGAGCAGAGCCTTCAACTCAGGGGAGAGCCAGGACTCACCCTGGTGACCT GAGACCCTTTTGTGGGTGAGCCCCGGCCCCCCCCTCCCTCAGCCTCAGCCTTTTGGCCAC CTGAGCACCTTCTCATCACCCCTTCACTCCCCTTGAACTCCTCCACACACACACCTATTT TGGCCCCACAGCAAGGGTAGAGGGACATTCACACAGCAGCTCAAGGATTTGAGGACTCTT ATCTTCCAGCTCCTGAATATTGCCTCATCCTTTTATTTTCACCAATAGTTCTGAGGTATA TTCTTTTGGATACATACTATAGTCACATGGGCAAAAATTTATAATGCACAGCAGAGTCTG TCCCCAGAATCGACCAGGGTCTGTCCAGGCTGTCCTGAGCCTTGGTTTGTGCACCTGGAA GATCTCAGAGGTGGTTTGATGTCAGTAGTGAGACTGTTTGCACCCTCCTCTAGGGCTGTG TGTCATTCCACTGTCTGAATAGTCTCTGATTTTGTGGCATCTTCTAATGGAAGATCATGG CACTAATTTTATCCTACAGCACAAACACTGCAATGAATATTGTTGTATCTACTCCCACAA GGAATATCTAAGTGTATGGAATAAAGTCCTAAAAGCAAAATATAGCAGTGTCATATGTCT TTCTGATTTTGAAAGATAGAGTGAAATTGTTCTAATTAAAGATGGACAAGTTTACATCCC CAACAGTGAGCAGTGAACGTGCATATGTCCCTACAATTCAGCATGTATCAGTGTCTGTTC CATTCACCACTCTCTTTCTGTATCCTTCCTCCCTGCCTCGATCACTTTGTCTCTCTCTGC CCTTCTGTCTCTTTCTCTACAGCATCCACAACCTTGAGGAATGGCTCGGCCCTTTCAGTC CTGGAGGGCCAGTCCCTGCACCTTGTCTGTGCTGTCGACAGCAATCCCCCTGCCAGGCTG AGCTGGACCTGGGGGAGCCTGACCCTGAGCCCCTCACAGTCCTCGAACCTTGGGGTGCTG GAGCTGCCTCGAGTGCATGTGAAGGATGAAGGGGAATTCACCTGCCGAGCTCAGAACCCT CTAGGCTCCCAGCACATTTCCCTGAGCCTCTCCCTGCAAAACGAGTACACAGGTGGGTAG GGGAGGGTCTGGAGGAGGAGAACACACATGTCCCACCCTCAGGGTCCAGCTGGGAGACCT GGAATTTCCCTGCAACCCACAGCATCACAGTCCTCTTGCTGCCAAGCAGTGAGTGCGGGG TGGGGAGAGGGGAGGAGTTAATCTTGGAGGGGAGGAGCTGGGGCCTGGACAAGTGTGTTT GGGGATACAAGGGCCTTGCTTTCCAGTGCCTGGACTAGTGTGAGGCAAGTGAGGCACTCA CTTTGGGCACACAATTTAAGAACCAAAAATAAAACAACTCAGCAAGCAAGAGAAATAATC TTGCCATGTGATTATCTTTTCGAAAATTAAAAATTATTGTAAAATAATTCCATGGTGAAA ACTAATCAAAATTTTAAATAAAGGCAGACTGCACCCAGCACTCTCATGCCTCAGTGACCT CAGGAGAAGTTCCCTTCCGTCCTTGTTCTTTCTGTCCGGGAAGCGGGACTGGGGTACCCA AGTCTGGGGCCCTACAGGCAGTGGGAGGAGAAGAGGCCCAGTTCTTGGAGGGTAAACCCC AAAACAACTCCAATCCATCCTCAGGCAAAATGAGGCCTATATCAGGAGTGACGCTAGGGG CATTCGGGGGAGCTGGAGCCACAGCCCTGGTCTTCCTGTACTTCTGCATCATCTTCGTTG TGTGAGCATTGACCCTGGGGAGGAAGAGCCTTGGGGGAGGGCAGGCTGGGAACAAAATCC CTGAAGCCAGACCTGGAAGGACCTGGATGGGTCAAGAGCTTGAAGCAAGGGCCAGAATGA GGTCATGGGTGCATGGTAAGAATTTCATGAGCGCCCCTGTTTGTGGAGCTCCATGTCTGT