Entrez gene ID | | 9988 |
Official gene symbol | | DMTF1 |
Full name | | cyclin D binding myb-like transcription factor 1 |
Aliases | | ,DMP1,DMTF,FLJ25188,FLJ41265,FLJ76054,hDMP1, |
Gene summary | | This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q21 |
Gene position | | 86781677 - 86825648 Map Viewer |
Gene orientation | | plus |
Gene size | | 43972 bp |
Gene sequence |
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OMIM ID | | 608491 |