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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAP4K4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9448
Official gene symbolMAP4K4
Full namemitogen-activated protein kinase kinase kinase kinase 4
Aliases,FLH21957,FLJ10410,FLJ20373,FLJ90111,HGK,KIAA0687,NIK,
Gene summaryThe protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q11.2-q12
Gene position102314488 - 102511152  Map Viewer
Gene orientationplus
Gene size196665 bp
Gene sequence
OMIM ID604666