Entrez gene ID | | 92 |
Official gene symbol | | ACVR2A |
Full name | | activin A receptor, type IIA |
Aliases | | ,ACTRII,ACVR2, |
Gene summary | | This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q22.3 |
Gene position | | 148602570 - 148688393 Map Viewer |
Gene orientation | | plus |
Gene size | | 85824 bp |
Gene sequence |
| |
OMIM ID | | 102581 |
|