Entrez gene ID | | 976 |
Official gene symbol | | CD97 |
Full name | | CD97 molecule |
Aliases | | ,TM7LN1, |
Gene summary | | This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13 |
Gene position | | 14492213 - 14519535 Map Viewer |
Gene orientation | | plus |
Gene size | | 27323 bp |
Gene sequence |
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OMIM ID | | 601211 |
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