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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ADAMTS4 (Homo sapiens) (Information is obtained from NCBI Gene database)

Entrez gene ID 9507 Official gene symbol ADAMTS4 Full name ADAM metallopeptidase with thrombospondin type 1 motif, 4 Aliases ,ADAMTS-2,ADAMTS-4,ADMP-1,KIAA0688, Gene summary This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq] Location Chromosome: 1   Locus: 1q21-q23 Gene position 161168845 - 161159538  Map Viewer Gene orientation minus Gene size 9308 bp Gene sequence >ADAMTS4:complement(12648180..12657487):Length=9308 GGGGAGAACCCACAGGGAGACCCACAGACACATATGCACGAGAGAGACAGAGGAGGAAAG AGACAGAGACAAAGGCACAGCGGAAGAAGGCAGAGACAGGGCAGGCACAGAAGCGGCCCA GACAGAGTCCTACAGAGGGAGAGGCCAGAGAAGCTGCAGAAGACACAGGCAGGGAGAGAC AAAGATCCAGGAAAGGAGGGCTCAGGAGGAGAGTTTGGAGAAGCCAGACCCCTGGGCACC TCTCCCAAGCCCAAGGACTAAGTTTTCTCCATTTCCTTTAACGGTCCTCAGCCCTTCTGA AAACTTTGCCTCTGACCTTGGCAGGAGTCCAAGCCCCCAGGCTACAGAGAGGAGCTTTCC AAAGCTAGGGTGTGGAGGACTTGGTGCCCTAGACGGCCTCAGTCCCTCCCAGCTGCAGTA CCAGTGCCATGTCCCAGACAGGCTCGCATCCCGGGAGGGGCTTGGCAGGGCGCTGGCTGT GGGGAGCCCAACCCTGCCTCCTGCTCCCCATTGTGCCGCTCTCCTGGCTGGTGTGGCTGC TTCTGCTACTGCTGGCCTCTCTCCTGCCCTCAGCCCGGCTGGCCAGCCCCCTCCCCCGGG AGGAGGAGATCGTGTTTCCAGAGAAGCTCAACGGCAGCGTCCTGCCTGGCTCGGGCGCCC CTGCCAGGCTGTTGTGCCGCTTGCAGGCCTTTGGGGAGACGCTGCTACTAGAGCTGGAGC AGGACTCCGGTGTGCAGGTCGAGGGGCTGACAGTGCAGTACCTGGGCCAGGCGCCTGAGC TGCTGGGTGGAGCAGAGCCTGGCACCTACCTGACTGGCACCATCAATGGAGATCCGGAGT CGGTGGCATCTCTGCACTGGGATGGGGGAGCCCTGTTAGGCGTGTTACAATATCGGGGGG CTGAACTCCACCTCCAGCCCCTGGAGGGAGGCACCCCTAACTCTGCTGGGGGACCTGGGG CTCACATCCTACGCCGGAAGAGTCCTGCCAGCGGTCAAGGTCCCATGTGCAACGTCAAGG CTCCTCTTGGAAGCCCCAGCCCCAGACCCCGAAGAGCCAAGGTAGGCATCTCTGGAGTCT GTGTCCTGCGGTGTCCTCCCGCCATGTCTGTCCTACTGACCCCTATTCACCCTCTCTCCA CCCACTTACACTTCTGGCCGTTCTGCTTCCCTCCCTTCTGCCTGCCTTTCCTTTCTCCAT GAGCCTCCTTTCTTGGTAAGGCTCAGGCCTCTCCCCTTCACCCTTCTCCTAGCCAGACCC ACCGAGGGTTCTCAGAGGTGGGTCACAGACTCTGGGCTGGGAATAACTGCTCCCTCTCCC CACCCCACCCCTTCCTGGCCATGGCATCTCCTACTGACACAGTCCCCAGCAGTAAAGGTC