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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFRSF8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID943
Official gene symbolTNFRSF8
Full nametumor necrosis factor receptor superfamily, member 8
Aliases,CD30,D1S166E,Ki-1,
Gene summaryThe protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq]
LocationChromosome: 1   Locus: 1p36
Gene position12123434 - 12204264  Map Viewer
Gene orientationplus
Gene size80831 bp
Gene sequence
OMIM ID153243