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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for BAG3 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9531
Official gene symbolBAG3
Full nameBCL2-associated athanogene 3
Aliases,BAG-3,BIS,CAIR-1,MGC104307,
Gene summaryBAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q25.2-q26.2
Gene position121410882 - 121437331  Map Viewer
Gene orientationplus
Gene size26450 bp
Gene sequence
OMIM ID603883