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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TNFSF15 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9966
Official gene symbolTNFSF15
Full nametumor necrosis factor (ligand) superfamily, member 15
Aliases,MGC129934,MGC129935,TL1,TL1A,VEGI,VEGI192A,
Gene summaryThe protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q32
Gene position117568408 - 117551600  Map Viewer
Gene orientationminus
Gene size16809 bp
Gene sequence
OMIM ID604052