GGCAAACCTCAGACCCTACTGCCCAGGAAAAAAGAGCCTCTGTTTTCGACATTGGGGTCT CTGGAATGGGACCACTCCCCTCCCGCCTCAGTTACCCCTCCAGCTCCCCAATAGGAAATA CAGGGCAGGGGTTGGTCTGCCCACTGCACCCCGATCTGACCACACTGAAAGGCTCTCTGG TCTCTTCACTCAGAGTGAGGTCCTGCAGGAAGAAATCGGCAAGGCCAGCAGTGGGCGTGG GGGATACAGGCATGGAGGACGCAAACGCTGTCAGGGGCTCAGCCTCTCAGGTGAGTGAGC ATTGAATCACAGCCCTTCTCCCCTGCTTTCTCCCAGGCCAGGCATGGAAGGGGATTACTT CCTCACTGTCCTTCCTTTCTTCCCCTACAGCCGAAAAATCACGTCCTGTCCACTTTTTCC TCCTAAGAACAGCTTTCATTGCCCTCCCCATCCCATCCTGACCCCTCTCACTGCTGAAGC CTCTGGATCTCTGTCTGGGACCTCCTCACCTCCCTGCCTCTTGCCTCCCCTTCCCGGCCT GGAGGGACGTTCCACAGCCATCACTGTCTGCTTCCTCTGCACGTTGAATAGCTTTTGCTT CAAGTTCCATTTGGCTCAGCAGAGCACTGTCACTAATCTGGGTTTATTTAAATCTTTGTT CTCCAGGAATTTTTTGTTTTTATTTTTATTTATTTATTTATTTTGAGACAGAGTTTTGAT CTTGTTGCCCAGGCTGAAGTGCGATGGTGCGATCTCAGCTCACCACAACCTCCACCTCCC GGGTTCAAGTAATTCTGCCTCAGTCTCTCGAGTAGCTGGGATTACATACACGAGCCACCA TGCCCGGCTAATTTTGTATTTTTAGTAGAGACGGAGTTTCTCCATGTTGGTCAGGCTGGT CTCAAACTCCCAACCTCAGGTGATCGCCTGCCTCAGCTTCCCAAAGTGCTGGGATTATAG GCGTGAGCCACCGCGCCCAGGCTTTCCATGGACTTTTTATATTAATTTTGATTTTTTAAA TATTGTGTTAAAATTGTATTCATCTTCATTGCTGAGATTTGGGGCACCCTTTTAATTTTG TGCTCTGGGTAAGGGCTTCCCTGGCTTTGCTCCAATCCCAGCCCCGCCTCCAGCCACTCC TGCCTCTGCTCCATGCTCCATCAACGCTGGACTCCAGTGTCATCACCAACAAGGTTATTT GTGTCTCTACGTCTTCACATTGGCTGTTCCTCCTCCTCAGATGCTTTTTTCTCCCCACTC CCTGATTCCTATTCATCCTTCATGCCCTGATATAAATATTACACTCATCATTTATTGATT GTATTGAATGTGACTGGAAGCCTGTGGAAGGTTTCGAGTAGCAGAGTAACATCCATCCCT TCATTCATTAATTCATTCAGGAAAAGTTATAGAGCATCTCCTAAGAGAAGATGCCAGCGA CCCATCTGTGGAAAACATTTAAAAGTCTTGGGCTCATCGAAGTTTAATTCTATACAGAGG GATATGGCCAAACCAATCAACTAATCAAAACTAATAAAACAACAAATGAATAAAATATAA AGATAGATATATGCTTTAGGGAAAATGCAATGTAGAAGAAATAGGAAGTTCCAAGGAGAA GGCTTGTGGGTTTATTTTTGTTTATTCATCCAACCATTCATCCATCCATCCATCTGTCCG TCTGTCCGTCCGTCCATCCATCCAACCACCCACCCACCCGTCAGTCCATCCATCCATCCA TCCATCCATCCATCCACCCACCCACCCACCCATCCATCCATCCATCCATCCATCCATCCA TCCACCCACCCGTCTGTCCATCCATCCATCCATCCATCCATCCATCCATCCATCCACCCA CCCGTCCGTCCGTCCATCCATCCATCCATCCATCCATCCATCCATCCACCCACCCACCCG