Entrez gene ID | | 9961 |
Official gene symbol | | MVP |
Full name | | major vault protein |
Aliases | | ,LRP,VAULT1, |
Gene summary | | This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p13.1-p11.2 |
Gene position | | 29831787 - 29859341 Map Viewer |
Gene orientation | | plus |
Gene size | | 27555 bp |
Gene sequence |
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OMIM ID | | 605088 |
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