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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for CHEK1 (Homo sapiens) (Information is obtained from AmiGO)

ID Term Evidence biological_process GO:0000075 cell cycle checkpoint TAS GO:0000077 DNA damage checkpoint IDA GO:0000077 DNA damage checkpoint IMP GO:0000079 regulation of cyclin-dependent protein kinase activity TAS GO:0000086 G2/M transition of mitotic cell cycle IEA GO:0006260 DNA replication TAS GO:0006281 DNA repair IEA GO:0006281 DNA repair IMP GO:0006975 DNA damage induced protein phosphorylation IDA GO:0006975 DNA damage induced protein phosphorylation IEA GO:0007049 cell cycle IEA GO:0007131 reciprocal meiotic recombination TAS GO:0008285 negative regulation of cell proliferation TAS GO:0010569 regulation of double-strand break repair via homologous recombination IDA GO:0018107 peptidyl-threonine phosphorylation IDA GO:0031572 G2/M transition DNA damage checkpoint IEA GO:0033261 regulation of S phase IEA GO:0045839 negative regulation of mitosis IDA GO:0046602 regulation of mitotic centrosome separation IDA GO:0071260 cellular response to mechanical stimulus IEP GO:0071310 cellular response to organic substance IEA GO:0071313 cellular response to caffeine IEA GO:0090399 replicative senescence NAS cellular_component GO:0000781 chromosome, telomeric region IDA GO:0000794 condensed nuclear chromosome IDA GO:0005634 nucleus IDA GO:0005634 nucleus IEA GO:0005654 nucleoplasm IEA GO:0005654 nucleoplasm TAS GO:0005657 replication fork IEA GO:0005737 cytoplasm IEA GO:0005813 centrosome IDA GO:0005856 cytoskeleton IEA molecular_function GO:0000166 nucleotide binding IEA GO:0004672 protein kinase activity IEA GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity IEA GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016772 transferase activity, transferring phosphorus-containing groups IEA

Protein-protein interaction details for CHEK1 (Homo sapiens) (Information is obtained from BioGRID)

Interacting human protein Experiment Type PubMed ID MSH2 Affinity Capture-Western physical 15647386 CDC25A Reconstituted Complex physical 12963847 CSNK2A1 Reconstituted Complex physical 15225637 CSNK2A1 Affinity Capture-Western physical 12902976 SFN Affinity Capture-Western physical 11896572 CDKN1A Affinity Capture-Western physical 11896572 TP53 Affinity Capture-Western physical 11896572 BLM Affinity Capture-Western physical 15364958 BLM Co-localization physical 15364958 TP53 Co-localization physical 15364958 TP53BP1 Co-localization physical 15364958 XIAP Reconstituted Complex physical 14759516 ATM Protein-peptide physical 10608806 ATR Protein-peptide physical 10608806 PRKDC Protein-peptide physical 10608806 TP53 Affinity Capture-Western physical 11896572 PRKDC Reconstituted Complex physical 12756247 TIMELESS Affinity Capture-Western physical 15798197 CLSPN Reconstituted Complex physical 12766152 CLSPN Affinity Capture-Western physical 12766152 TP53 Biochemical Activity physical 12756247 XRCC6 Affinity Capture-Western physical 12756247 XRCC6 Affinity Capture-Western physical 12756247 XRCC5 Affinity Capture-Western physical 12756247 CDC25A Biochemical Activity physical 9278511 CDC25B Biochemical Activity physical 9278511 CDC25C Biochemical Activity physical 9278511 CDC25A Reconstituted Complex physical 9278511 CDC25B Reconstituted Complex physical 9278511 CDC25C Reconstituted Complex physical 9278511 CDC25A Biochemical Activity physical 12399544 CDC25A Biochemical Activity physical 18480045 MSH6 Affinity Capture-Western physical 20029092 MSH6 Affinity Capture-Western physical 20029092 MDM4 Biochemical Activity physical 16511572 NEK9 Affinity Capture-MS physical 20562859 POLA1 Affinity Capture-Western physical 19177015 MDM4 Biochemical Activity physical 16163388 CDC25C Biochemical Activity physical 17035231 CLSPN Reconstituted Complex physical 16963448 CLSPN Biochemical Activity physical 16963448 CLSPN Reconstituted Complex physical 16963448 MCPH1 Reconstituted Complex physical 16783362 CDC25C Biochemical Activity physical 16705183 XPO1 Reconstituted Complex physical 12676962 CDC25C Biochemical Activity physical 15705874 CDC25A Biochemical Activity physical 12759351 PCNA Affinity Capture-Western physical 18448427 DNMT1 Affinity Capture-Western physical 17991895 DNMT1 Affinity Capture-Western physical 17991895 DDB1 Affinity Capture-MS physical 19276361 DDB1 Affinity Capture-Western physical 19276361 CUL4A Affinity Capture-Western physical 19276361 UBC Affinity Capture-Western physical 19276361 FANCE Biochemical Activity physical 17296736 DNMT1 Affinity Capture-Western physical 20940144 USP7 Affinity Capture-Western physical 21845734 MEN1 Affinity Capture-Western physical 20969866 MEN1 Affinity Capture-Western physical 20969866 TP53 Biochemical Activity physical 10673501 UBC Affinity Capture-MS physical 17370265 HSP90AA1 Affinity Capture-Western physical 21566061