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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for MAPK8IP1 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 9479 Official gene symbol MAPK8IP1 Full name mitogen-activated protein kinase 8 interacting protein 1 Aliases ,IB1,JIP-1,JIP1,PRKM8IP, Gene summary The protein encoded by this gene is a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8). This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes. [provided by RefSeq] Location Chromosome: 11   Locus: 11p12-p11.2 Gene position 45907202 - 45928016  Map Viewer Gene orientation plus Gene size 20815 bp Gene sequence >MAPK8IP1:45847202..45868016:Length=20815 AGTCCCGCGGGCCGTGCGCGGTGCTGTGCCGCGCCCTGCCAGACACAGGTGCGCCCGCCT AGCCCGAACTCCGCGGCGGCGGCTGCCCTCTCGCCGCGCCTCCGCCTCCTTCGCAGCCGC CGCCTCCTCCGCGCCGCGCTCCGCCCGGATGGCCAGGGCTGTGCCCGAGAATGGCGGAGC GAGAAAGCGGCGGCCTGGGAGGGGGGGCCGCGTCCCCGCCCGCCGCCTCCCCGTTCCTGG GGCTGCACATCGCTTCGCCTCCCAATTTCAGGTGAGAGTCCCCGGCCGCCGCGCGCCTCG CCCTTCAGCGGGGACTGATCCGCATTGGCTGCCCTGCCCGCCCCCCACCCCAGAACCTCG GGAACCCGGGAACGAAAGGGCTGCGTGGGAGTGGGGTCTCTTCCCGGGACAGAGCCCCCC TCAGAAGCCCCGCCAGCCTCAAGTCCGGACTGGTAGCCGTTGCATGTTCACGAGGCTGTT CCCTCCGCCATTCCTGGTCCTAGGCTGGGAGGTCTGCGCTGGAATTGGAGGAGGGGGCTC GGAGGCCTCCTTCTCCCCAACCTCCGGGCTGCGGCAGGGTCTGGGGTCGGGGTTGCGATC CCGGAGCGGGCAGGCAGGCTGCATCTTAGCCTGTGAATAGAGCTGGGAACAGCCTGGAGG GGCGCGGGTCGCAGTTTCCTGGGGCAACGACATTGTTGGTGCTGGGAGGAGGATGTTTGA GCCCCTCCCCGAGCCCTGCCTGGCCAGATGGGCCTACCTGCCAGGCCTGGCGTGGCCGGG CCCCTCTCTGGATTGGGCAGCACCGACCTAGGCAGGTGTGTCTCTCAGGGCAGGCGCTGA AGGCTCAGCCTCAACCAGGGGAATCCTAGGCCCGGCTGCGGGAAGGGAAGTCGGCTCGGC TCTGGAGTAGCCAGGGCCAGCGAGGGTGTCGAGGGGATCCCTGCTGGGGTAAATACCCAG AACCCTGACCTGAGCTCCTATTCCACCACCCCCACCCCCCAATCTGGTGTTAGGCCCGAT GCATTTCAGAGAAGTGAGGGGTGAGTGTTGTGTGGAGGAGGAATAGATGTACCTCCCCCA TAATTCTGAACCCTAGTTGGTGGGGAGGAAGAGGCCGAAGTCACTGCTCCCGGCCTAGAG AGGGAGGCTTAGACATACCCCATTGTTTCCCCATCTCGAGAACTGGCGCCTTCCCCTCTC CTGGGGCACCACCCCAGCCAGGCTCCAGCTGGGCTGTGGTGCCAGCCCCTCCTGGGAGCA AGGGGTCACTGGCTCCCAGGTCCTCAGGTGGGCAGAGACCCCTGGGGATCTCTAATAGCA TCATCAAACTCAGAAACCTTCCCTGAGGCCCTGAGCTGAGCTGGAAGGACCAGAGGGGGC CAGATGGAGGAGGCCAGGCCTGAAGGCTCCAGGGCTGCAGCTCTCTGATAATGCCTTAGA CTGAGGTCTGAGACTCCACCTGGCATGGTGCATGAGGCCTCCATGCAAATACTGCCTCCC CACCTGGAGGCCTCTGCAGTGGAAGCACATGGGGCTTAGAGGGACCTGGGTTCAAATCCT AGCTCCACTACTTTCTAACTGCATGACCCAGGCAGGTTTTTGTCCTCTCTGGGTGCCATC TGTTAAGTGGGCTAATTAATATTGATTCTTGCCTGGAAAGGAGAAAAAGCACATCAGGTC AGTGTTCAACAAGTGTCAGCCCCCACACTAGCAGACAACACTACGGCTCGCTGCTGTCCA GAGTGTCTTCCCAAGGCCCCTCCTTTAACCCTCATAACTGCCCCAAGAGAGGGTAGTGAC CTGCCCATTTTATAGATGAGGTGATTGAGATTAACAAAGGCAGGGTGGCTCATCTGGAGA CTACAAAAGAGTCAGAGACTAAGGCTACACTGGGACCCAGGTCTGTGCGTGTTTAGTCCA CTCTACGTCCCAGCCCTGCCTCTGGCCCAGTGGGCAGCTTTTCTTCCTCGACCTGCTTCC CCAGGTGTCATAGATGCTTTAATGAGAGGAGCTGAGGAAGCAGACACCAGCCAGTGAATG