TCCATCCATCCATCCATCCATCCATCCATCCACCCACCCACCCGTCCGTCCATCCATCCA TCCATCCATCCATCCATCCACCCACCCACCCGTCCATCCATCCATCCACCCATCCATCCA TCCAGCCATCTACGGTGGAAAATAACACATAACATAAAATTTACCACCTCAACTTTATTA AGTTTATGGTTGTGCTAGATCTCTAGAACCCTTTTATCTTGCAAAACTGAAACTCCACAT TCGTTGAACAATAACTCCGCCCTTTCCCTCCCATCCTCTTCATCCTCCTGCAGCCACTGG AAATCACCAATTTTACTTTATTTTCCTATGAATTTGACTATTCTAGATACCTCATATAAG TGAAATCATACAGTATTGCTCATCTTGTGACTGGACGATTTACTTAACAAATATCCTCAA GGTTCACCCACATTGTAAGGTGTGACAAGATTTCCTTCTTTTTAAAGGGTAATTAATATT GCATTGTGTGTATGTTTACCGCATTTTCTTTATCCATTTATCTGTTGATGTACACTTGGG TTGCTTCCACCTCTTGGTTATTGTGAATAATGCTGCCGTGAGCATGGGCATGCAAATATC TTTTCAATATCCTGCTTTTAATTCTTTTGGGTGTATATCCACAAGTAGGGTTTCTGGACT CTAAGATTATTCTGTTTTTTAATATCTTAAGGAACTGCCATACTGTTTTCCACAGTGGCT ACACTATTTTACATTCCCACAAATGTCACACAAGGGTTCCCATTTCTCCACATCCTCACC AACGCTTGTTACTTTTTGGTTTTCGTTTGTTTTTGACAGTGGCCATCCTAACGCGTGTGA GGTGATATCTCATTAAGGCTTTGATTTGCATTTTCTAATAATTAGTGATGTTTTCATATG CTTCTTTTGATTTGTATATCACCTTTAGAGAAAGTCTATCAGAGTTTAAGCCTATTTTTG AAACTGTGTTGTTTCTCTGCTGTTGAGTTCTAAGAATTTTTTTAATATATTCTGGATATT AAAACTTTTTTCAGATGTATGGCTTGAAAATATTTTCTACCATTCTGTAGGATGACTTGT GTTTCTGTTAGTGATGTTTGAGCACAGGAATGAAGGAGGCTCAGATCTGACACTGACTGT GAGATTGAAGAGCACTCCAGACAGAGGGAAGAACAGGGTGAGGCTCAGGCACAGGAGGGA CCAGTGAGAGGATCCACAAGGACGTCTGTGTGATTAGACAGAGGGAAGCAAGGCCAAGAA CAGGAAATGACTTTGGAGAAGTTGAGCCTGTGTGTGAATCGTGTCTGGCTGCACAGGGCA CTGTGAGCATTTGGAGAGTTTTGTGCAAGAGACCATGATTAACTTTTATTTTCATGGGAT CCCTCTGGCTGTTGTGTGCAGAAGAGACTGTGTGTGGTAGAGGAAAGACAGAGCAGAGAA GATAGAGAGGAGGCTGGTGAACATCTCAGGCAGGAAGTGGTGCTGGCTGGAACCAAGATG GCAGTGGTGGTGGACATGGCTGTCTTATGGGTAAATTCTGAAGTTAGACTTATGAGAATT GCCAATAGATTGGGTGTACAATGTGAATGACAGAGAGGGAGCAAGAAGACTTCCAGATTT TTGCCCCAATCCATGGGTAGAATGGAGGGGTCAGTCATTGAGGCAGAAAAGATTGTGCAA AAAAAGAGATCTGGGGGAAAAAAGGAGGAGTTCAGATAGAATAGGTTGCATTTTGTGTGC CTTTCGACAAGATGTGTGGGTTTGAAGTATACTATTGGATCAAGGACTATAGTCAGCAGA GGGGAGAGGGCTGGGTGTAAATTTGGAAGTCGTCAGTTTATTGATGGCATGAAGACAACA CAGTGGATGAGATTGCAAAGCAAAAGTAAAGAAGAGCTCAGGGCTGCTCTGATATTTAGG GTCAGGGAGATGTGGAGCATCTAGCAAAAGGGCTGCCAAGAAGGTAAGATGGAGCCAGAA