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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PPM1F (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9647
Official gene symbolPPM1F
Full nameprotein phosphatase, Mg2+/Mn2+ dependent, 1F
Aliases,CAMKP,CaMKPase,FEM-2,KIAA0015,POPX2,hFEM-2,
Gene summaryThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q11.22
Gene position22307250 - 22273792  Map Viewer
Gene orientationminus
Gene size33459 bp
Gene sequence