Entrez gene ID | | 943 |
Official gene symbol | | TNFRSF8 |
Full name | | tumor necrosis factor receptor superfamily, member 8 |
Aliases | | ,CD30,D1S166E,Ki-1, |
Gene summary | | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36 |
Gene position | | 12123434 - 12204264 Map Viewer |
Gene orientation | | plus |
Gene size | | 80831 bp |
Gene sequence |
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OMIM ID | | 153243 |
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