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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for WDR5 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0001501 skeletal system development IEA GO:0006355 regulation of transcription, DNA-dependent IEA GO:0016568 chromatin modification IEA GO:0043966 histone H3 acetylation IDA GO:0051568 histone H3-K4 methylation IDA cellular_component GO:0005622 intracellular IEA GO:0005634 nucleus IEA GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex IDA GO:0035097 histone methyltransferase complex IDA GO:0048188 Set1C/COMPASS complex IDA GO:0071339 MLL1 complex IDA molecular_function GO:0005515 protein binding IPI GO:0042800 histone methyltransferase activity (H3-K4 specific) IDA

Protein-protein interaction details for WDR5 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MBIP Two-hybrid physical 16189514 PASK Affinity Capture-MS physical 17353931 MLL Affinity Capture-Western physical 15199122 ASH2L Reconstituted Complex physical 15199122 HCFC1 Co-purification physical 15199122 HCFC2 Co-purification physical 15199122 MEN1 Co-purification physical 15199122 MLL Co-purification physical 15199122 MLL Affinity Capture-Western physical 15199122 RBBP5 Co-purification physical 15199122 HCFC1 Affinity Capture-MS physical 12670868 CXXC1 Affinity Capture-Western physical 19433449 CXXC1 Affinity Capture-MS physical 16253997 RBBP5 Affinity Capture-Western physical 16253997 SETD1A Affinity Capture-Western physical 16253997 ASH2L Affinity Capture-Western physical 16253997 CXXC1 Affinity Capture-Western physical 16253997 KDM6A Affinity Capture-MS physical 17761849 CXXC1 Affinity Capture-Western physical 18082152 CHD8 Reconstituted Complex physical 18378692 CHD8 Affinity Capture-Western physical 18378692 CXXC1 Affinity Capture-Western physical 18680430 SETD1B Affinity Capture-MS physical 17355966 SETD1B Affinity Capture-Western physical 17355966 SETD1A Affinity Capture-Western physical 17355966 SETD1A Affinity Capture-Western physical 17355966 SETD1B Affinity Capture-Western physical 17355966 PHF8 Affinity Capture-Western physical 20208542 PHF8 Co-localization physical 20208542 MYB Affinity Capture-Western physical 20093773 CHD8 Reconstituted Complex physical 20085832 IKBKG Reconstituted Complex physical 20098747 ZNF335 Affinity Capture-Western physical 19131338 KIAA1267 Affinity Capture-Western physical 19854137 NCOA6 Affinity Capture-MS physical 19047629 CUL4A Affinity Capture-Western physical 17041588 CUL4B Affinity Capture-Western physical 17041588 RBBP5 Affinity Capture-Western physical 17041588 DTL Affinity Capture-Western physical 17041588 GRWD1 Affinity Capture-Western physical 17041588 RFWD2 Affinity Capture-Western physical 17041588 SNRNP40 Affinity Capture-Western physical 17041588 WDR26 Affinity Capture-Western physical 17041588 WDR5B Affinity Capture-Western physical 17041588 PAFAH1B1 Affinity Capture-Western physical 17041588 NLE1 Affinity Capture-Western physical 17041588 WDR12 Affinity Capture-Western physical 17041588 CIAO1 Affinity Capture-Western physical 17041588 WDR53 Affinity Capture-Western physical 17041588 WDR59 Affinity Capture-Western physical 17041588 WDR61 Affinity Capture-Western physical 17041588 HIST1H3A Affinity Capture-Western physical 17041588 HIST1H3A Reconstituted Complex physical 17041588 NCOA6 Affinity Capture-Western physical 17021013 MLL Reconstituted Complex physical 18840606 MLLT1 Co-crystal Structure physical 18829459 MLLT1 