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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Lef1 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0000122negative regulation of transcription from RNA polymerase II promoterIDA
GO:0001569patterning of blood vesselsIMP
GO:0001649osteoblast differentiationIBA
GO:0001755neural crest cell migrationIBA
GO:0001756somitogenesisIGI
GO:0001756somitogenesisIMP
GO:0001837epithelial to mesenchymal transitionIMP
GO:0001944vasculature developmentIMP
GO:0002040sprouting angiogenesisIMP
GO:0006351transcription, DNA-dependentISO
GO:0006355regulation of transcription, DNA-dependentIGI
GO:0006357regulation of transcription from RNA polymerase II promoterIDA
GO:0006366transcription from RNA polymerase II promoterIGI
GO:0006917induction of apoptosisIMP
GO:0008284positive regulation of cell proliferationISO
GO:0010628positive regulation of gene expressionISO
GO:0010718positive regulation of epithelial to mesenchymal transitionISO
GO:0016055Wnt receptor signaling pathwayIDA
GO:0016055Wnt receptor signaling pathwayIGI
GO:0016055Wnt receptor signaling pathwayIMP
GO:0016055Wnt receptor signaling pathwayISO
GO:0021542dentate gyrus developmentIMP
GO:0021766hippocampus developmentIMP
GO:0021854hypothalamus developmentIBA
GO:0021861forebrain radial glial cell differentiationIGI
GO:0021873forebrain neuroblast divisionIGI
GO:0021879forebrain neuron differentiationIBA
GO:0021943formation of radial glial scaffoldsIGI
GO:0022407regulation of cell-cell adhesionIMP
GO:0022408negative regulation of cell-cell adhesionISO
GO:0022409positive regulation of cell-cell adhesionISO
GO:0030111regulation of Wnt receptor signaling pathwayIGI
GO:0030223neutrophil differentiationIBA
GO:0030223neutrophil differentiationISO
GO:0030307positive regulation of cell growthISO
GO:0030326embryonic limb morphogenesisIGI
GO:0030335positive regulation of cell migrationISO
GO:0030509BMP signaling pathwayIDA
GO:0030520estrogen receptor signaling pathwayIBA
GO:0030520estrogen receptor signaling pathwayISO
GO:0030854positive regulation of granulocyte differentiationISO
GO:0030879mammary gland developmentIMP
GO:0032696negative regulation of interleukin-13 productionIBA
GO:0032696negative regulation of interleukin-13 productionISO
GO:0032713negative regulation of interleukin-4 productionIBA
GO:0032713negative regulation of interleukin-4 productionISO
GO:0032714negative regulation of interleukin-5 productionIBA
GO:0032714negative regulation of interleukin-5 productionISO
GO:0033153T cell receptor V(D)J recombinationIGI
GO:0042100B cell proliferationIMP
GO:0042475odontogenesis of dentine-containing toothIGI
GO:0042475odontogenesis of dentine-containing toothIMP
GO:0043066negative regulation of apoptosisISO
GO:0043154negative regulation of caspase activityIBA
GO:0043154negative regulation of caspase activityISO
GO:0043392negative regulation of DNA bindingISO
GO:0043586tongue developmentIMP
GO:0043923positive regulation by host of viral transcriptionISO
GO:0043966histone H3 acetylationISO
GO:0043967histone H4 acetylationISO
GO:0045063T-helper 1 cell differentiationIDA
GO:0045843negative regulation of striated muscle tissue developmentIDA
GO:0045892negative regulation of transcription, DNA-dependentIDA
GO:0045892negative regulation of transcription, DNA-dependentISO
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentIMP
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIMP
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046632alpha-beta T cell differentiationIGI
GO:0048069eye pigmentationIBA
GO:0048341paraxial mesoderm formationIGI
GO:0048468cell developmentIGI
GO:0048747muscle fiber developmentIBA
GO:0050909sensory perception of tasteIMP
GO:0060021palate developmentIMP
GO:0060033anatomical structure regressionIMP
GO:0060070canonical Wnt receptor signaling pathwayIBA
GO:0060070canonical Wnt receptor signaling pathwayISO
GO:0060325face morphogenesisIGI
GO:0060326cell chemotaxisISO
GO:0060561apoptosis involved in morphogenesisIMP
GO:0060710chorio-allantoic fusionIGI
GO:0061153trachea gland developmentIMP
GO:0071353cellular response to interleukin-4ISO
GO:0071864positive regulation of cell proliferation in bone marrowIBA
GO:0071864positive regulation of cell proliferation in bone marrowISO
GO:0071866negative regulation of apoptosis in bone marrowIBA
GO:0071866negative regulation of apoptosis in bone marrowISO
GO:0071895odontoblast differentiationIBA
GO:0071895odontoblast differentiationISO
GO:0071899negative regulation of estrogen receptor bindingISO
GO:0090068positive regulation of cell cycle processISO
GO:0090090negative regulation of canonical Wnt receptor signaling pathwayISO
cellular_component
GO:0005634nucleusIDA
GO:0005634nucleusISO
GO:0005667transcription factor complexIPI
GO:0005667transcription factor complexISO
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISO
GO:0032993protein-DNA complexISO
molecular_function
GO:0003677DNA bindingIDA
GO:0003682chromatin bindingIDA
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityISO
GO:0003705sequence-specific distal enhancer binding RNA polymerase II transcription factor activityIGI
GO:0005515protein bindingIPI
GO:0008013beta-catenin bindingIBA
GO:0008013beta-catenin bindingISO
GO:0008134transcription factor bindingIPI
GO:0008301DNA bending activityIDA
GO:0030284estrogen receptor activityISO
GO:0030331estrogen receptor bindingIBA
GO:0030331estrogen receptor bindingISO
GO:0035326enhancer bindingIBA
GO:0035326enhancer bindingISO
GO:0042393histone bindingISO
GO:0043027caspase inhibitor activityISO
GO:0043565sequence-specific DNA bindingIBA
GO:0043565sequence-specific DNA bindingISO
GO:0044212transcription regulatory region DNA bindingIDA
GO:0044212transcription regulatory region DNA bindingISO
GO:0045295gamma-catenin bindingIBA
GO:0045295gamma-catenin bindingISO
GO:0070016armadillo repeat domain bindingIBA
GO:0070016armadillo repeat domain bindingISO
GO:0070742C2H2 zinc finger domain bindingISO

Protein-protein interaction details for Lef1 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Pias4Two-hybridphysical20211142
Prop1Phenotypic Suppressiongenetic16678101
Ctnnb1Phenotypic Suppressiongenetic16678101
Pax3Reconstituted Complexphysical15729346
Tle4Reconstituted Complexphysical15729346
Axin2Phenotypic Suppressiongenetic9554852