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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PCSK7 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9159
Official gene symbolPCSK7
Full nameproprotein convertase subtilisin/kexin type 7
Aliases,FLJ23503,FLJ45329,LPC,PC7,PC8,SPC7,
Gene summaryThe protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q23-q24
Gene position117102811 - 117075788  Map Viewer
Gene orientationminus
Gene size27024 bp
Gene sequence
OMIM ID604872