Entrez gene ID | | 9429 |
Official gene symbol | | ABCG2 |
Full name | | ATP-binding cassette, sub-family G (WHITE), member 2 |
Aliases | | ,ABC15,ABCP,BCRP,BCRP1,BMDP,CD338,CDw338,EST157481,MGC102821,MRX,MXR,MXR1, |
Gene summary | | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. [provided by RefSeq] |
Location | | Chromosome: 4 Locus: 4q22 |
Gene position | | 89080011 - 89011416 Map Viewer |
Gene orientation | | minus |
Gene size | | 68596 bp |
Gene sequence |
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OMIM ID | | 603756 |
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