Entrez gene ID | | 9114 |
Official gene symbol | | ATP6V0D1 |
Full name | | ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1 |
Aliases | | ,ATP6D,ATP6DV,FLJ43534,P39,VATX,VMA6,VPATPD, |
Gene summary | | This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16q22.1 |
Gene position | | 67515089 - 67471917 Map Viewer |
Gene orientation | | minus |
Gene size | | 43173 bp |
Gene sequence |
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OMIM ID | | 607028 |
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