TCCTAACAGCCCCTTGGCCTTGGCTCTTTTCTCTGCTCCAAATTTGATTTTCATCCCCCA CTCCCAGCTATAGGAGTCAGGTTTGAGGCCCTAGGGCTTGGTGTCTGGCTTCTGATGCTG CCTTTAAAATCACTGTGGCAAACTGCAAACTAGGGCAGGAGTGGCAAGAGAGGGAGGGTA TCCCATACCTCCTTCTGGTCAATCCCCTTCACACACTGTGGCCGGACTGCGAGGCTGCCT GAGGCTCCATCCTTTCCTCCCTCCCACTCCTGGTCTCCCCCTTCTTCCCTTCCCTCCTCC CTCCTCCCTCTCTAGCTTTAATCCAGACCAGACGCTCCCTCCACAACCGCCACGCTGAGC TCTGGCCCTGGCCCTAGCTGCTGACTGAATCGTTCCTCCAACCACACAGGGCAGACACGT TGCAGCCCAGCCCTCTAGCCCTGGTCCCATAGGCCCCAGCCACACTCAGGCCTGGAGAAC CCCAAAGTCCCTCCTGACGGCAGTCCAGGCTGCTTTCACCTCTGGGGCTCCCGCAGCCCT GGGATGTGGCGTCCCCTTCTCCTCCCCTTCTTAGAACCAGCTGCTGACTCCTCAGAGTTA CCACAAAAGCCCTGAGATTTGGCGTTGGGGGAAGGGCCCAACCAAGACCCGCCAGGAGTC AGGAATCCCGTGGGGTGTGTGGGGCCCAGCTGACTATGCTGAGTTCCAGACCCAGGAAGT GAGGGATTGGAGAATCGACCGACCCATGGGTCTGAGAGGCTATTTCAGGATCTTCCTCTC CCTTTTTCTCTACAGCGCTTTGCTTCACTGAGTAGATTTGTGGAGACACTGGTGGTGGCA GATGACAAGATGGCCGCATTCCACGGTGCGGGGCTAAAGCGCTACCTGCTAACAGTGATG GCAGCAGCAGCCAAGGCCTTCAAGCACCCAAGCATCCGCAATCCTGTCAGCTTGGTGGTG ACTCGGCTAGTGATCCTGGGGTCAGGCGAGGAGGGGCCCCAAGTGGGGCCCAGTGCTGCC CAGACCCTGCGCAGCTTCTGTGCCTGGCAGCGGGGCCTCAACACCCCTGAGGACTCGGAC CCTGACCACTTTGACACAGCCATTCTGTTTACCCGTCAGGTGAGGCCCCAGTCAGCACCG CAGGCCATGCACTGCACAATTCTAAGAAGCGCCACTACATAGACTATGATGCAAATGATG TTCCTGGAGTTGTGTGACATGGTGCCTTGCCCCAGCCACACTGCCATGTGTGGCTACCTA GGCCCTGACAGTGCTGGGTCCTCAGTGCCCAGGTCCCCGGGAATCTGGATCTCAACCCAA TGGACCCAGGTGTCTTGGCTGTCTATGCACCTTCTATGATCCCTCTCCACAGGACCTGTG TGGAGTCTCCACTTGCGACACGCTGGGTATGGCTGATGTGGGCACCGTCTGTGACCCGGC TCGGAGCTGTGCCATTGTGGAGGATGATGGGCTCCAGTCAGCCTTCACTGCTGCTCATGA ACTGGGTAAAGTAGGGGTGGATGAGAAAGGTATTAGGGAGGAGAAGGTGGGGGAGGGGGT AGCAAGTTCACCACAGTGTTAATGGGGGTCCCAAGGTATTCTTCCCCCAGGCCTAGGTAT AGGGCTATTACTCCTCTCTGCTCCAGGTGTAGACATACATTTACATTTTTCTATTAAATA AATTAGTTGGTCGAAACTACTGTGAACTCCTCTGTGTGTGTGTGTGTGTGTGTGTGTGTG TCTGTGTGTGTGTATTTGGAGGGGGAGTCAGAGACAATGGGTGGGGTCACAGTTGGGAAT GTTGGCTATAAGGAAAAGTGGGTAGGGAGGGACCCTGAGTATATTTTGGGGAAGAGGAGA CAGAGAAAGAGACGGGGCTACATACTGGGAGCCCTGAGAGTACCATAAAGGAAAGGACTG GGGGCAGGGTGAGGTGGGTAATGGATCTGATCATCCACAGCTGCAGCCAGATTTATTATG