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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene Ontology information for Lrp6 (Mus musculus)
(Information is obtained from AmiGO)
IDTermEvidence
biological_process
GO:0001702gastrulation with mouth forming secondIGI
GO:0001756somitogenesisIGI
GO:0001843neural tube closureIGI
GO:0001843neural tube closureIMP
GO:0001933negative regulation of protein phosphorylationISO
GO:0001947heart loopingIGI
GO:0002009morphogenesis of an epitheliumIMP
GO:0002053positive regulation of mesenchymal cell proliferationIMP
GO:0003344pericardium morphogenesisIGI
GO:0003401axis elongationIMP
GO:0006355regulation of transcription, DNA-dependentISO
GO:0006469negative regulation of protein kinase activityISO
GO:0006897endocytosisIEA
GO:0007204elevation of cytosolic calcium ion concentrationISO
GO:0007268synaptic transmissionIBA
GO:0007268synaptic transmissionISO
GO:0007275multicellular organismal developmentIEA
GO:0009880embryonic pattern specificationIMP
GO:0009950dorsal/ventral axis specificationIMP
GO:0009952anterior/posterior pattern specificationIGI
GO:0009952anterior/posterior pattern specificationIMP
GO:0014029neural crest formationIBA
GO:0014029neural crest formationISO
GO:0014033neural crest cell differentiationISO
GO:0016055Wnt receptor signaling pathwayIGI
GO:0016055Wnt receptor signaling pathwayISO
GO:0016337cell-cell adhesionISO
GO:0021587cerebellum morphogenesisIMP
GO:0021794thalamus developmentIMP
GO:0021795cerebral cortex cell migrationIMP
GO:0021861forebrain radial glial cell differentiationIGI
GO:0021872forebrain generation of neuronsIMP
GO:0021874Wnt receptor signaling pathway involved in forebrain neuroblast divisionIGI
GO:0021874Wnt receptor signaling pathway involved in forebrain neuroblast divisionIMP
GO:0021915neural tube developmentIGI
GO:0021943formation of radial glial scaffoldsIGI
GO:0021987cerebral cortex developmentIMP
GO:0030178negative regulation of Wnt receptor signaling pathwayIGI
GO:0030326embryonic limb morphogenesisIGI
GO:0030900forebrain developmentIMP
GO:0030901midbrain developmentIMP
GO:0030917midbrain-hindbrain boundary developmentIMP
GO:0034392negative regulation of smooth muscle cell apoptosisISO
GO:0035108limb morphogenesisIGI
GO:0035108limb morphogenesisIMP
GO:0035115embryonic forelimb morphogenesisIGI
GO:0035115embryonic forelimb morphogenesisIMP
GO:0035116embryonic hindlimb morphogenesisIGI
GO:0035116embryonic hindlimb morphogenesisIMP
GO:0035121tail morphogenesisIGI
GO:0035121tail morphogenesisIMP
GO:0035261external genitalia morphogenesisIMP
GO:0042074cell migration involved in gastrulationIGI
GO:0042127regulation of cell proliferationIMP
GO:0042475odontogenesis of dentine-containing toothIMP
GO:0042733embryonic digit morphogenesisIGI
GO:0042733embryonic digit morphogenesisIMP
GO:0043065positive regulation of apoptosisIMP
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationIBA
GO:0044332Wnt receptor signaling pathway involved in dorsal/ventral axis specificationISO
GO:0045599negative regulation of fat cell differentiationIMP
GO:0045778positive regulation of ossificationIMP
GO:0045780positive regulation of bone resorptionIMP
GO:0045787positive regulation of cell cycleISO
GO:0045893positive regulation of transcription, DNA-dependentIDA
GO:0045893positive regulation of transcription, DNA-dependentISO
GO:0045944positive regulation of transcription from RNA polymerase II promoterIBA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISO
GO:0046849bone remodelingIGI
GO:0048596embryonic camera-type eye morphogenesisIMP
GO:0048699generation of neuronsIMP
GO:0048705skeletal system morphogenesisIMP
GO:0050680negative regulation of epithelial cell proliferationIMP
