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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TSIX (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9383
Official gene symbolTSIX
Full nameXIST antisense RNA (non-protein coding)
Aliases,NCRNA00013,XISTAS,
Gene summaryIn mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq]
LocationChromosome: X   Locus: Xq13.2
Gene position73012040 - 73049066  Map Viewer
Gene orientationplus
Gene size37027 bp
Gene sequence
OMIM ID300181