Entrez gene ID | | 9340 |
Official gene symbol | | GLP2R |
Full name | | glucagon-like peptide 2 receptor |
Aliases | | ,-, |
Gene summary | | The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor ans GLP1 receptor. Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R). [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17p13.3 |
Gene position | | 9729381 - 9793022 Map Viewer |
Gene orientation | | plus |
Gene size | | 63642 bp |
Gene sequence |
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