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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PSMF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9491
Official gene symbolPSMF1
Full nameproteasome (prosome, macropain) inhibitor subunit 1 (PI31)
Aliases,PI31,
Gene summaryThe 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq]
LocationChromosome: 20   Locus: 20p13
Gene position1093906 - 1148426  Map Viewer
Gene orientationplus
Gene size54521 bp
Gene sequence