Entrez gene ID | | 9383 |
Official gene symbol | | TSIX |
Full name | | XIST antisense RNA (non-protein coding) |
Aliases | | ,NCRNA00013,XISTAS, |
Gene summary | | In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the 3' end of the XIST locus, and is coexpressed with XIST only from the inactive X chromosome. The mouse ortholog of this locus is required for imprinted X inactivation in extraembryonic tissues and silences Xist through modification of the chromatin structure in the Xist promoter region. In contrast, imprinted X inactivation does not occur in human extraembryonic tissues and transcripts from this locus do not repress XIST expression or affect random X chromosome inactivation in embryonic cells. This transcript is thought to be unspliced and extend over more than 30 kb, but its exact nature has not been determined. [provided by RefSeq] |
Location | | Chromosome: X Locus: Xq13.2 |
Gene position | | 73012040 - 73049066 Map Viewer |
Gene orientation | | plus |
Gene size | | 37027 bp |
Gene sequence |
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OMIM ID | | 300181 |
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