TGTGGCCAGCTCTGCGGCATGTGGGACAAGGGTGGCAGTAGGCCACGAGGCTGAGGTGTG GGCCAGCACTCCAGAACATGGTGGCCTGGCTGCGGAGACAAGGCCAGTGCGTGGGAATAA TAAGCGTCAGTGTCTCAGGCCCTGCCGGCCTGCCCCGCTGCTCCCAAAGCCCCCGCTGCC CTTTCTCCTGGCCCGCCTCTCACTGTGCTTGGCCAGGCTCCACTTAACCCTGGGTGGGTA GATAGTGCTTTCTTGTGGCTCTTTGGTGGAGTCATAGATCCAACTGGCCTGGGTTTGAAT CCTGGCTGGCCCTTCTTACCTGTGTGCCCTGACACTGGGCACTTAAGCCCTCTGAGCCTC TGAGATGCCAGCACTGGCCCCTGCTCAGGATGGTCCTAAGAATCAGATGAGATAACACGT GTTGAGTGTTTCAAGGGCTGAGGAGAGCCGCCTGTAGGCAGGGCTGTGTGTGTGCACACA CACACAGGCGCCTTGACCCCCAGTGCCACTGTCAGCTCCCAGAAAATAAAGGGGGTCTGT ACCCAAACTTTGGTATCCCCATTGCTCAGCACGGGATAGTTACTCAATAACAGTGGTAAG CGCTGACATTTGGAAGGCACTCAGTTCGCCCAGGCACCATTCTAAGAGTTTCCTATGTGC AAGAGTATTTACTCCTCCCAATAACTGTATCAACAGAGCGTTGTTATTATCCACACTTGC ATGAAGAAACTGAGGCAGAGGGAGGTTAGGTAAGTGGCAGAGCTTGTAAGTGGCAGGCAG TCTGATGTCAGAGCCACCCCAAAAAGAAAGAGCCCTAGAGTATTGGAAGAGCATGTGCGG AGGGGGCGAGCATGTGGACCTGACCTGAAGGGGTGGGAGCATTCGTTTGTTTGTGGTAGG TTAAATACGTGTTAATTTTTGTTCTGATTATAGCTCCAGCTGTTTATAGTGGTTGGTTAC CTTTGGGTATGGTATGGGGTGAGGGATTTTTACTTCTTATTTTACATACTTTTTTTTTTT GAGACAGAGTCTCACTCTGTCGCCCAGGCTGGAGGTTGGAGTGCAGTGGCATGATCTAAG CTCACTGCAACCTCTGTATTCTGGGTTCAAGCGGTTCTCCTGCCTCAGCTTCCCAAGTAG CTGGGATTACAGGTGCCCACCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGG GGTTTCAACATGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGGTGATCCACCCATCT CAGCCTCCCAAAGTGCTGGAATTACAGGCTCGAGCCACCACGCCCAGTGTCATACTTTTA TATTACAGGTTGAGTATGCCTGATCTGACATGCTTTGGACCAGAAGTGTTTCAGATTTCT AATTTTTTTGGATTTTGGAATATTTGCATATGCATAACGAAATAGCTTGGGGATGGGAAC CCAAGTCTAAAAATGAAATTGATTTTTTCTTATATATCTTATACATATAGCCTCAAGGTA ATTTTATACAATAATTTAAATAATTGTGTGCATGAAACAAAGTTTTGATTACAACCTGTC ATGTGGAGTCAGGTGTGGAATTTACAGCCTGTGCTGTTATGTTGGTGCTCAAACATTTAG GATTTTGGAGCATTTCAGATTTCAGGTTTTTGGATTAGGGCTGCTCACCTGTATTTGACT TCTTATTTTATAATGAGTATAGGTTACTTCTGTGTCTTACAAAATAATAAAAGAAAATTC AAAATTAAAGTGATACATGTTCATTATAAAGAAAACTCTAGAAAAGAGAATTTAGAAATT TACACAGTGGAGACATTGGCACTGGGTAGGTGGGACAAAGAGGAGGGGCAGAAGGACAGT TCACGTGGGAGGAACAGCAGAGACAAAGGGGGTTTCATGGACAAGAAGGGAGCGAGCGGC CTGTCTGGGGTGTGTAGAAGGGGAATCGTGGATCTGAGAGACCTTAGAGACCAGCTCGTC CAACCAGCTCCCTCCCCTTATGAGGAAACAAGAGAGGGCGAGTGGCTCCCCCAAGAGCAC ACAGCAAATTAGTGGCAAAGCTGGGATAGAGCCAGGCCATGGCTGCCTGGATGGTTGCCA TCTGCCCCAGCACCCTGCCTCAGGGATGAGAGATGGGGCCACCGAGAGGCTTCTTCCTTC ATTCACTCAACAAACGTTTGCACTTTGCCTAGGTCACCAGGGAAACACTGCAAAGGCCCA GACGTGGGCCTGGCCATCATGCTATTGGTGTTGTAGAGGGGAGACAGACAGACAGACGGC TTTACAGATGGGCTGGTCGGTGTGATGATGGCTCAGGTCAAGGGACCCAGGCTCAGCGGG TCTAGACAGGCCCCCCAGAGGCAGGGACATTTCAGCTTAGGCCTGGTGGACGCATAAAAA TATCACCCAAGGGTGTCACTGGAGTGAAGGGCGGAGACCAGAGCGGGTGGGCAGGGTGTC TGGTGCCCAGTCTGGCAGGAGGGTGGAGAGCAGGATGTGCAGGAACTTGTAGGCCATGTG ACGATGCCGACCTCTTCACCAACAGCCAGAGGAGCTGGCAGGGGGTTAGGAAAGGAATGA CAGGGTCAGACAGATCCTCTAGGACAGGGGTGTCCAATCTTTTGGCTTCCCTGGGCCACA