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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Jak2 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000186activation of MAPKK activityISO
GO:0006468protein phosphorylationIEA
GO:0006915apoptosisIDA
GO:0006915apoptosisIMP
GO:0006979response to oxidative stressISO
GO:0007165signal transductionIMP
GO:0007167enzyme linked receptor protein signaling pathwayIDA
GO:0007186G-protein coupled receptor protein signaling pathwayISO
GO:0007204elevation of cytosolic calcium ion concentrationISO
GO:0007243intracellular protein kinase cascadeIDA
GO:0007259JAK-STAT cascadeIDA
GO:0007259JAK-STAT cascadeIMP
GO:0007259JAK-STAT cascadeISO
GO:0007260tyrosine phosphorylation of STAT proteinIDA
GO:0007260tyrosine phosphorylation of STAT proteinIMP
GO:0007262STAT protein import into nucleusIDA
GO:0008284positive regulation of cell proliferationISO
GO:0008285negative regulation of cell proliferationIMP
GO:0008631induction of apoptosis by oxidative stressISO
GO:0008636activation of caspase activity by protein phosphorylationIDA
GO:0009755hormone-mediated signaling pathwayISO
GO:0010811positive regulation of cell-substrate adhesionISO
GO:0014068positive regulation of phosphatidylinositol 3-kinase cascadeIMP
GO:0016310phosphorylationIEA
GO:0016568chromatin modificationIEA
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0019221cytokine-mediated signaling pathwayIMP
GO:0019221cytokine-mediated signaling pathwayISO
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0022408negative regulation of cell-cell adhesionISO
GO:0030099myeloid cell differentiationIMP
GO:0030154cell differentiationIMP
GO:0030218erythrocyte differentiationIMP
GO:0030335positive regulation of cell migrationISO
GO:0031103axon regenerationISO
GO:0031959mineralocorticoid receptor signaling pathwayISO
GO:0032024positive regulation of insulin secretionISO
GO:0032496response to lipopolysaccharideIDA
GO:0032516positive regulation of phosphoprotein phosphatase activityISO
GO:0032731positive regulation of interleukin-1 beta productionISO
GO:0032760positive regulation of tumor necrosis factor productionIDA
GO:0033160positive regulation of protein import into nucleus, translocationISO
GO:0033194response to hydroperoxideISO
GO:0033209tumor necrosis factor-mediated signaling pathwayISO
GO:0034612response to tumor necrosis factorISO
GO:0035409histone H3-Y41 phosphorylationISO
GO:0035722interleukin-12-mediated signaling pathwayISO
GO:0042503tyrosine phosphorylation of Stat3 proteinISO
GO:0042508tyrosine phosphorylation of Stat1 proteinISO
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0042977activation of JAK2 kinase activityIDA
GO:0043065positive regulation of apoptosisIDA
GO:0043065positive regulation of apoptosisISO
GO:0043388positive regulation of DNA bindingISO
GO:0043392negative regulation of DNA bindingIDA
GO:0043526neuroprotectionISO
GO:0045429positive regulation of nitric oxide biosynthetic processISO
GO:0045597positive regulation of cell differentiationISO
GO:0045822negative regulation of heart contractionISO
GO:0046677response to antibioticISO
GO:0046777protein autophosphorylationIDA
GO:0046777protein autophosphorylationISO
GO:0048008platelet-derived growth factor receptor signaling pathwayISO
GO:0050727regulation of inflammatory responseISO
GO:0050729positive regulation of inflammatory responseISO
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIMP
GO:0050867positive regulation of cell activationISO
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISO
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processIDA
GO:0051770positive regulation of nitric-oxide synthase biosynthetic processISO
GO:0060333interferon-gamma-mediated signaling pathwayISO
GO:0060396growth hormone receptor signaling pathwayISO
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayIDA
GO:0060397JAK-STAT cascade involved in growth hormone signaling pathwayIMP
GO:0060399positive regulation of growth hormone receptor signaling pathwayIMP
GO:0061180mammary gland epithelium developmentIMP
GO:0070671response to interleukin-12ISO
GO:0097012response to granulocyte macrophage colony-stimulating factor stimulusNAS
cellular_component
GO:0005624membrane fractionISO
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005737cytoplasmISO
GO:0005737cytoplasmTAS
GO:0005829cytosolISO
GO:0005856cytoskeletonIEA
GO:0005901caveolaIDA
GO:0016020membraneIEA
GO:0016363nuclear matrixISO
GO:0045121membrane raftIDA
molecular_function
GO:0000166nucleotide bindingIEA
GO:0004672protein kinase activityIEA
GO:0004713protein tyrosine kinase activityIDA
GO:0004713protein tyrosine kinase activityIMP
GO:0004713protein tyrosine kinase activityISO
GO:0004715non-membrane spanning protein tyrosine kinase activityIEA
GO:0005102receptor bindingISO
GO:0005131growth hormone receptor bindingISO
GO:0005143interleukin-12 receptor bindingIPI
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008022protein C-terminus bindingISO
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GO:0016772transferase activity, transferring phosphorus-containing groupsIEA
GO:0019901protein kinase bindingISO
GO:0020037heme bindingISO
GO:0031702type 1 angiotensin receptor bindingISO
GO:0033130acetylcholine receptor bindingISO
GO:0035401histone kinase activity (H3-Y41 specific)ISO
GO:0042169SH2 domain bindingISO
GO:0042393histone bindingISO
GO:0043548phosphatidylinositol 3-kinase bindingISO
GO:0043560insulin receptor substrate bindingISO
GO:0051428peptide hormone receptor bindingISO

Protein-protein interaction details for Jak2 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
KitAffinity Capture-Westernphysical8611693
Stat3Affinity Capture-Westernphysical15143188
Socs3Affinity Capture-Westernphysical15143188