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Gene information for GAB2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9846
Official gene symbolGAB2
Full nameGRB2-associated binding protein 2
Aliases,KIAA0571,
Gene summaryThis gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq]
LocationChromosome: 11   Locus: 11q14.1
Gene position78128868 - 77926336  Map Viewer
Gene orientationminus
Gene size202533 bp
Gene sequence
OMIM ID606203