TGGAAGAAAAATTATCTTGGGCCACACGTAAAATACACTAACACTAACGATAGCTGATGA GCTAAAACACAAAAACATCTCATAATGTTTCAAAAAAGTTTATGAATTTGTGTTGGGCCA CATTCAGAGCCATCCTGGGGCTCACGCACCCATGGGCCATGGGTTAGACAAGCTTGTTCT AGGAGGATCACCTGGCTGCTGGGTAGAGAGCGGCCAGGGGACTAGCCATCCTGCTGGTAA GAAGGAGGGACAGGTTCAGGGTGTGAGGAAGAGTTAGGGGGCAGATTAGCCTGCTTGGTG AGGGATACAGAATAGGGAGTGGGGAGGCAGGAGTCTAGGATGATGCTGGGGCTCCTTGGT GGGTGGGGTGTCCAGTGGGAGACCAGAGGGCGGTGGGCAGGGTGTGAAAATCATGTGGGA ACCTGCTGAATTTGAGACTGGGGATCATTGGAGGACCCAATTGGAGGAATCATACAGTCA GTCGGTTTTGGGTCTGGAGCTCAGAGGAGAGGATAGGGCTGGGGCCAAAGACCCTGGGAG TCTGAGTTTGGAGGGATGGCCACTGAAGCCTCAGAGAGGACATCACTGTCCAGGGAGACT GAGCAGAGGGCAGGAAGATGGCTGGCCGGTGGCCTGTTCAGCCAACCATGTTTCGGTGGA GGTGGGGAGGTGCTGCTGGAGCTGCCTCATGCCCAGGACCGCCTTGGCCTGGCTCCTGAT GGACCTTGGATGTGGAGGCAGAGAGTGTTGACTTGCCTCACACAGTCCGGCAGTGGCCAG GGCAGAATTTCAACCCCAGCTCGCTGATGGCAGAGCTTTAAAGTTCGTCTCTGGATTGCT GGAAATGGGCCACAACACACTTCTAGCTTGGGGCCCCCATGGTTCCCACAAATTGGGTCA CAGCCACCATCCACACGTAGTTCTTAATCATTCTATGATGCCATCTTTGTTCCCTGGCCC CACTCTTGTATTCATTCCAAAATAGCAGGAGCGTCTCTGGGTGCTTTGCCTTGTTCCGCC ACTGGAGATGCCAGTGGAGAGCTCATGGCTCCTGCTGTCATGTTGCTTGCAGTGCCTCTT TAATAGGCACTGATTTAGCACCTATGGTGTGCAGGGTTTTGGGCTTTGTGCATAGATTGG AGCAAAGGTGGGGAGTCAGTGCCCAGGTGAGTATGATGACCCTGCCCTCAGGAAACTTGC AGCTCTGGGGAGGGCAGGCAGCCCAGCAGCAGACGGGGAGCCCATGCTAGGCTGGCATGA CCCAAGATGAAAGTCTGTGAAGGACAGCAAAGGAGAAAAGAGCGCCCCAGATTCTACCCC ATCTCACAACTCTGTGTCCATGTGAGTGTTTCTTCCTGTGTGCAATATCATCCTGGGGAG ACCACTGGATCATATATGCTGTCTTTTTGCTCATTTTATTAGTTGTCACCTTAATACACA GACTTTATAATGTTGATTCCAAAAGACTGCATCACATTTCATCTGCTGATGGCCACGATG GAACCAGCCCCCTGGTGCTGGGTGACGCAGGTGTTTTCAGTTGTTTGCTGTGATGAGGAA TGAACATCCTGTGTGTAACAGTTCTTCTCCAAACAATGTGGGATTGTTTCCTCGAAGCAG TTTCCCAAAAGTCGAACAACTGGATCCCAGAGTTCTTGCAATGTATCAGCATGAAGATGT TTAAACAGATCAAACATGTTATAACCGCAAGTGGGGTTGTCCCTCGGGGCTCATTTCTTT GGTTGGATTCAGTTTTCGTTGGAGATGACCTCCGTATGGAGGTGGTCAGGAAGGGAATTC TGACCCAAAGAACAAACCCAGCCCAACCCCATGTTCACCCAGAGCCAGGTGGTGGGGGTA GAGCGAGGGCCTGAGAGGGATGCTGGGTCTGGCTCATCCCCACCCCACCGTTTCAGCCAG CACCGTCTTCCCAGAGGACCTGACATCCTAGCCCAGACTCTGGTGTAGGTGGGGACACAG GAAGTTGATTGGAAAAGTGGACTAACTTAGAGATTTCCAAGGCAAAAATCCAGAGAGCCC TGGGACACCTGTGGTTAATTCATTCAGCATTTGTCAAGTACCTATTAGGCACCACACATG TTGATCAAAACAGATATGATCCCACCCATATGGATTAACTGACTCCAAGGGGAGGCCACC GCGGGCCGCATAACCCAAAGGTAAAATTACAGTGATACGGAACCACAGCCAGGAGGGACT CCGAGAGCCCATAGCAGGGCGGTTTGGCTTGGTCCCAGAGGTCAGAGAAGGCTTGCAGAG GAGACCATGCTACTGCTTTGGGAGCTGCGCTATTGAAGGAGGAGATAAAGGTGGGAGGTG GGGGGAATGAAGGGAAATGATACTGGTTGGAGGGAAAGGAGGCTTTACAGAGCCTTCAGG CCACAGATGAGAATTTGGGCCCCTTCTCCTAAGGACCAGGGGAAGCTATTAAAGGGCTTT GAGCTGGGAAGAGTGACCAGACCAGATTTGTAATTCAGAGGTCAGCTTTGCTGTCATTAC CTGGTGGAGAGTGGCTGGTAGAGGAACCAGAGGGAAATGGGGAACCCACTTAGGGTTGAG CGGCCAGTCAACAGGTGTCCTGAGAACTCACTGGGAGCCAGCTTCGTTCTCAGCACTTAG AGGGCTGCAAAGAGGCAGGCTGGATCCCTGGACCACACGTGCCCTCTGTCACAAGAGAGG