GAGTCCCTCAGGGCATGGGGAAGGGACCCTCAGATCCTATCAGGGCCTTTGCTCCCACAG GTCATGTCTTCAACATGCTCCATGACAACTCCAAGCCATGCATCAGTTTGAATGGGCCTT TGAGCACCTCTCGCCATGTCATGGCCCCTGTGATGGCTCATGTGGATCCTGAGGAGCCCT GGTCCCCCTGCAGTGCCCGCTTCATCACTGACTTCCTGGACAATGGCTATGGTAAGCAGA TGGCACTTACCTTTCCCTGGGTAGCACTCAATTCCTGTCCTCCAGGGCACTCTCACTTCC GCTGCATTCTGCATGGACCAAATTGCCTCCCCCAAGTGTGCTTCCTCTGCAGTGTGGGAA GGGGTGAGAAATGCTGCTGTCTTTGTGTAGTTCTCACTTCCTCCCAGAATAAATAGCATA GCTAGAGGAGGCGAATTTTGGCTCAGTAGAATTAGAACTGACTTTCTGAGGGCCAGAACT GTCCACCACTGGAATGGGCTGGCTATGAAGGAGGTGATTACCTTGTCACGCAGTGAGGTA TGCAAGAATAGCAGGATGACTGCCACTAGGCAGAGATGTTGATGAGAAGCAAACTCAAAT ATTCTATAGTTGGTTAGAATAGGCAGAATTGAGTTCCTATCCTTACTCTGTTTTGTTTTG TTTTGTTTTGTTTTAAATACAGATGTGGTCTCACTGTGTTGCCTAGGCTGGTCTCGAACT CCTAGGCTCAAGCAATCCTCCCACCTCAGCCTTCCAAAGTGCTGGGATTACAGACATTAA GCCACCATGCCTGGCCTCTTATTCTGTTCTTTAAGCAGGTGTAGATGTGTGACTGTAAGT TACTTCACCTCTCTGTGTTTGTAGTTGATATGTCAGATAAGTATAATAGCGGTACCTATC TCATAGGTATTTGCCATGATTAAATAGTGCTGGTCAAGCATTTAGCCAATGCTCATCTCA TAATAAGCATCCAATAAACTATAGCTGCCCATTAAAGCCTCTTACAGGGCTAGGCACAGT GGCTTACACCTGTAATCCCAATGCTTTGGGAGGCTAAGGTGGGAGGATTGCTTGAGACCA GGAGTTTGAGATTAGCCTGGACAACATAGCAAGACCTTATCACTACAAAAAATTCCAAAA AATTAGCTGGACATGGCACATGCCTGTAATCCCAGCTACTCAGGAGCCCAAGGCAGGAAG TTTGCTTGAGCCCAGAAGTTTGAGGCTGTAGTGAGCCATGATCATGCCACTGTACTGCAG CCTGAGCGACAGAGCAAGACTCTGTCTCAGGAAAAAAAAAAAAAAGTAAGTAATTAAAAT AAAAATTATAAATAACAAAAATTTAAATCCTCTTATAGTCCTAGGATTGTTTTTCTAGGC TCCATCAGGCCCCAGGGAGCCTAAGCTTTCTGCTGGCAATCCTGAATGCTCCCCTCAGCC CGTTGCTGACTTTGTGCCCCAACCCCCTTCCCAGGGCACTGTCTCTTAGACAAACCAGAG GCTCCATTGCATCTGCCTGTGACTTTCCCTGGCAAGGACTATGATGCTGACCGCCAGTGC CAGCTGACCTTCGGGCCCGACTCACGCCATTGTCCACAGCTGCCGCCGCCCTGTGCTGCC CTCTGGTGCTCTGGCCACCTCAATGGCCATGCCATGTGCCAGACCAAACACTCGCCCTGG GCCGATGGCACACCCTGCGGGCCCGCACAGGCCTGCATGGGTGGTCGCTGCCTCCACATG GACCAGCTCCAGGACTTCAATGTGAGATCCTAGGGCAGGGGTGGGGTAAAGGGCCCGGGG GTGTGGGGACTGGCCTTAAGCCCAGGAGAGAGTTCACTTATGCCCCACTTCCGTTCTGTG CCTTTGCAGATTCCACAGGCTGGTGGCTGGGGTCCTTGGGGACCATGGGGTGACTGCTCT CGGACCTGTGGGGGTGGTGTCCAGTTCTCCTCCCGAGACTGCACGAGGCCTGTCCCCCGG AATGGTGGCAAGTACTGTGAGGGCCGCCGTACCCGCTTCCGCTCCTGCAACACTGAGGAC