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Gene
Protein
Transcript
Promoter
Expression
GO/PPI
PubMed
Cross reference
Gene Ontology information for Lef1 (
Mus musculus
)
(Information is obtained from AmiGO)
ID
Term
Evidence
biological_process
GO:0000122
negative regulation of transcription from RNA polymerase II promoter
IDA
GO:0001569
patterning of blood vessels
IMP
GO:0001649
osteoblast differentiation
IBA
GO:0001755
neural crest cell migration
IBA
GO:0001756
somitogenesis
IGI
GO:0001756
somitogenesis
IMP
GO:0001837
epithelial to mesenchymal transition
IMP
GO:0001944
vasculature development
IMP
GO:0002040
sprouting angiogenesis
IMP
GO:0006351
transcription, DNA-dependent
ISO
GO:0006355
regulation of transcription, DNA-dependent
IGI
GO:0006357
regulation of transcription from RNA polymerase II promoter
IDA
GO:0006366
transcription from RNA polymerase II promoter
IGI
GO:0006917
induction of apoptosis
IMP
GO:0008284
positive regulation of cell proliferation
ISO
GO:0010628
positive regulation of gene expression
ISO
GO:0010718
positive regulation of epithelial to mesenchymal transition
ISO
GO:0016055
Wnt receptor signaling pathway
IDA
GO:0016055
Wnt receptor signaling pathway
IGI
GO:0016055
Wnt receptor signaling pathway
IMP
GO:0016055
Wnt receptor signaling pathway
ISO
GO:0021542
dentate gyrus development
IMP
GO:0021766
hippocampus development
IMP
GO:0021854
hypothalamus development
IBA
GO:0021861
forebrain radial glial cell differentiation
IGI
GO:0021873
forebrain neuroblast division
IGI
GO:0021879
forebrain neuron differentiation
IBA
GO:0021943
formation of radial glial scaffolds
IGI
GO:0022407
regulation of cell-cell adhesion
IMP
GO:0022408
negative regulation of cell-cell adhesion
ISO
GO:0022409
positive regulation of cell-cell adhesion
ISO
GO:0030111
regulation of Wnt receptor signaling pathway
IGI
GO:0030223
neutrophil differentiation
IBA
GO:0030223
neutrophil differentiation
ISO
GO:0030307
positive regulation of cell growth
ISO
GO:0030326
embryonic limb morphogenesis
IGI
GO:0030335
positive regulation of cell migration
ISO
GO:0030509
BMP signaling pathway
IDA
GO:0030520
estrogen receptor signaling pathway
IBA
GO:0030520
estrogen receptor signaling pathway
ISO
GO:0030854
positive regulation of granulocyte differentiation
ISO
GO:0030879
mammary gland development
IMP
GO:0032696
negative regulation of interleukin-13 production
IBA
GO:0032696
negative regulation of interleukin-13 production
ISO
GO:0032713
negative regulation of interleukin-4 production
IBA
GO:0032713
negative regulation of interleukin-4 production
ISO
GO:0032714
negative regulation of interleukin-5 production
IBA
GO:0032714
negative regulation of interleukin-5 production
ISO
GO:0033153
T cell receptor V(D)J recombination
IGI
GO:0042100
B cell proliferation
IMP
GO:0042475
odontogenesis of dentine-containing tooth
IGI
GO:0042475
odontogenesis of dentine-containing tooth
IMP
GO:0043066
negative regulation of apoptosis
ISO
GO:0043154
negative regulation of caspase activity
IBA
GO:0043154
negative regulation of caspase activity
ISO
GO:0043392
negative regulation of DNA binding
ISO
GO:0043586
tongue development
IMP
GO:0043923
positive regulation by host of viral transcription
ISO
GO:0043966
histone H3 acetylation
ISO
GO:0043967
histone H4 acetylation
ISO
GO:0045063
T-helper 1 cell differentiation
IDA
GO:0045843
negative regulation of striated muscle tissue development
IDA
GO:0045892
negative regulation of transcription, DNA-dependent
IDA
GO:0045892
negative regulation of transcription, DNA-dependent
