Entrez gene ID | | 9616 |
Official gene symbol | | RNF7 |
Full name | | ring finger protein 7 |
Aliases | | ,CKBBP1,ROC2,SAG, |
Gene summary | | The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3q22-q24 |
Gene position | | 141457051 - 141465243 Map Viewer |
Gene orientation | | plus |
Gene size | | 8193 bp |
Gene sequence |
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OMIM ID | | 603863 |
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