CTTGTGGGGCATTGTGGCCAGGACCCAAGGTCAATCAGCTGGCATCCTTACCTCCTCACC ACAGCACAGCCAGGAACACAAAGGCCCAAGAATGACATCTGAACAGCCAATGCCTGGCTC AGATTTGGCCTTGCTCAGCTAAAGCCTCAGCACTTTACCACTTAACCTTTGCTTTACATA CACTTCTAACTCAGCCTACTACGGAGCTGAAATAGTCCGTTAGAAAGGGCAGGACTGTGG TTGGTGGAAATGTGACCCAGCAAGGCAGGGGAAAAGGGCCTGAAATCAACATCAGAACAC AAAAGGCATGTTTGTTCAGGGCCATTTAGAAAAGTGCAGCTCAGGGTGGGGTGGGAGCAG GAGCTGGTATGGCGAGAACAGTGAGGAGCTGGCAGGGCAAAAGCAAGGACTGGGGCAGCA GAGTAGGAGGGATCAGGTGAATGCAGGAACAGGGCCTCAGGTAGAAAGGTCAGGGCGGTC TCCAGAGACCAAACTCACAGCTCAGAGCCACCAAACGTTAATATGGATGACGTCTCAAGG ATCACAGCATCCAGGATAGACAAGCAGGTCTGATGGGTGGGCAGGGGCTGCTTCTACAGG AGACTGCTGAAACTTCCAGACCCAGAGGTGAGGGAGGCCGGCCTGCGGAGGGCCGTAGGA TTCAGTTTGGAGGCCTCCTGGTGCTAAGGCTGCCATGAGCAGGGTGGATCAGGCGGGACA GGAGGGAACCGCCCTCTTTTCCCCTTCTTCCCCTCCCTTCTCCCCTCCATCTTTTCCTCC CTCCTCCTTTCCCTCCCTTCCCCACATTGACCTTCCATGAGCCTTCAGGGACCAAGTGTC TGTTTAGCCTTCTCTCCATAAAGGGACCCCCCAGGGTTTTAGCTGGGAGGCCAGAACATC TGGTGCCTGGAAAAGAGGAAAGGGCAGAGTCTTGGATGGGGGGTGACTTGCACAGGGTAC TCTTTGACCAATCAGTCCCCCTTGATCCTTGGTAGTGACCTCCTACTCACACAAATTCCA TTCTGCTAACCCTCACCAGCCCTCTGAGGTGGGTGGGCAGGGATTGGTGGCTTCATCCTG TATCTGGGAAGCTGAAGCATAAGGCACCTTTATGTCTAAGCCTTAGTGTTCCTCATCTGT AAAATGGGAAAAATGGAACAAACCCTCTCCCAAGGTTGTTGCAATGAGGATTAAGAGAGA TGCATGGCATAAATGTTGGGGCCAAGATGGGGCAGCTTCAACGTGAAAGAGTCAGGATTT ATTTCAGGCCTCCTGCTTCCAAGCCTGATATGGTGATCATTCTTCCATCCTGCCTTACTT ATGAGAGGCACCTAAAAAGTCAGACAAAGCATCCCCCTTAACCCACCCCAGTAGAGCCAG GGATCAGGCATAGGCTCTCTGACCCCCAGCCCAGTATTCTTTCTAGCATTGCCCAATTAA AGCCCAGTGCCCTCAGCTGTACAGGAAGAATGCTGCTGTCCTTGCCCCACCCAGACCTAT TGTCCAAGGAAGTGGGAATATCAGGTGATGTTGAGGGTGTAGAAGTGAACTGAGAAGCCT CTAACCCAGGTCTAAGCCAGACCCTGCAGGCCCTGCTCCAGCCTGCAGTTCGAGAGGAGC AGGTGGAGGCAGAGGCTGTCCTGTGACAGACATCTAGCAGGCTCATGCTGAGGACTCAGT GTATGCAGGATGAACTCGCCAGCTCTGCCCTCCAGGAGCAAGGGGAGGAAGGGGTCTTGA TCACCTGCTGGGTACAGTATAGGGTCATCAATCAGGGTGCTGGATACAGGCCCCATCCAC CTTTGGAGCAGCCAGGGGGTGGGAAGTGGGTGTTTCTGAGGGAGGGCTGGCCCTGTCTGC TGCACACACTACTGTACATCCAGGCAGATGGTGACATCAGCCACATGCAAGGGCTGGGAG GGCTTCCTGGAAGAATGAGCTTAACTGAGCACTCTTCCAGCAAGCATGGTTTGAGAGTCT GCCACGTGCTCCCTCTGAGCACTGGGTTTGGCACTGGGGAGACACAGTGCCCACGCAGAC TACGCATGGAGCTGGAGGCCTTGCCTGCAGGCACAGGAACCTGCTGCTAGTGGAGAGCCT TGAGGGTTCCAAGTGGGGCGGGAGGGATGATGGCATTTCTGGCAGTTTTGCCTGATAGTG GCAGGTGGAGTGGGATGGTGCAGGCATAGGGAGACTGAGACAGACAGGCCAGTGGGGACA TCTGGGAGGGCAGAGGCAGGAGCTGGACTAGGGCTTGGCAGTGAGGAAGCGGAGCCATGT GTGAGGAGACACAGATGTGTGCAGGGGGGCTGGGCACCATGGCTCACGCCTGCAATCCCA GCACTTTGAGAAGCCGAGGCGAGCAGATCACCTGAGGTCAGGAGTTCAAGACTAGCCTGG CCAACATGGTGAAACCCTGTCTCTACTAAAAATACAAAAATTAACCAGGTATGGTGATGC ACACCTGCAATCCCAGCTACTCAAGAGGCTGAGGCAGGAGAATCACTTGAACCCAGGTGG CAGAGGCTGCGGTGAGCCAAGATCATGTCATTGCTCTCCAGCCTGGGTGACAGAGCGAAA GGCCGTCTCAAAAAAAAAAAAAAATATATATATATATATATATATATATATGTGCAGAGG TCACTGGCAGAGCAGGGGCATTTCAGGGCACCTCTGGGTCAGCGGTCCTGCAGCTCTCCC