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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CD97 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID976
Official gene symbolCD97
Full nameCD97 molecule
Aliases,TM7LN1,
Gene summaryThis gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found. [provided by RefSeq]
LocationChromosome: 19   Locus: 19p13
Gene position14492213 - 14519535  Map Viewer
Gene orientationplus
Gene size27323 bp
Gene sequence
OMIM ID601211