ISO
GO:0045893
positive regulation of transcription, DNA-dependent
IDA
GO:0045893
positive regulation of transcription, DNA-dependent
IMP
GO:0045893
positive regulation of transcription, DNA-dependent
ISO
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IDA
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
IMP
GO:0045944
positive regulation of transcription from RNA polymerase II promoter
ISO
GO:0046632
alpha-beta T cell differentiation
IGI
GO:0048069
eye pigmentation
IBA
GO:0048341
paraxial mesoderm formation
IGI
GO:0048468
cell development
IGI
GO:0048747
muscle fiber development
IBA
GO:0050909
sensory perception of taste
IMP
GO:0060021
palate development
IMP
GO:0060033
anatomical structure regression
IMP
GO:0060070
canonical Wnt receptor signaling pathway
IBA
GO:0060070
canonical Wnt receptor signaling pathway
ISO
GO:0060325
face morphogenesis
IGI
GO:0060326
cell chemotaxis
ISO
GO:0060561
apoptosis involved in morphogenesis
IMP
GO:0060710
chorio-allantoic fusion
IGI
GO:0061153
trachea gland development
IMP
GO:0071353
cellular response to interleukin-4
ISO
GO:0071864
positive regulation of cell proliferation in bone marrow
IBA
GO:0071864
positive regulation of cell proliferation in bone marrow
ISO
GO:0071866
negative regulation of apoptosis in bone marrow
IBA
GO:0071866
negative regulation of apoptosis in bone marrow
ISO
GO:0071895
odontoblast differentiation
IBA
GO:0071895
odontoblast differentiation
ISO
GO:0071899
negative regulation of estrogen receptor binding
ISO
GO:0090068
positive regulation of cell cycle process
ISO
GO:0090090
negative regulation of canonical Wnt receptor signaling pathway
ISO
cellular_component
GO:0005634
nucleus
IDA
GO:0005634
nucleus
ISO
GO:0005667
transcription factor complex
IPI
GO:0005667
transcription factor complex
ISO
GO:0005737
cytoplasm
IDA
GO:0005737
cytoplasm
ISO
GO:0032993
protein-DNA complex
ISO
molecular_function
GO:0003677
DNA binding
IDA
GO:0003682
chromatin binding
IDA
GO:0003700
sequence-specific DNA binding transcription factor activity
IDA
GO:0003700
sequence-specific DNA binding transcription factor activity
ISO
GO:0003705
sequence-specific distal enhancer binding RNA polymerase II transcription factor activity
IGI
GO:0005515
protein binding
IPI
GO:0008013
beta-catenin binding
IBA
GO:0008013
beta-catenin binding
ISO
GO:0008134
transcription factor binding
IPI
GO:0008301
DNA bending activity
IDA
GO:0030284
estrogen receptor activity
ISO
GO:0030331
estrogen receptor binding
IBA
GO:0030331
estrogen receptor binding
ISO
GO:0035326
enhancer binding
IBA
GO:0035326
enhancer binding
ISO
GO:0042393
histone binding
ISO
GO:0043027
caspase inhibitor activity
ISO
GO:0043565
sequence-specific DNA binding
IBA
GO:0043565
sequence-specific DNA binding
ISO
GO:0044212
transcription regulatory region DNA binding
IDA
GO:0044212
transcription regulatory region DNA binding
ISO
GO:0045295
gamma-catenin binding
IBA
GO:0045295
gamma-catenin binding
ISO
GO:0070016
armadillo repeat domain binding
IBA
GO:0070016
armadillo repeat domain binding
ISO
GO:0070742
C2H2 zinc finger domain binding
ISO
Protein-protein interaction details for Lef1 (
Mus musculus
)
(Information is obtained from BioGRID)
Interacting mouse protein
Experiment
Type
PubMed ID
Pias4
Two-hybrid
physical
20211142
Prop1
Phenotypic Suppression
genetic
16678101
Ctnnb1
Phenotypic Suppression
genetic
16678101
Pax3
Reconstituted Complex
physical
15729346
Tle4
Reconstituted Complex
physical
15729346
Axin2
Phenotypic Suppression
genetic
9554852