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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ACVR2B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID93
Official gene symbolACVR2B
Full nameactivin A receptor, type IIB
Aliases,ACTRIIB,ActR-IIB,MGC116908,
Gene summaryActivins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]
LocationChromosome: 3   Locus: 3p22
Gene position38495790 - 38534633  Map Viewer
Gene orientationplus
Gene size38844 bp
Gene sequence
OMIM ID602730