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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ESPL1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9700
Official gene symbolESPL1
Full nameextra spindle pole bodies homolog 1 (S. cerevisiae)
Aliases,ESP1,FLJ46492,KIAA0165,
Gene summaryStable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM]
LocationChromosome: 12   Locus: 12q
Gene position53662083 - 53687427  Map Viewer
Gene orientationplus
Gene size25345 bp
Gene sequence
OMIM ID604143