TGCCCAACTGGCTCAGGTGAGGAGTAGGGGGGATGGGAGCCCTTGGGAGGGGACAGTAGA GCAGGAAGGACTGTCCCTTGAGTGCAAGACCAAGGGGGTGTTGATTCCCCTGCTGCTGTG GGGAGTGCCTTTAACCTCTGGGAATTGTCCTTGGCCGTCTGCAGGGAAGAGCAGAGCTGT GCTGTCTAGAGTTCTCAGGGGTTGGGTGGAGGGATGTGGGGTGATGTGAGGAAGGAAGGA GGGGCTCTGACTGTTTTACCCCTCCAGCCCTGACCTTCCGCGAGGAGCAGTGTGCTGCCT ACAACCACCGCACCGACCTCTTCAAGAGCTTCCCAGGGCCCATGGACTGGGTTCCTCGCT ACACAGGCGTGGCCCCCCAGGACCAGTGCAAACTCACCTGCCAGGCCCAGGCACTGGGCT ACTACTATGTGCTGGAGCCACGGGTGAGGGTCAGGACACCCCCAGGCCCTGTCTATGGTC ACACACACCCGCAGTGCTCCCTCTGCTTTCTGATAACAAAGATCACCCAAAGTAACCCTG TTCCTACAGCCACGCCAGCCCAGTCCAGGATTCCACTCAGACTTATCTGTACATGGGTAT CAGGAAAACGAGCCCCAGACTCCAGATATGTGGCCAATAGGTCCCTCTAGCCTATCCTAT TTCCCGTGGTTTCTTTTCCTCTGACTCCCCATCTTCTAATGCTGCATTTGGTGAGAATCG AATGTGTGGCCTTTGGGACAAGTCCTTCACCCCTCTTCCATGGGCTCCTCTGTCAAATTA TAGTGGTGGTTTCATTCAGCTCCTGGACAGCCAGTCCCTCAATGGACAGGCCTCCTGGAG ATGACTGAAGTCCCTACACTCCCTCTCTGTGATAGGGTGGTGGGTTGAAGGCTGCACAAA GAAAAACAAGCCCCAGCAGCATTTTGCTCCCTTCGCCCCAACCTGAGAATTTCTACAGGC TGGCTGCCCTCTAGCGTCCATTTAGGGACAGTGCCATCAAGGTTTAGGGCTTGGTGCTGG GACCAGACAGACTGCACTTCCCATCTTGGCTCCTCTGCTTGCCATTTGTGTGGCTTTTGG ACAGGTTCTTTAGCTTTTCTAAACCTCAACGTTCCATCCCTAAAAACCTCAAATAGTGGT GGTGAGATTTACATTTGTGTTTATAAAACACTTAGCATGCTGCCTGATTCATACTCAGTG CTCTGAAAATGCTGGCTAGATGTTATATGTGATAATAATTATTATTGTTATGATTATCAC CCACATGGTGGCCGGCACTCACCCATCTACATCCCCTACTTCATCCAACTTTTCCGACAA CATTGCTTCCCTGATGGGACATGGGTCTCGTTTGATTTACCAACCCCTTTTGACTTAGGA GGAACCTTCAGCATTGTTCTTTCTCTTTTCCTCAGGTGGTAGATGGGACCCCCTGTTCCC CGGACAGCTCCTCGGTCTGTGTCCAGGGCCGATGCATCCATGCTGGCTGTGATCGCATCA TTGGCTCCAAGAAGAAGTTTGACAAGTGCATGGTGTGCGGAGGGGACGGTTCTGGTTGCA GCAAGCAGTCAGGCTCCTTCAGGAAATTCAGGTTCTTTCACCATCATTCCTCCCTCTACC TTCCTGGACATTCTGGGTCCTAGTGATGCAGAGGGGAACTCAGCACTGTTTCCACTCTCA AAGAGCTCACAGTCTAGCGGGAGATAGACGAGTAGGCAGCTACAGTGCGGTTTCCCATGT ATTCATCCGAAGTTGGAACAGGGTGTTGTGAGTGCCCTTGTGGGCATCAGGGAAGGCTTC CTTGGAGGTGACCTCTGAGCTGAGTCTCAGAAGGAGGGTAGGAATTAGACAGGTACCAAG GAAGTGGGGCTTGGAAGGGCAACTCAATAAGGGGGCAGTGGGTGTAAAGGTCCAGAGATA AGAGGCAGTAGGGCACATGTGCATGTAGCTCTGATCCAGACCGAACAGCTCACATAGGAT