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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for VPS4B (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9525
Official gene symbolVPS4B
Full namevacuolar protein sorting 4 homolog B (S. cerevisiae)
Aliases,MIG1,SKD1,SKD1B,VPS4-2,
Gene summaryThe protein encoded by this gene is a member of the AAA protein family (ATPases associated with diverse cellular activities), and is the homolog of the yeast Vps4 protein. In humans, two paralogs of the yeast protein have been identified. The former share a high degree of aa sequence similarity with each other, and also with yeast Vps4 and mouse Skd1 proteins. Mouse Skd1 (suppressor of K+ transport defect 1) has been shown to be a yeast Vps4 ortholog. Functional studies indicate that both human paralogs associate with the endosomal compartments, and are involved in intracellular protein trafficking, similar to Vps4 protein in yeast. The gene encoding this paralog has been mapped to chromosome 18; the gene for the other resides on chromosome 16. [provided by RefSeq]
LocationChromosome: 18   Locus: 18q21.32-q21.33
Gene position61089752 - 61056423  Map Viewer
Gene orientationminus
Gene size33330 bp
Gene sequence
OMIM ID609983