Entrez gene ID | | 91227 |
Official gene symbol | | GGTLC2 |
Full name | | gamma-glutamyltransferase light chain 2 |
Aliases | | ,GGTL4,MGC96916, |
Gene summary | | Gamma-glutamyltransferase-1 (GGT1; MIM 612346) is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. Autocatalytic cleavage of the GGT1 precursor polypeptide produces a heavy chain and a light chain that associate with each other to form the functional enzyme. Light chain-only GGTs, such as GGTLC2, contain a region corresponding to the GGT1 light chain, but they lack the membrane-anchoring heavy chain region (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM] |
Location | | Chromosome: 22 Locus: 22q11.22 |
Gene position | | 22988782 - 22990368 Map Viewer |
Gene orientation | | plus |
Gene size | | 1587 bp |
Gene sequence |
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OMIM ID | | 612339 |
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