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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CFTR (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0006695 cholesterol biosynthetic process IEA GO:0006810 transport TAS GO:0006811 ion transport IEA GO:0006821 chloride transport TAS GO:0006833 water transport IEA GO:0007585 respiratory gaseous exchange TAS GO:0015701 bicarbonate transport IEA GO:0015705 iodide transport IEA GO:0030301 cholesterol transport IEA GO:0030321 transepithelial chloride transport IEA GO:0030324 lung development IEA GO:0032870 cellular response to hormone stimulus IEA GO:0034097 response to cytokine stimulus IEA GO:0042493 response to drug IEA GO:0043434 response to peptide hormone stimulus IEA GO:0043627 response to estrogen stimulus IEA GO:0045909 positive regulation of vasodilation IEA GO:0055085 transmembrane transport IEA GO:0055085 transmembrane transport TAS cellular_component GO:0005737 cytoplasm IEA GO:0005769 early endosome IDA GO:0005902 microvillus IEA GO:0016020 membrane IEA GO:0016020 membrane TAS GO:0016021 integral to membrane IEA GO:0016323 basolateral plasma membrane IEA GO:0016323 basolateral plasma membrane NAS GO:0016324 apical plasma membrane IDA GO:0016324 apical plasma membrane IEA GO:0030659 cytoplasmic vesicle membrane IEA GO:0031205 endoplasmic reticulum Sec complex IDA GO:0031901 early endosome membrane IEA GO:0034707 chloride channel complex IEA GO:0043234 protein complex IDA molecular_function GO:0000166 nucleotide binding IEA GO:0005216 ion channel activity IEA GO:0005224 ATP-binding and phosphorylation-dependent chloride channel activity TAS GO:0005254 chloride channel activity IEA GO:0005254 chloride channel activity TAS GO:0005260 channel-conductance-controlling ATPase activity NAS GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016787 hydrolase activity IEA GO:0016887 ATPase activity IEA GO:0019899 enzyme binding IPI GO:0030165 PDZ domain binding IDA GO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA

Protein-protein interaction details for CFTR (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID GOPC Two-hybrid physical 11707463 KCNJ1 Affinity Capture-Western physical 14604981 PDZD3 Reconstituted Complex physical 12615054 SLC9A3R1 Reconstituted Complex physical 12615054 SLC9A3R1 Reconstituted Complex physical 9613608 SLC9A3R1 Affinity Capture-Western physical 9613608 STX1A Reconstituted Complex physical 9384384 STX1A Affinity Capture-Western physical 9384384 HSPA8 Affinity Capture-Western physical 10075921 DNAJB1 Affinity Capture-Western physical 10075921 DNAJA1 Affinity Capture-Western physical 10075921 PRKCE Affinity Capture-Western physical 11956211 PRKCE Affinity Capture-Western physical 11956211 SNAP23 Affinity Capture-Western physical 12209004 STX1A Affinity Capture-Western physical 12209004 SNAP23 Reconstituted Complex physical 12209004 PRKAA1 Reconstituted Complex physical 10862786 SLC9A3R1 Affinity Capture-Western physical 10852925 SLC9A3R1 Reconstituted Complex physical 12471024 PDZK1 Reconstituted Complex physical 12471024 GOPC Reconstituted Complex physical 12471024 PDZK1 Affinity Capture-Western physical 12471024 CLCN3 Reconstituted Complex physical 12471024 SLC9A3R1 Reconstituted Complex physical 9671706 SLC9A3R2 Affinity Capture-Western physical 10893422 EZR Affinity Capture-Western physical 10893422 SLC9A3R2 Reconstituted Complex physical 10893422 GOPC Affinity Capture-Western physical 11707463 SLC9A3R1 Reconstituted Complex physical 9677412 SLC9A3R1 Protein-peptide physical 9677412 SLC9A3R1 Protein-peptide physical 9677412 SLC4A8 Affinity Capture-Western physical 12403779 SLC4A8 Affinity Capture-Western physical 12403779 SLC9A3R1 Affinity Capture-Western physical 12403779 SLC9A3R1 Reconstituted Complex physical 12403779 CFTR Affinity Capture-Western physical 11051556 PDZK1 Affinity Capture-Western physical 11051556 DNAJC5 Affinity Capture-Western physical 12039948 DNAJC5 Affinity Capture-Western physical 12039948 DNAJC5 Reconstituted Complex physical 12039948 UBC Affinity Capture-Western physical 18216283 AMFR Affinity Capture-Western physical 18216283 VCP Affinity Capture-Western physical 16621797 STUB1 Biochemical Activity physical 15611333 HSPA8 Affinity Capture-Western physical 15611333 HDAC6 Affinity Capture-Western physical 14675537 UBC Reconstituted Complex physical 10982807 HSP90AA1 Reconstituted Complex physical 10982807 HSPA8 Reconstituted Complex physical 10982807 HSPA8 Affinity Capture-Western physical 10666020 UBC Affinity Capture-Western physical 19307599 HSPA8 Affinity Capture-Western physical 21697503 USP10 Affinity Capture-Western physical 20215869 PRKAA1 Biochemical Activity physical 20861072 COMMD1 Affinity Capture-Western physical 21483833 COMMD1 Affinity Capture-Western physical 21483833 COMMD1 Co-localization physical 21483833 CBL Affinity Capture-Western physical 20525683 CBL Affinity Capture-Western physical 20525683 UBC Affinity Capture-Western physical 20525683 NEDD4 Affinity Capture-Western physical 19617352 UBC Affinity Capture-Western physical 19617352 UBC Affinity Capture-Western physical 19269966 JKAMP Affinity Capture-Western physical 19269966 RNF5 Affinity Capture-Western physical 19269966 UBE3A Co-localization physical 19233847 VCP Affinity Capture-Western physical 19828134 AMFR Affinity Capture-Western physical 19828134 UBC Affinity Capture-Western physical 19828134 UBC Affinity Capture-Western physical 20147297 STUB1 Biochemical Activity physical 19056735 STUB1 Biochemical Activity physical 21898230