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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STRADA (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID92335
Official gene symbolSTRADA
Full nameSTE20-related kinase adaptor alpha
Aliases,FLJ90524,LYK5,NY-BR-96,PMSE,STRAD,Stlk,
Gene summaryThe protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q23.3
Gene position61819330 - 61780192  Map Viewer
Gene orientationminus
Gene size39139 bp
Gene sequence
OMIM ID608626