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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for LITAF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9516
Official gene symbolLITAF
Full namelipopolysaccharide-induced TNF factor
Aliases,FLJ38636,MGC116698,MGC116700,MGC116701,MGC125274,MGC125275,MGC125276,PIG7,SIMPLE,TP53I7,
Gene summaryLipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16p13.13
Gene position11681322 - 11641578  Map Viewer
Gene orientationminus
Gene size39745 bp
Gene sequence
OMIM ID603795