ATGCCATCTGAGTACCAGGGGCTCCCTTTTGCACCACTGGCCTTCTCGGTGACCATCTGG GCAACCAGTGTGAATTGAACACTTACTTGGTGCTGGCCACTGGGTTTTTGTCCCTGAGCC TGAGATGCCACCCTGCCCTGGCCGGACGGAGGAGGGCTGCTCTGGCTTCTGGGCCAGGCC CTCCTCCCCACTTCCACCCCAGCTGGCCAGCCACACCCTCCCCATGGCCTGGGGAACCAC CACCCTTGGGCTGCAGGTCAGACGTGACCCTACAGGGCACCTTGTCCATCCAGCCCCCAT TCCCCACCCCTCTGTGCAGTGCCCTCCAGGGGCCTCCAGGTTCTGTTTATGTCATTCCAA AGGGAGAGGAAGCTCATTACCACACAGCAGCCCTTCCAGCTCTGCTCTAAGGGCCCAAAC ACTGGCCTGCCCTTAGCTGTGGCTCTGGTGCCTCCTGCTTCCATAGGCCCTGCCTTCCTG GGTCCTGAAGGCTCAAGCTCTGGCTGCAGAAGGAGGCAGCCCAGATCAAACCCAGTTTGG ATGCAGCCTGGGCCCACAGAAGCCTCTCTGATGAGGTCGGGGGGCTGAGCCTATGGCAGT GCAAACCGAGTGTTCATTCTTAGGGTGTTTGGGAAGCCCCCCTTCATCTCCCACCTGGCA CCCTGACTGGGGAACTGGCCCTTTAAAGCCAACCAAGGGCTGGCTTTTGGGGGGAAACAT CCTAGATTTCTGCCATCTACTTACAAGCCTGGGCCAGGGAGGGGGGGCCACTCAGCCCCC GACAGGGGCATTGGAAGGGCAGGTGGAGCCAGTGGCATTGATTGCAGTAACCTGATCCCG TGAGGGAGGCGGCCACAGCGGCAGCAGCGCAAGGGCCAGGCCAGCCGGGAGGAAGGTGCC TGCAGCTGAGGGCTGCGCTGGGAAGAGCTGGGGCTGGGACCCGGGTCGGCAGCTGCAGCC TCCTCTCCTGGCCTGTCTATTTTTAATGAGCTCCCCAGGCTTCTGCAGCAGGCAGGACGC AGAAAGACAGGCCCAAGCGGTGGAGGCCAGAGGCCCCCAGCCCTGCCTTGAGCCCTGGCC CCCCCACCCTTCCGGGCATGAGAGGGCAGCCCTGGGGCCCCGCAGCCCCCCGGCCGGGCA GGGCTCTCCATGCAGCTGGTGCTGAAGATGGATTCGAGCCCAGACAATGACAGCTGGTTG GAGGATCAATGGGAGCGCTGGTAGGGGCTACCGGGGCTGGCGGGGGTGGAGACCGAGTTG GGGTGAGCTCCATCGAGCTCAGGGTCTCTGATCTGAATGAGGCGAGTGGCAGGGAGTCTG GGCCTCCTAGGTTCCCCTGGGGGCTAAGCCACCATCTCTCCTGGGTGACCTTGAACTAGT GGGTTTCCCTTGCTCTGTGCCTCAATTTCTTGGACTTATTTGGGAAAAGGCTCATACATT CTCCCCAACTTCCTAAATGTTCTACCCCCCCACCACCCCCCCAGCAAGCCAGGCAGAGTG CCCAGGACCTAGAGGTGAGCAAGAGACAGGCTGCCTTGCAGTGGCTGGCCCAGCCCTGCA TTCTGAGGTGGGGACTCAGGGCTGGCCTAGGGAGAGGGGGGTTCTAGTGGAGCTGGTTAG TATTCTGGTGCCCTGGTGCTCTGAGCTGTCTCCCAAGGTTGTAACACCTCTGGTCCCACC TGGGGCTTCTCCTGACCCCATCTGTGCAGCCTCCTGTTCAGGGTCCTTACACTGGATAAG GAGAAGATGTTGTGGTTGAAGAGATGAGACCACCAAGTGCACAGCATGAGGCTGGAGTCC TTTCTGGAATAGGCTGAAACTACCCACACTGACACCAGATTTTCCTTCGCTTGTTCCCTG GGCTCAAGGGGCATGAGTCTTCCTGAGCTGGGGCGTGGGGCACTCCTCTGAGGCTGCTGC CGGCGCCTCGGGTCTTGCTACTGCAGGGATTGCACTGGGAGCTCCCCTACTCCAGGCTGC TCTTCTCAAGTCCACATTCTCCATGGTGAACTGGCCTTGGCACCTGCCTTGACCCTGGGA GGAGGCTCTGACCAGTTGGGCCTTCTAAGCACTGCCTGCTGGTTGGCAACAGAATGACAG CTTCCAGGGAGGAGCCAGAGTGACCTGGAGCCTCCTCTTCCACTGCCACCCTAGGAGGAC TGCCTTTTGGCACAAGCCCCTCGCTCTTTCCCTGCCTGCTGACCACCCCCTGCATTGATA CAGATGAACCCCAAATCCTGTCCTCTGGGGGCTGTGTTTGGCCTTCAAGAGGCTGCACCC TGGAAGAGGTAACAGGGAGATGTGAGCAGGCATAGTGCCCCTGAGTTGTAACTTTGGCTT CCTGTCCCCACCAGGCTCACCCATGACATCAGCCTGGAGGAGTTTGAGGATGAAGACCTC TCGGAGATCACTGATGAGTGTGGCATCAGCTTACAGTGCAAAGACACCCTGTCCTTACGG GTAAGGGCAAGCTCCCAGGAGCTCCTGAGTGGGGTGGCAGGAAGGCTAGGGACAGGGGTA AGGGTATCCCCATAGTGACAAAGGGGGTTTCAGGTCTGTGCTGGCACCCTCATGAAATGA AATGATGTGCAAGAAACATAGGTATACTGCTTGGCACGTCTTGAGTGTACAATCAGAATT TCATTTGGTATTATTATTATTATTACTGCTGTCGGGGACTAAGACAGGAAGTAGCTCCTT