AGCACGATGTCCTGTAGTTAAGTCAAGAAGGGCTTCTGTGTAGGGAAGGTGAGCAGCTGG GTCCTCTGCTGCTGTGAAGTCCAAGAAGGAGAAGACTGCAAGACGGACATTTGGACTCAG CCAAGCAGTGGTCATGGTGACCTTGATAACAGCAGTGCTGAGATGTGGTGTGTGTGTGAA TGTTAATTTGAGTAATCAAGACAGAATGGGGGAGTGAAATCACAAACAGTTCCATGGAGC ATCTGCTGTGCAGGGGAGTAGCAGGGAAGTTCAGAGATGAAGGAGAAGCCTCCCAGGCAG CCTCTGTCACTCTCCACCGTGTGAGTCTATATTAGTTTCCTGTGGCTGCTGTGACAAATT GCCACACATTTCCTGGCTTCAAACAACAAACATGGATTAACTTAAAGTTCTGAAGGTCAC AAGCCCAAAATGGGTGTCACTGGGCTAAAATCAAGGCATTGGCAGGCAGGGCCAGTTCCT TCTGGAAGATCCAGGGGAGGATGCGCTTTCTCACCTTTTCCAGCTTCTAGAGGCACCTGC ATTCCTTGGCTCAGGACCCTCCCTCTGTCTGCAAGTCAAGCAGCCTGGCATCTTCCAATC TATCTATGCCCTCCTCCTTTCACTACTTGTAAGGACCCCTGTGATTCCACTGGGCCCACC CAAGTAATCCAGGATAATTTCCCCATCTCGATATCCTTAACCTAATTCCATCTGTAAAGC CCCTTTAGCCATGTAAGGTAACAGATCAACAGGTTCCAGGGGATTAGGGCATGGACATTT TGGAGGGGTCATTATTCTTCCTATAAGAGGGATATAATTTATTTTATTGACTTGTCTTCC CCACACCACCAAACTGTGAGCTTCTCAAGGGCAGGTGCCACGTCTGAATCAAGGCCCTGT AATTCTCTCTCACTTGCCCTCTTCCTACCCATCTTATCATAATTCACACATAGATATTCA TTTGTTTGGCAGTCATTTATTGCCACCTCCTTCAGTTAAAGAGTGAGATGCAGGGGGTCA GAGCCCATGCCTACCGTGTCCACCACAGTCCATCCAGCACCCAGCCCAGGAACTCACACA CAGGAGGCCTCAGCAGGACTCCAGGCTTTGGGGTCAGAAGGAACTGACTGGATTGGGTCC CGGTATAAGAGGGAGTTTGCGCAGGGTACTTAACCATTTCTACCTCAGTTTTCAAATTTA TAAAATGGAGACAATAATAATATCTTACTATGGAATTGTTGTTGGAAGTTAATGAGATTA GTAAACACCACATAAGGTGATAATTGAGTATTAGACATTAGAGGAACGTATTAAAGAGAT TTCAGCAAAGTGCACATGGGATGAATGGAGGAAGGAACTCCTGGGCCTCCTTCCTGGATG CTCTCTGGTGCATGCTGGCCCCACTGCTCTGCACTGACTCCCTTCTCTTCCTCCATTCAG GGACCCCTGATTGAATCCCCGGCAGATGACAGCCCCCCACACCATGCTCCGCCAGCCCTG GCCACCCCCTCCCCAGAGGAAGGAGAGATCCAGTATGCATCCCTCAGCTTCCACAAAGCG AGGCCTCAGTACCCACAGGAACAGGAGGCCATCGGCTATGAGTACTCCGAGATCAACATC CCCAAGTGAGAAACTGCAGAGACTCAGGCCTGTTTGAGGGCTCACGACCCCTGCAGCAAA GAAGCCCGAGACTGATTCCTTTAGAATTAACAGCCCTCCATGCTGTGCAACAGGACATCA GAACTTATTCCTCTTGTCAAACTGAAAATGCGTGCCTGATGACCAAACTCTCCCTTTCTC CATCCAATCGGTCCACACTCCCCGCCCCCGGCCTCTGGTACCCACCATTCTCTTCTCTAC TTCTCTGAGGTCGACTATTTTAGGTTCCAAATATAGTGAGATCGTAGAGTG OMIM ID 606094