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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CCNT1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID904
Official gene symbolCCNT1
Full namecyclin T1
Aliases,CCNT,CYCT1,HIVE1,
Gene summaryThe protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing this cyclin and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q11-q13.3
Gene position49110781 - 49086752  Map Viewer
Gene orientationminus
Gene size24030 bp
Gene sequence
OMIM ID143055