CAACTGCCCACGAGATGGGAGAGGCCAGGAAGTCTTGAGACCTAGGGCAGTAACAATTAG GACCAGACTTAAGGGAGACTCAGGGCTACCCCTGAATCCTTTTGGGAGCAGCCCTGGCAG AGGGCCTGAGGCAGACAGGGTGGAGTCTGGTGGAATCTGCAGTGCTTTAGGGCAGGAAGA AACAGCCAAGGCACCCCTGGAATAGCTCCTGTGGCTGCTGGCTGCTATTACACCAGACAG ATGGCACCACGCGGCCTCCCAGACCCTCTCTGGCCTATAGTCCTAAAGGCCCCCACTGAG GGGTTTGCCCAGCATTGCTGCTGGTTTGGGCCCCTTGGCTTTGTCATAGGGAAGATGGCT CTCTCCTGTCCCTAAAGATCTGAATGCTGCCAGGAGGTCCCCAGCACCTGGGTAACTGGG GTCAGATGGGGATCCCAACTATGTCTTTTCAGAACAGGAAGAAGGGGCCGGCTTGCCAGG AAATGGAGGACAGAGCACAGGGCTAGGTTTTAGAGCCCAGAGCTCCTCTGAGCCCCCAAG AGGGCGGGTAGCCAGATACGGTGTCAGGAGAGTGGTTACCATAGGAGCGTGAGGTGTGCC TTGGGGAGGGAGTACCTGTCTCTGTGTTGACCTCCTGCTACTCCCAGAGACTCAGTAAGC TCTGCAAGAGGAAACCAAGGGGTGAGGATAATCCCCTAGTCCCCAGTACCCCAACCTTCC ACTCTCTGGCCAGGCCAGGAAGAGGCAGAGGCCTCTAGATTTGGGGAATGGTCTCAGAGC CCTGACTTAGCTTCTCAGAGGTCAGGCACCTGTTCTGGACTCTCACCCTGCCCTCTCCCC CAGCTGCACCAGCAGAGCCTTGGAGAGGGTTGCCTCCGAGCTAGGCAGGGGCCCCAGGCA CTACTGGCCAGAGGTGTGCCCCTAAGGGGCCTCAGACAAGCTCCAGCGGGCTTCACACAC GTTCCAGTGAATACTCAGCTCTCTCAGAGGCTGGGAGGCAGTAGTGTTATCCCCACTCAA CTGATGAGGGGGCCTGAAGGATCAGGGGATCTGTCCAAGGTGCCAGGGAGTTGGCGGCAG AACTGGAGCTAGATGGGGCTCTGCATCCTCAAGGCAGGCTCGTGGAGGACCGATCTAGGG CTGGAGGGGCCCCGGGCCAGCTGGCTTAGGGCGCGGCTGCCACCGCCTTGGTTCCTGGCC CCCGCTCGCCCCTCCCCCTCGGCGTCTCCTTCCCATCCCTCTCAGGTCTCCGCCGTTCCT TGCTTGGCTGAGCCTCAGTTTTTCCAGTTTTCCTCAAGACCCCTTCAAATACTATTTCCC CAACCCCCATCCCTTGCCCACCCCACCCCGAACTCCTTGGCGACCACTGAGTCCCCATAG CAACAGCGGTGACTTCACTCTGGGCTCGGCTTACAACCCCGGTGAGGTCACCGGCCGTTG CCAGGGGAACGGGAGGGCGCAAGGAGTCCGGGGTGGGGACTGTGGGGAGGTGCTGGCCGT CAGAGGCACGGCTGGATCGGGGAGGCGGCGGCCTCGCGCTTCCTCGCGGCGGACGGGCGA GAGCGCCCCAGTCTCCGGCGGCCCCTGCTCGGCTCCCCTCGTGCCCCCTTCGCGCCACAG AATGGACTCGCCCGGGCGGGGGGCGGTGCAAGCGGCCTCGGCCCCGCCCCGGCCCCGCCC CCTGACGCCCCTCCGTGCGCTGTGCAGCCCCCGCGCGCCGGGCTGCTCTCTGCGGGCGGC GGCGGCGCGGGGAGCCGGTTGCAGGCCGAGATGCTGCAGATGGACCTGATCGACGCGACG GGGGACACTCCCGGGGCCGAGGACGACGAGGAGGACGACGACGAGGAGCGCGCGGCCCGG CGGCCGGGAGCGGGGCCGCCCAAGGCCGAGTCCGGCCAGGAGCCGGCGTCCCGCGGCCAG GGCCAGAGCCAAGGCCAGAGCCAGGGCCCGGGCAGCGGGGACACGTACCGGCCCAAGCGG CCCACCACGCTCAACCTCTTTCCGCAGGTGCCGCGGTCTCAGGTGAGGCGCCAACGTGGG GGGCGGCGCCCTGGGCCGCCGCGGAGATGTGAGGGGGAGCGCAGAGGGGCTGCAGCGGGA AGGGGCACCCACGGGTCCAGTGCCTGGGGACAGCGCCTGCATAGGGGCCGCGGTGGCTCG CTCCCGGTGTTGGGATCCGAGGAGCGGGCAGAACCATCCTTACGAAGAGGGGGCTGAGTC CAGCTGGCCGGGCTTGGAGCCTTGAGGCGGGATTGAAGGAGGGAAGGACTGGGGTTAGGA GAGGAGTAGGGAATTAAGAGAATGAGGCTTTGAGGGGTTCGAAGGGTTTGGAGCCTGGGA CCTCAGGCTGTGACAGGGTTTCTCCTTTAGGATATGGGGCTCCTGGTGAAAGTGGAGCAG GAGCAGGGCCTGGAGAAAAGGGCATCTGAAATGGTCATCGTGGGGGAGGCCGTGGGAGAT CGTGGCGAGGTGGGGATGGGAAGCTCAGGGGCCACAGCCAGTTTAAGATCTGGGCAGCTG CGAATTCCCAGAAGGCAGGGGGGAGGAATGGGAGATGGAGCTGCTTGGCTAAGTTGGGGA CCTAGGGCCCCTGGGAGGGTGGCTGGATGCCAAGGAGAGTTGAATAGGGTTGGGGGAGCT