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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CDKN1B (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000079 regulation of cyclin-dependent protein kinase activity TAS GO:0000080 G1 phase of mitotic cell cycle TAS GO:0000082 G1/S transition of mitotic cell cycle IDA GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000084 S phase of mitotic cell cycle TAS GO:0000278 mitotic cell cycle TAS GO:0006813 potassium ion transport IEA GO:0006917 induction of apoptosis IDA GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0007049 cell cycle EXP GO:0007050 cell cycle arrest IEA GO:0007050 cell cycle arrest IMP GO:0007605 sensory perception of sound IEA GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation IMP GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0016310 phosphorylation TAS GO:0030308 negative regulation of cell growth IDA GO:0031116 positive regulation of microtubule polymerization IEA GO:0033673 negative regulation of kinase activity IDA GO:0042326 negative regulation of phosphorylation IDA GO:0043066 negative regulation of apoptosis IEA GO:0045732 positive regulation of protein catabolic process IDA GO:0045736 negative regulation of cyclin-dependent protein kinase activity IEA GO:0045892 negative regulation of transcription, DNA-dependent IDA GO:0048011 nerve growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048102 autophagic cell death IDA GO:0048839 inner ear development IEA GO:0051271 negative regulation of cellular component movement IEA GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development IEA GO:0071236 cellular response to antibiotic IEA GO:0071285 cellular response to lithium ion IDA GO:0071407 cellular response to organic cyclic compound IEA cellular_component GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005768 endosome IEA GO:0005829 cytosol IEA GO:0005829 cytosol TAS molecular_function GO:0004693 cyclin-dependent protein kinase activity EXP GO:0004693 cyclin-dependent protein kinase activity TAS GO:0004860 protein kinase inhibitor activity IEA GO:0004861 cyclin-dependent protein kinase inhibitor activity IEA GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity TAS GO:0005515 protein binding IPI GO:0016301 kinase activity IEA GO:0016301 kinase activity TAS GO:0019903 protein phosphatase binding IPI

Protein-protein interaction details for CDKN1B (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID NUP50 Two-hybrid physical 10891500 CCND2 Two-hybrid physical 16189514 TRAF2 Two-hybrid physical 16189514 CCND3 Two-hybrid physical 16189514 CDK2 Affinity Capture-Western physical 15619620 SPDYA Reconstituted Complex physical 12972555 SPDYA Reconstituted Complex physical 12972555 SPDYA Affinity Capture-Western physical 12972555 CDK2 Affinity Capture-Western physical 12972555 CCNA2 Affinity Capture-Western physical 12947099 SKP2 Biochemical Activity physical 12813041 CKS1B Biochemical Activity physical 12813041 CCNE1 Affinity Capture-Western physical 9891079 ARHGDIA Two-hybrid physical 16169070 COPS5 Affinity Capture-Western physical 12082530 UCHL1 Affinity Capture-Western physical 12082530 SKP2 Reconstituted Complex physical 12140288 CKS1B Reconstituted Complex physical 12140288 CDK2 Affinity Capture-Western physical 12417722 CDK6 Affinity Capture-Western physical 11360184 CCND3 Affinity Capture-Western physical 11360184 CDK4 Reconstituted Complex physical 11360184 CCND3 Reconstituted Complex physical 11360184 CCND1 Reconstituted Complex physical 11360184 CCND3 Affinity Capture-Western physical 10342870 XPO1 Affinity Capture-Western physical 11889117 CDK2 Affinity Capture-Western physical 15355997 TSC1 Affinity Capture-Western physical 15355997 TSC2 Affinity Capture-Western physical 15355997 AKT1 Biochemical Activity physical 12042314 SKP2 Affinity Capture-Western physical 12042314 AKT1 Affinity Capture-Western physical 12042314 YWHAQ Affinity Capture-Western physical 12042314 NUP50 Reconstituted Complex physical 10891500 GRB2 Reconstituted Complex physical 11278754 GRB2 Co-fractionation physical 11278754 XPO1 Affinity Capture-Western physical 12529437 XPO1 Reconstituted Complex physical 12529437 XPO1 Affinity Capture-Western physical 12529437 CCNE1 Affinity Capture-Western physical 12529437 CDK2 Affinity Capture-Western physical 12529437 CCNE1 Affinity Capture-Western physical 12529437 CDK4 Affinity Capture-Western physical 10908655 UBE2D2 Biochemical Activity physical 19123975 UBE2B Biochemical Activity physical 19123975 CDC34 Biochemical Activity physical 19123975 CUL4A Affinity Capture-Western physical 19056892 SKP2 Biochemical Activity physical 16774918 CCNA1 Reconstituted Complex physical 16774918 COPS5 Reconstituted Complex physical 16951171 COPS5 Reconstituted Complex physical 16951171 COPS5 Affinity Capture-Western physical 16951171 TRIM21 Affinity Capture-Western physical 16880511 CUL4A Affinity Capture-Western physical 16537899 RNF123 Affinity Capture-Western physical 15746103 UBC Affinity Capture-Western physical 15735731 SKP2 Affinity Capture-Western physical 15735731 UBC Affinity Capture-Western physical 15695403 CCND1 Affinity Capture-Western physical 15695403 CDK4 Affinity Capture-Western physical 15695403 UBAC1 Reconstituted Complex physical 15531880 RNF123 Reconstituted Complex physical 15531880 SKP2 Affinity Capture-Western physical 15469821 UBC Affinity Capture-Western physical 15469821 CDK2 Affinity Capture-Western physical 15647383 CDK2 Affinity Capture-Western physical 15557281 CCND3 Affinity Capture-Western physical 10597239 CCND3 Affinity Capture-Western physical 10597239 UBB Affinity Capture-Western physical 21237244 DDB1 Affinity Capture-Western physical 21237244 SKP2 Affinity Capture-Western physical 21237244 CCNE1 Affinity Capture-Western physical 17293600 UBC Affinity Capture-Western physical 10323868 UBC Affinity Capture-Western physical 10318797 UBE3A Affinity Capture-Western physical 19591933 UBE3A Biochemical Activity physical 19591933 UBC Affinity Capture-Western physical 19591933 RCHY1 Affinity Capture-Western physical 18006823 UBC Affinity Capture-Western physical 18006823 RCHY1 Biochemical Activity physical 18006823 CCNE1 Affinity Capture-Western physical 20837141 CDK4 Affinity Capture-Western physical 20837141 SKP2 Affinity Capture-Western physical 19686743 UBC Affinity Capture-Western physical 19686743 UBC Affinity Capture-Western physical 19451650 PIN1 Reconstituted Complex physical 19584057 PIN1 Affinity Capture-Western physical 19584057 PIN1 Protein-peptide physical 19584057 CKS1B Affinity Capture-Western physical 19584057 UBC Affinity Capture-Western physical 20940304 KPNA4 Reconstituted Complex physical 15057270 KPNA1 Reconstituted Complex physical 15057270 KPNA1 Affinity Capture-Western physical 15057270 KPNA1 Protein-peptide physical 15057270 YWHAE Affinity Capture-Western physical 15057270 YWHAE Reconstituted Complex physical 15057270 YWHAB Reconstituted Complex physical 15057270 YWHAZ Reconstituted Complex physical 15057270 UBC Affinity Capture-Western physical 21358672 UBC Affinity Capture-Western physical 21358672