Reconstituted Complex physical 18829457 HIST1H3A Co-crystal Structure physical 16946699 HIST1H3A Co-crystal Structure physical 16829960 HIST1H3A Co-crystal Structure physical 16829959 HIST1H3A Co-crystal Structure physical 16600877 TP53 Reconstituted Complex physical 15960975 MYST1 Affinity Capture-Western physical 15960975 HIST1H3A Affinity Capture-MS physical 15960974 HIST1H3A Affinity Capture-Western physical 15960974 HIST1H3A Reconstituted Complex physical 15960974 HIST1H3A Affinity Capture-Western physical 15960974 ASH2L Affinity Capture-Western physical 15960974 RBBP5 Affinity Capture-Western physical 15960974 MLL2 Affinity Capture-Western physical 15960974 RBBP5 Affinity Capture-Western physical 15960974 HIST1H1C Affinity Capture-MS physical 18258596 HIST1H1C Affinity Capture-Western physical 18258596 HIST1H1C Reconstituted Complex physical 18258596 PAX7 Affinity Capture-MS physical 18066051 PAX7 Affinity Capture-Western physical 18066051 PAX7 Affinity Capture-Western physical 18066051 ASH2L Affinity Capture-Western physical 18066051 ASH2L Affinity Capture-Western physical 18066051 PAXIP1 Affinity Capture-MS physical 17925232 ASH2L Affinity Capture-Western physical 17925232 MLL2 Affinity Capture-Western physical 17925232 PAXIP1 Affinity Capture-Western physical 17925232 NCOA6 Affinity Capture-Western physical 17925232 RBBP5 Affinity Capture-Western physical 17925232 USF1 Affinity Capture-MS physical 17846119 PAXIP1 Affinity Capture-MS physical 17500065 PAXIP1 Affinity Capture-Western physical 17500065 PAXIP1 Co-purification physical 17500065 PAXIP1 Affinity Capture-Western physical 17500065 RBBP5 Affinity Capture-Western physical 17500065 C16orf53 Affinity Capture-Western physical 17500065 POU5F1 Affinity Capture-Western physical 21477851 POU5F1 Co-purification physical 21477851 POU5F1 Affinity Capture-Western physical 21477851 POU5F1 Reconstituted Complex physical 21477851 MYST1 Affinity Capture-MS physical 20479123 KDM1B Affinity Capture-MS physical 20670891 ASH2L Affinity Capture-Western physical 21285357 RBBP5 Reconstituted Complex physical 21220120 RBBP5 Protein-peptide physical 21220120 RBBP5 Co-crystal Structure physical 21220120 MLL Co-crystal Structure physical 21220120 MLL Affinity Capture-Western physical 20581860 MYST3 Affinity Capture-Western physical 20581860 WDR82 Affinity Capture-MS physical 20516061 WDR82 Affinity Capture-Western physical 20516061 TADA2A Affinity Capture-MS physical 20508642 TERF2 Affinity Capture-MS physical 20811636 PSMC5 Co-localization physical 19660582 CREBBP Affinity Capture-Western physical 19660582 CARM1 Affinity Capture-Western physical 19660582 MAX Affinity Capture-MS physical 20946988 PYGO2 Reconstituted Complex physical 20937768 PYGO2 Affinity Capture-Western physical 20937768 UBC Affinity Capture-MS physical 16196087 HIST3H3 Biochemical Activity physical 21124902 HIST3H3 Protein-peptide physical 21135039 HIST3H3 Co-crystal Structure physical 21135039 HDAC5 Affinity Capture-MS physical 21081666 ESR1 Affinity Capture-Western physical 16603732 ESR1 Affinity Capture-MS physical 16603732 ASH2L Affinity Capture-Western physical 16603732 MLL2 Affinity Capture-Western physical 16603732 RBBP5 Affinity Capture-Western physical 16603732 PSMA3 Affinity Capture-MS physical 22079093 MAVS Affinity Capture-Western physical 20080758 TRAF3 Affinity Capture-Western physical 20080758 TRAF6 Affinity Capture-Western physical 20080758 MOXD1 Affinity Capture-Western physical 20581860