GGCTGTGGCCCTTTGTCTTCCAGGCCCATCGGGAGCGGTGCAGGCAAGGAGCTCCTGGGA GGTGGGGCGGCTGGGGCTGCGGGGAAAGGCTTGGTCCCTTTCCCAGGATCCTGTGAATGG CTTTTGGCAGCCCGGCTCAGGAACGTGAGGGCTTGGGAGAGAGCTCCCAGGGGAGGGAGC CTCCGTGGAGTGGAGGGAGCCCTGTGTGGGCATTGTGGGGAGGGGTCCCAGGGCTGAGAA TGTAGAATGGGCAGCCCAGGAGATCCAGGAAGGAGGGCTGCTGACAACTGCATCTGTCAC TCCTCAGTCTCATGCCACTGTGGTGGGGGGTGCAGGAAAACTCTGTTATGGATTTGTCAC TGGGATGATTCATCCTGGTCCCCCAGGCCAGCTGCTAGGGAGACCCTTCCTTGTGCTTTT TCCAGGCTCTACCAGAAGGTCCTCACCCCTTCTAGGCCATAACTTCCCAAGCTCCAGAGC AGAGAGTCACCTGTCTCTGACTTGGGCTGGATTTGAGCATTTTCCAAGTAACCCTCAGTA CCTGGGACTGGGGGTCTGACTGTGTCTCCAGAGAGCTCCTGCTTCTCTTCTCCCCTGCCT CCTCCCCCTCTTGCCACCACACACATTGGCCATCACCACCTTTGTTAAGGCTGATAAGAG CATCTCCCTGAGGGTTGGCCAGCTTCCCTGAGCAAGGCGGAGGGCCATCCAGAGCCGGCA AGCCTGGCTGTGACTTGCCACCCTTCCTGCCTGCTCCAGAGGAGAGTTACGAGTGAGGCC TTTGACAGTGGAGGCGGGGTGGACACAGCAAATGGCCCTAGGGATGGCCTGAGGGGGCAG GGCCGGGGCCTCCCTGTGCCGGGCACTGTTGACCACTTCCATCACAAGAGCCTTTTGTTC CCTGCACAGGACACACTGAATAATAATTCTCTGGGCAAAAAGCACAGTTGGCAGGATCGG GTGTCTCGATCATCCTCACCCCTGAAGACAGGTAAGTCAGGGCCCTCTTCCTTACCTGGA CCTCCGCCTGCCCTGACTCAGTCCCCACTACAGAGAGCAAACCCTACAGTCTCCAAAGGG CTGAGTAGAGGTGAACTGCCCACCCACATCCCTGCACGAGCCCATCCAGGGGCTGAGATC AGTGGTGGCATGAGTGAGTTGACTGGCCCCAGAGCCTGCGAAGGGCCTGTTGCCCAGGGA GGCTTTGTCTTGGTTTCTGTGTCACCAAGCTGAGAGTGGCAGGTGCAGGTAGCTGGGAGT TGGGAGAGAGCCCCTGCCTTCATGACCTGCCTGCTCTCCAGGGGAGCAGACACCACCGCA TGAACACATCTGCCTGAGCGATGAGCTGCCCCCCCAGAGCGGCCCCGCCCCCACCACAGA TCGAGGCACCTCCACCGACAGCCCTTGCCGCCGCAGCACAGCCACCCAGATGGCACCTCC GGGTGGTCCCCCTGCTGCCCCGCCTGGGGGTCGGGGCCACTCGCATCGAGACCGAATCCA CTACCAGGCCGATGTGCGACTAGAGGCCACTGAGGAGATCTACCTGACCCCAGTGCAGAG GCCCCCAGACGCTGCAGAGCCCACCTCCGCCTTCCTGCCGCCCACTGAGAGCCGGATGTC AGTCAGCTCCGATCCAGACCCTGCCGCCTACCCCTCCACGGCAGGGCGGCCGCACCCCTC CATCAGTGAAGAGGAAGAGGGCTTCGACTGCCTGTCGTCCCCAGAGCGGGCTGAGCCCCC AGGCGGAGGGTGGCGGGGGAGCCTGGGGGAGCCGCCGCCACCTCCACGGGCCTCTCTGAG CTCGGACACCAGCGCCCTGTCCTATGACTCTGTCAAGTACACGCTGGTGGTAGATGAGCA TGCACAGCTGGAGCTGGTGAGCCTGCGGCCGTGCTTCGGAGACTACAGTGACGAGAGTGA CTCTGCCACCGTCTATGACAACTGTGCCTCCGTCTCCTCGCCCTATGAGTCGGCCATCGG AGAGGAATATGAGGAGGCCCCGCGGCCCCAGCCCCCTGCCTGCCTCTCCGAGGACTCCAC GCCTGATGAACCCGACGTCCATTTCTCCAAGAAATTCCTGAACGTCTTCATGAGTGGCCG CTCCCGCTCCTCCAGTGAGTCAGCAAGGGGAAGCAGTGGGGTGGGGGGGTCCCTAGCGGG GGCAGAGCCAAAATGCGAAGTGTTCTGGGAGGCGACCCCAGGCCCCATCTGGTTAGGACT GAGGCTTCTACCTGCCCCGCTAAACCTGGATCAGAGCTGCGACCCCCCATCCAGCCACAC CACCTCACCTGCAGGTGCTGAGTCCTTCGGGCTGTTCTCCTGCATCATCAACGGGGAGGA GCAGGAGCAGACCCACCGGGCCATATTCAGGTGAGAGCCATGGGCTGGCTGGGCCTAGCC AGGCAGCAGTTTGGGCCACACACCACCCTCTACTTGTCACCCCTACATGGCCTCAGCCTA ACCCCTGCCATCAGCCTTCATTTATCCACTCAGCCCTGGGAGGACAGTGTCCACTCTCTA GGGACTCAGAGTATGGTGACAAAGAGGATGGCTACAGTGAGGGATCCCAGAACTGTGCAC CTAGTCTGGCCAGGGGCAGGGCACCCAGGAGGGTGACCAGGAGGATGCCTGCCCACACCC CACCTGACCCTTCTCTAGACAAAAGCCTGCGCTTCCCACAGCCTCTCCATTTTAGAGGGG