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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for DMTF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID9988
Official gene symbolDMTF1
Full namecyclin D binding myb-like transcription factor 1
Aliases,DMP1,DMTF,FLJ25188,FLJ41265,FLJ76054,hDMP1,
Gene summaryThis gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 7   Locus: 7q21
Gene position86781677 - 86825648  Map Viewer
Gene orientationplus
Gene size43972 bp
Gene sequence
OMIM ID608491