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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RAPGEF2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9693
Official gene symbolRAPGEF2
Full nameRap guanine nucleotide exchange factor (GEF) 2
Aliases,CNrasGEF,NRAPGEP,PDZ-GEF1,PDZGEF1,RA-GEF,Rap-GEP,nRap GEP,
Gene summaryMembers of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM]
LocationChromosome: 4   Locus: 4q32.1
Gene position160188998 - 160281302  Map Viewer
Gene orientationplus
Gene size92305 bp
Gene sequence
OMIM ID609530