Entrez gene ID | | 9817 |
Official gene symbol | | KEAP1 |
Full name | | kelch-like ECH-associated protein 1 |
Aliases | | ,INrf2,KIAA0132,KLHL19,MGC10630,MGC1114,MGC20887,MGC4407,MGC9454, |
Gene summary | | This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 19 Locus: 19p13.2 |
Gene position | | 10614054 - 10596796 Map Viewer |
Gene orientation | | minus |
Gene size | | 17259 bp |
Gene sequence |
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OMIM ID | | 606016 |
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