TGGGTGACAGCCATCTACACACATGTACACACATACAGTCACATAAGCACAGCTCAGAAG GCTGAGGGGATTCAGGTGATCCTGAGCTCCCCATCTACTCCTTCCACACAGGTACGGATA CAACAATGTGGTCACTATCCCCGCGGGGGCCACCCACATTCTTGTCCGGCAGCAGGGAAA CCCTGGCCACCGGAGCATCTACTTGGCCCTGAAGCTGCCAGATGGCTCCTATGCCCTCAA TGGTGAATACACGCTGATGCCCTCCCCCACAGATGTGGTACTGCCTGGGGCAGTCAGCTT GCGCTACAGCGGGGCCACTGCAGCCTCAGAGACACTGTCAGGCCATGGGCCACTGGCCCA GCCTTTGACACTGCAAGTCCTAGTGGCTGGCAACCCCCAGGACACACGCCTCCGATACAG CTTCTTCGTGCCCCGGCCGACCCCTTCAACGCCACGCCCCACTCCCCAGGACTGGCTGCA CCGAAGAGCACAGATTCTGGAGATCCTTCGGCGGCGCCCCTGGGCGGGCAGGAAATAACC TCACTATCCCGGCTGCCCTTTCTGGGCACCGGGGCCTCGGACTTAGCTGGGAGAAAGAGA GAGCTTCTGTTGCTGCCTCATGCTAAGACTCAGTGGGGAGGGGCTGTGGGCGTGAGACCT GCCCCTCCTCTCTGCCCTAATGCGCAGGCTGGCCCTGCCCTGGTTTCCTGCCCTGGGAGG CAGTGATGGGTTAGTGGATGGAAGGGGCTGACAGACAGCCCTCCATCTAAACTGCCCCCT CTGCCCTGCGGGTCACAGGAGGGAGGGGGAAGGCAGGGAGGGCCTGGGCCCCAGTTGTAT TTATTTAGTATTTATTCACTTTTATTTAGCACCAGGGAAGGGGACAAGGACTAGGGTCCT GGGGAACCTGACCCCTGACCCCTCATAGCCCTCACCCTGGGGCTAGGAAATCCAGGGTGG TGGTGATAGGTATAAGTGGTGTGTGTATGCGTGTGTGTGTGTGTGAAAATGTGTGTGTGC TTATGTATGAGGTACAACCTGTTCTGCTTTCCTCTTCCTGAATTTTATTTTTTGGGAAAA GAAAAGTCAAGGGTAGGGTGGGCCTTCAGGGAGTGAGGGATTATCTTTTTTTTTTTTTCT TTCTTTCTTTCTTTTTTTTTTTTGAGACAGAATCTCGCTCTGTCGCCCAGGCTGGAGTGC AATGGCACAATCTCGGCTCACTGCATCCTCCGCCTCCCGGGTTCAAGTGATTCTCATGCC TCAGCCTCCTGAGTAGCTGGGATTACAGGCTCCTGCCACCACGCCCGGCTAATTTTTGTT TTGTTTTGTTTGGAGACAGAGTCTCGCTATTGTCACCAGGGCTGGAATGATTTCAGCTCA CTGCAACCTTCGCCACCTGGGTTCCAGCAATTCTCCTGCCTCAGCCTCCCGAGTAGCTGA GATTATAGGCACCTACCACCACGCCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTT TCACCATGTTGGCCAGGCTGGTCTCGAACTCCTGACCTTAGGTGATCCACTCGCCTTCAT CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCACGCCCAACTAATTT TTGTATTTTTAGTAGAGACAGGGTTTCACCATGTTGGCCAGGCTGCTCTTGAACTCCTGA CCTCAGGTAATCGACCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACC ACGCCCGGTACATATTTTTTAAATTGAATTCTACTATTTATGTGATCCTTTTGGAGTCAG ACAGATGTGGTTGCATCCTAACTCCATGTCTCTGAGCATTAGATTTCTCATTTGCCAATA ATAATACCTCCCTTAGAAGTTTGTTGTGAGGATTAAATAATGTAAATAAAGAACTAGCAT AACACTCA OMIM ID 603876