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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SLC25A14 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9016
Official gene symbolSLC25A14
Full namesolute carrier family 25 (mitochondrial carrier, brain), member 14
Aliases,BMCP1,MGC149543,UCP5,
Gene summaryMitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is widely expressed in many tissues with the greatest abundance in brain and testis. The gene product has an N-terminal hydrophobic domain that is not present in other UCPs. Two splice variants have been found for this gene. [provided by RefSeq]
LocationChromosome: X   Locus: Xq24
Gene position129474047 - 129507335  Map Viewer
Gene orientationplus
Gene size33289 bp
Gene sequence
OMIM ID300242