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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFSF8 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID944
Official gene symbolTNFSF8
Full nametumor necrosis factor (ligand) superfamily, member 8
Aliases,CD153,CD30L,CD30LG,MGC138144,
Gene summaryThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q33
Gene position117692770 - 117665124  Map Viewer
Gene orientationminus
Gene size27647 bp
Gene sequence
OMIM ID603875