Entrez gene ID | | 9448 |
Official gene symbol | | MAP4K4 |
Full name | | mitogen-activated protein kinase kinase kinase kinase 4 |
Aliases | | ,FLH21957,FLJ10410,FLJ20373,FLJ90111,HGK,KIAA0687,NIK, |
Gene summary | | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q11.2-q12 |
Gene position | | 102314488 - 102511152 Map Viewer |
Gene orientation | | plus |
Gene size | | 196665 bp |
Gene sequence |
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OMIM ID | | 604666 |
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