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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CBFA2T2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9139
Official gene symbolCBFA2T2
Full namecore-binding factor, runt domain, alpha subunit 2; translocated to, 2
Aliases,DKFZp313F2116,EHT,MTGR1,ZMYND3,p85,
Gene summaryIn acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq]
LocationChromosome: 20   Locus: 20q11
Gene position32077928 - 32237837  Map Viewer
Gene orientationplus
Gene size159910 bp
Gene sequence
OMIM ID603672