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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for CTIF (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9811
Official gene symbolCTIF
Full nameKIAA0427
Aliases,Gm672,KIAA0427,
Gene summaryCTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]).[supplied by OMIM]
LocationChromosome: 18   Locus: 18q21.1
Gene position46065427 - 46389588  Map Viewer
Gene orientationplus
Gene size324162 bp
Gene sequence
OMIM ID613178