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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for RAD50 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000019 regulation of mitotic recombination IDA GO:0000723 telomere maintenance TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006281 DNA repair IDA GO:0006281 DNA repair IEA GO:0006281 DNA repair TAS GO:0006302 double-strand break repair IMP GO:0006302 double-strand break repair TAS GO:0006310 DNA recombination IDA GO:0007004 telomere maintenance via telomerase IDA GO:0007049 cell cycle IEA GO:0007126 meiosis IEA GO:0007131 reciprocal meiotic recombination TAS GO:0031954 positive regulation of protein autophosphorylation IDA GO:0032508 DNA duplex unwinding IMP GO:0033674 positive regulation of kinase activity IDA cellular_component GO:0000784 nuclear chromosome, telomeric region IDA GO:0005654 nucleoplasm TAS GO:0005694 chromosome IEA GO:0030870 Mre11 complex IDA GO:0030870 Mre11 complex IEA GO:0045120 pronucleus IEA molecular_function GO:0000014 single-stranded DNA specific endodeoxyribonuclease activity IDA GO:0000166 nucleotide binding IEA GO:0003677 DNA binding IDA GO:0004003 ATP-dependent DNA helicase activity IMP GO:0004518 nuclease activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008270 zinc ion binding IEA GO:0008408 3'-5' exonuclease activity IDA GO:0016787 hydrolase activity IEA GO:0030674 protein binding, bridging IDA GO:0046872 metal ion binding IEA

Protein-protein interaction details for RAD50 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID HNF4A Affinity Capture-MS physical 17353931 H2AFX Co-localization physical 10959836 BLM Co-purification physical 10783165 BRCA1 Co-purification physical 10783165 MRE11A Co-purification physical 10783165 NBN Co-purification physical 10783165 MRE11A Co-purification physical 11504724 MRE11A Affinity Capture-Western physical 11504724 BRCA1 Co-purification physical 11504724 MRE11A Affinity Capture-Western physical 11504724 NBN Affinity Capture-Western physical 12679336 BRCA1 Two-hybrid physical 10426999 BRCA1 Affinity Capture-Western physical 10426999 BRCA1 Reconstituted Complex physical 10426999 BRCA1 Co-localization physical 10426999 ATM Co-purification physical 10783165 MLH1 Co-purification physical 10783165 MSH2 Co-purification physical 10783165 MSH6 Co-purification physical 10783165 RFC1 Co-purification physical 10783165 TERF2 Affinity Capture-Western physical 15100233 TERF2IP Affinity Capture-Western physical 15100233 TERF2IP Affinity Capture-MS physical 15100233 MDC1 Affinity Capture-Western physical 14519663 MRE11A Affinity Capture-Western physical 8756642 MRE11A Affinity Capture-Western physical 8756642 RINT1 Two-hybrid physical 11096100 RINT1 Reconstituted Complex physical 11096100 RINT1 Affinity Capture-Western physical 11096100 RINT1 Affinity Capture-Western physical 11096100 MRE11A Co-purification physical 9705271 NBN Co-purification physical 9705271 CHEK2 Affinity Capture-Western physical 17525332 NBN Affinity Capture-Western physical 11238951 TERF2 Affinity Capture-MS physical 10888888 TERF2 Affinity Capture-Western physical 10888888 MRE11A Affinity Capture-Western physical 10508516 RECQL5 Affinity Capture-MS physical 19270065 RECQL5 Affinity Capture-Western physical 19270065 MRE11A Affinity Capture-Western physical 19270065 RECQL5 Reconstituted Complex physical 19270065 TERF2 Affinity Capture-Western physical 18212065 USP11 Affinity Capture-MS physical 19615732 USP42 Affinity Capture-MS physical 19615732 USP53 Affinity Capture-MS physical 19615732 DDX1 Affinity Capture-Western physical 18710941 SUMO2 Affinity Capture-MS physical 19394292 BRCA1 Affinity Capture-Western physical 16260778 KAT2A Affinity Capture-Western physical 16260778 MRE11A Affinity Capture-MS physical 12607003 MRE11A Affinity Capture-Western physical 12607003 MDC1 Affinity Capture-Western physical 12607003 MRE11A Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 MDC1 Affinity Capture-Western physical 12607003 NBN Affinity Capture-Western physical 12607003 PHF1 Affinity Capture-MS physical 18385154 H2AFX Affinity Capture-Western physical 15201865 PAXIP1 Affinity Capture-MS physical 17925232 PAXIP1 Affinity Capture-MS physical 17500065 PAXIP1 Affinity Capture-Western physical 17500065 MRE11A Affinity Capture-Western physical 17500065 MRE11A Affinity Capture-Western physical 17500065 NBN Affinity Capture-Western physical 17500065 SIP1 Two-hybrid physical 20403813 SIP1 Affinity Capture-Western physical 20403813 SIP1 Affinity Capture-Western physical 20403813 DCLRE1B Affinity Capture-Western physical 18469862 DCLRE1B Affinity Capture-Western physical 18469862 KAT5 Affinity Capture-Western physical 20070254 TERF1 Affinity Capture-MS physical 20811636 NBN Affinity Capture-Western physical 12447395 HDAC5 Affinity Capture-MS physical 21081666 EP300 Affinity Capture-MS physical 16051665 TERF2IP Affinity Capture-MS physical 15383534 BARD1 Co-purification physical 16391231 BARD1 Affinity Capture-Western physical 16391231 BRCA1 Affinity Capture-Western physical 16391231 NBN Affinity Capture-Western physical 16391231 MRE11A Affinity Capture-Western physical 16391231 RBBP8 Affinity Capture-Western physical 16391231 TOPBP1 Affinity Capture-Western physical 16391231