| Entrez gene ID | | 9069 |
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| Official gene symbol | | CLDN12 |
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| Full name | | claudin 12 |
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| Aliases | | ,-, |
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| Gene summary | | This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is expressed in the inner ear and bladder epithelium, and it is over-expressed in colorectal carcinomas. This protein and claudin 2 are critical for vitamin D-dependent Ca2+ absorption between enterocytes. Multiple alternatively spliced transcript variants encoding the same protien have been found. |
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| Location | | Chromosome: 7 Locus: 7q21 |
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| Gene position | | 90032712 - 90045268 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 12557 bp |
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| Gene sequence |
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