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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Jak2 (
Mus musculus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000186
activation of MAPKK activity
ISO
GO:0006468
protein phosphorylation
IEA
GO:0006915
apoptosis
IDA
GO:0006915
apoptosis
IMP
GO:0006979
response to oxidative stress
ISO
GO:0007165
signal transduction
IMP
GO:0007167
enzyme linked receptor protein signaling pathway
IDA
GO:0007186
G-protein coupled receptor protein signaling pathway
ISO
GO:0007204
elevation of cytosolic calcium ion concentration
ISO
GO:0007243
intracellular protein kinase cascade
IDA
GO:0007259
JAK-STAT cascade
IDA
GO:0007259
JAK-STAT cascade
IMP
GO:0007259
JAK-STAT cascade
ISO
GO:0007260
tyrosine phosphorylation of STAT protein
IDA
GO:0007260
tyrosine phosphorylation of STAT protein
IMP
GO:0007262
STAT protein import into nucleus
IDA
GO:0008284
positive regulation of cell proliferation
ISO
GO:0008285
negative regulation of cell proliferation
IMP
GO:0008631
induction of apoptosis by oxidative stress
ISO
GO:0008636
activation of caspase activity by protein phosphorylation
IDA
GO:0009755
hormone-mediated signaling pathway
ISO
GO:0010811
positive regulation of cell-substrate adhesion
ISO
GO:0014068
positive regulation of phosphatidylinositol 3-kinase cascade
IMP
GO:0016310
phosphorylation
IEA
GO:0016568
chromatin modification
IEA
GO:0018108
peptidyl-tyrosine phosphorylation
IDA
GO:0019221
cytokine-mediated signaling pathway
IMP
GO:0019221
cytokine-mediated signaling pathway
ISO
GO:0019221
cytokine-mediated signaling pathway
TAS
GO:0022408
negative regulation of cell-cell adhesion
ISO
GO:0030099
myeloid cell differentiation
IMP
GO:0030154
cell differentiation
IMP
GO:0030218
erythrocyte differentiation
IMP
GO:0030335
positive regulation of cell migration
ISO
GO:0031103
axon regeneration
ISO
GO:0031959
mineralocorticoid receptor signaling pathway
ISO
GO:0032024
positive regulation of insulin secretion
ISO
GO:0032496
response to lipopolysaccharide
IDA
GO:0032516
positive regulation of phosphoprotein phosphatase activity
ISO
GO:0032731
positive regulation of interleukin-1 beta production
ISO
GO:0032760
positive regulation of tumor necrosis factor production
IDA
GO:0033160
positive regulation of protein import into nucleus, translocation
ISO
GO:0033194
response to hydroperoxide
ISO
GO:0033209
tumor necrosis factor-mediated signaling pathway
ISO
GO:0034612
response to tumor necrosis factor
ISO
GO:0035409
histone H3-Y41 phosphorylation
ISO
GO:0035722
interleukin-12-mediated signaling pathway
ISO
GO:0042503
tyrosine phosphorylation of Stat3 protein
ISO
GO:0042508
tyrosine phosphorylation of Stat1 protein
ISO
GO:0042517
positive regulation of tyrosine phosphorylation of Stat3 protein
IDA
GO:0042523
positive regulation of tyrosine phosphorylation of Stat5 protein
IDA
GO:0042977
activation of JAK2 kinase activity
IDA
GO:0043065
positive regulation of apoptosis
IDA
GO:0043065
positive regulation of apoptosis
ISO
GO:0043388
positive regulation of DNA binding
ISO
GO:0043392
negative regulation of DNA binding
IDA
GO:0043526
neuroprotection
ISO
GO:0045429
positive regulation of nitric oxide biosynthetic process
ISO
GO:0045597
positive regulation of cell differentiation
ISO
GO:0045822
negative regulation of heart contraction
ISO
GO:0046677
response to antibiotic
ISO
GO:0046777
protein autophosphorylation
IDA
GO:0046777
protein autophosphorylation
ISO
GO:0048008
platelet-derived growth factor receptor signaling pathway
ISO
GO:0050727
regulation of inflammatory response
ISO
GO:0050729
positive regulation of inflammatory response
ISO
GO:0050731
positive regulation of peptidyl-tyrosine phosphorylation
IMP
GO:0050867
positive regulation of cell activation
ISO
GO:0051091
positive regulation of sequence-specific DNA binding transcription factor activity
ISO
GO:0051770
positive regulation of nitric-oxide synthase biosynthetic process
IDA
GO:0051770
positive regulation of nitric-oxide synthase biosynthetic process
ISO
GO:0060333
interferon-gamma-mediated signaling pathway
ISO
GO:0060396
growth hormone receptor signaling pathway
ISO
GO:0060397
JAK-STAT cascade involved in growth hormone signaling pathway
IDA
GO:0060397
JAK-STAT cascade involved in growth hormone signaling pathway
IMP
GO:0060399
positive regulation of growth hormone receptor signaling pathway
IMP
GO:0061180
mammary gland epithelium development
IMP
GO:0070671
response to interleukin-12
ISO
GO:0097012
response to granulocyte macrophage colony-stimulating factor stimulus
NAS
cellular_component
GO:0005624
membrane fraction
ISO
GO:0005634
nucleus
IDA
GO:0005634
nucleus
ISO
GO:0005737
cytoplasm
ISO
GO:0005737
cytoplasm
TAS
GO:0005829
cytosol
ISO
GO:0005856
cytoskeleton
IEA
GO:0005901
caveola
IDA
GO:0016020
membrane
IEA
GO:0016363
nuclear matrix
ISO
GO:0045121
membrane raft
IDA
molecular_function
GO:0000166
nucleotide binding
IEA
GO:0004672
protein kinase activity
IEA
GO:0004713
protein tyrosine kinase activity
IDA
GO:0004713
protein tyrosine kinase activity
IMP
GO:0004713
protein tyrosine kinase activity
ISO
GO:0004715
non-membrane spanning protein tyrosine kinase activity
IEA
GO:0005102
receptor binding
ISO
GO:0005131
growth hormone receptor binding
ISO
GO:0005143
interleukin-12 receptor binding
IPI
GO:0005515
protein binding
IPI
GO:0005524
ATP binding
IEA
GO:0008022
protein C-terminus binding
ISO
GO:0016301
kinase activity
IEA
GO:0016740
transferase activity
IEA
GO:0016772
transferase activity, transferring phosphorus-containing groups
IEA
GO:0019901
protein kinase binding
ISO
GO:0020037
heme binding
ISO
GO:0031702
type 1 angiotensin receptor binding
ISO
GO:0033130
acetylcholine receptor binding
ISO
GO:0035401
histone kinase activity (H3-Y41 specific)
ISO
GO:0042169
SH2 domain binding
ISO
GO:0042393
histone binding
ISO
GO:0043548
phosphatidylinositol 3-kinase binding
ISO
GO:0043560
insulin receptor substrate binding
ISO
GO:0051428
peptide hormone receptor binding
ISO
Protein-protein interaction details for Jak2 (
Mus musculus
)
(Information is obtained from BioGRID)
Interacting mouse protein
Experiment
Type
PubMed ID
Kit
Affinity Capture-Western
physical
8611693
Stat3
Affinity Capture-Western
physical
15143188
Socs3
Affinity Capture-Western
physical
15143188