Entrez gene ID | | 9531 |
Official gene symbol | | BAG3 |
Full name | | BCL2-associated athanogene 3 |
Aliases | | ,BAG-3,BIS,CAIR-1,MGC104307, |
Gene summary | | BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10q25.2-q26.2 |
Gene position | | 121410882 - 121437331 Map Viewer |
Gene orientation | | plus |
Gene size | | 26450 bp |
Gene sequence |
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OMIM ID | | 603883 |