GCCCTGCCCACACCCTCCCTTGGCCTGTGTTTCCTCGATGGCAGATGCATGTCTGCTTGA CCTTGCTCTCCCCTGGGGTTAGTACTGCAACAGGCACACAGGATGCTTTTGCAAATGTTT ACTGAAATAACGATGCTGCTGTGGCTCCCAGACCCCAGAGTAGGCCTGGCTGGACAGGCC TTGGTGCCGAATTTCTCACCTGTCCTTGCTGGGGACAGGTTTGTGCCTCGACACGAAGAC GAACTTGAGCTGGAAGTGGATGACCCTCTGCTAGTGGAGCTCCAGGCTGAAGACTACTGG TACGAGGCCTACAACATGCGCACTGGTGCCCGGGGTGTCTTTCCTGCCTATTACGCCATC GAGGTCACCAAGGAGCCCGAGCACATGGCAGGTAGTGTTCCCTCCCTGGCCTGTGCCCCC AGCCACCACATCTGTCTGCCCCAACTTGCTGCTAGGTGAACGTGTACTCCAGATCTCAGC CAGCCAGGTGGGGGGCTGAGTGGAAGTGATTTTAGGTCCTTTTCACGATCAAGCAAAGTG AGGCCCGGCCAAGTTGGGCAGCCAGGGATTGTGGCAGCCTCTGTGGGCTCTGCCATTCCC CGTGCCTCACCCACCCTCCTTCACTTGGCTGCTCAGCTCCCTCCTGCTCTTTCTGCCCCT CCTCAATTCACGCTTGCTTTCCAGCCCTGGCCAAAAACAGTGACTGGGTGGACCAGTTCC GGGTGAAGTTCCTGGGCTCAGTCCAGGTTCCCTATCACAAGGGCAATGACGTCCTCTGTG CTGCTATGCAAAAGGTACCTGAGCCCTCTCCCTTCTCCTCCCTTGGATGGGTCCCTGGGG CAGAGGGACGCAGGTGTCTAGAGGCAGTAAAGGGCTCAGGCCCTGGGACAGGAGGGATCA GCAGAGGAACAGACAGCAGCTGACGTGGCTCCATTTGTCACCTGTAGATTGCCACCACCC GCCGGCTCACCGTGCACTTTAACCCGCCCTCCAGCTGTGTCCTGGAGATCAGCGTGCGGG GTGTGAAGATAGGCGTCAAGGCCGATGACTCCCAGGAGGCCAAGGTGACTTCTTCCAACC CAGCCCCTTCCTTCCATGGCCCCAAGCTCTCCCCCAAGACTTGTGATGAAGAGGCCATCT CCTGTCACCCTCACTGCAGGCCAGGTGACCGCCCTCTTGCTTCTTTTCTCCCTCCTGTAG GGGAATAAATGTAGCCACTTTTTCCAGTTAAAAAACATCTCTTTCTGCGGATATCATCCA AAGAACAACAAGTAAGTGGGGGTGGGATGGCAGTGGAGGAGGCACGGGTGGTCTGCAGCC TTGAGGTGGGTGGGTGTGGGCCGAGCCCCCGTCCCAGCACAGACAGACCTGTCCCTGCAG GTACTTTGGGTTCATCACCAAGCACCCCGCCGACCACCGGTTTGCCTGCCACGTCTTTGT GTCTGAAGACTCCACCAAAGCCCTGGCAGAGTCCGTGGGGTACGTGTACACCCTGCTGAG CACCCAGCCCGAGGGAGCACGCCCAATCCCAGGCCCTGGGGCTGCTTCCTGGCGCTCAGC TTTGCCCCTCGGTTTCCCCCGCAGCTCTGGAGAACTATCTCCGGACCCCAGTGCGGGTGG CCTGGAGGGAGGGTGGCGCGGCAGGGTGAGCCTGAGGAGCAGCTTCCAAGCTTGGTAGCT GTTGGGCCATGTCTTCAACTGACATCTTACTGGGAAACGCGATGGCAATTCTGTAGAGAA CAGAGCCAAGTGGCCCCAGCCAGAGGAACCAGAGCTGCACTTGGGCCCCAAGGCTCCAGC GGGAAAACCCTGGGTCGGGATCCTGTTCCTCCCTTGCCAGTGGCGATCTGAGCCATCTGT GTGTCCCCTGGCTTCTAGGAGAGCATTCCAGCAGTTCTACAAGCAGTTTGTGGAGTACAC CTGCCCCACAGAAGATATCTACCTGGAGTAGCTGTGCAGCCCCGCCCTCTGCGTCCCCCA GCCCTCAGGCCAGTGCCAGGACAGCTGGCTGCTGACAGGATGTGGCACTGCTTGAGGAGG GGCACCTGCCACCGCCAGAGGACAAGGAAGTGGGGGCCGCTGGCCCAGGGTAGGGGAGGG TGGGGCAATGGGGAGAGGCAAATGCAGTTTATTGTAATATATGGGATTAGATTCATCTAT GGAGGGCAGAGTGGGCTGCCTGGGGATTGGGAGGGACAGGGCTTGGGGAGCAGGTCTCTG GCAGAGAAGGATGTCCGTTCCAGGAGCACACGGCCCTGCCCCATCCTGGGCCTTACCTCC CCTGCCAGGGCTCGGGCGCTGTGGCTCCTGCCTTGATGAAGCCCGTGTCCTGCCTTGATG AAGCCTGTGCCACCTGCAAGTGCCCGCCCTGCCCCTGCCCCAACCCCCACCGAAGAGCCC TGAGCTCAGGCTGAGCCCAGCCACCTCCCAAGGACTTTCCAGTGAGGAAATGGCAACACG TGGAGGTGAAGTCCCTGTTCTCAGCTCCGTCATCTGCGGGGCTTCTGGGTGGCTCCTGCC ACTGACCTCACCGGCATGCTGGCCTGTGGCAGGCCTAGGACCTCAGGCGGGGAGGAGGAG CTGCCGCAAGGCCCTGTCCCAGCAGAAGAGGGAGGCTTCCTGACTGACACAGGCCAGCCC CATCTTGGTCCTGTCACCCTGGCCCCAACTATTAAAGTGCCATTTCCTGTCTGGA OMIM ID 604641