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIMP
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityISO
GO:0051593response to folic acidIMP
GO:0060021palate developmentIMP
GO:0060026convergent extensionIGI
GO:0060042retina morphogenesis in camera-type eyeIMP
GO:0060059embryonic retina morphogenesis in camera-type eyeIMP
GO:0060070canonical Wnt receptor signaling pathwayIGI
GO:0060070canonical Wnt receptor signaling pathwayIMP
GO:0060070canonical Wnt receptor signaling pathwayISO
GO:0060284regulation of cell developmentIMP
GO:0060325face morphogenesisIMP
GO:0060349bone morphogenesisIMP
GO:0060444branching involved in mammary gland duct morphogenesisIMP
GO:0060535trachea cartilage morphogenesisIGI
GO:0060596mammary placode formationIMP
GO:0060603mammary gland duct morphogenesisIGI
GO:0061310canonical Wnt receptor signaling pathway involved in cardiac neural crest cell differentiation involved in heart developmentIMP
GO:0061324canonical Wnt receptor signaling pathway involved in positive regulation of cardiac outflow tract cell proliferationIMP
GO:0071397cellular response to cholesterolISO
GO:0071542dopaminergic neuron differentiationIMP
GO:0071901negative regulation of protein serine/threonine kinase activityISO
GO:0090009primitive streak formationIGI
GO:0090118receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transportIMP
GO:0090244Wnt receptor signaling pathway involved in somitogenesisIMP
GO:0090245axis elongation involved in somitogenesisIGI
GO:0090263positive regulation of canonical Wnt receptor signaling pathwayISO
GO:2000051negative regulation of non-canonical Wnt receptor signaling pathwayIGI
GO:2000055positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specificationISO
GO:2000149negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesisIGI
GO:2000151negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesisIGI
GO:2000162negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesisIGI
GO:2000164negative regulation of planar cell polarity pathway involved in outflow tract morphogenesisIGI
GO:2000166negative regulation of planar cell polarity pathway involved in pericardium morphogenesisIGI
GO:2000168negative regulation of planar cell polarity pathway involved in neural tube closureIGI
cellular_component
GO:0005624membrane fractionIDA
GO:0005769early endosomeIDA
GO:0005783endoplasmic reticulumIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneIGI
GO:0005886plasma membraneISO
GO:0005901caveolaIBA
GO:0009986cell surfaceIBA
GO:0009986cell surfaceISO
GO:0016020membraneIEA
GO:0016021integral to membraneIEA
GO:0031410cytoplasmic vesicleISO
GO:0043025neuronal cell bodyIBA
GO:0043025neuronal cell bodyISO
GO:0043235receptor complexIBA
GO:0045202synapseIBA
GO:0045202synapseISO
molecular_function
GO:0004872receptor activityIEA
GO:0005041low-density lipoprotein receptor activityIBA
GO:0005041low-density lipoprotein receptor activityISO
GO:0005102receptor bindingISO
GO:0005109frizzled bindingISO
GO:0005515protein bindingIPI
GO:0015026coreceptor activityIBA
GO:0017147Wnt-protein bindingIPI
GO:0017147Wnt-protein bindingISO
GO:0019210kinase inhibitor activityISO
GO:0019534toxin transporter activityIMP
GO:0019534toxin transporter activityISO
GO:0034185apolipoprotein bindingIPI
GO:0042803protein homodimerization activityISO
GO:0042813Wnt-activated receptor activityIBA
GO:0071936coreceptor activity involved in Wnt receptor signaling pathwayISO

Protein-protein interaction details for Lrp6 (Mus musculus)
(Information is obtained from BioGRID)
Interacting mouse proteinExperimentTypePubMed ID
Cdh2Affinity Capture-Westernphysical19075000
Cdh2Phenotypic Suppressiongenetic19075000
Wnt1Affinity Capture-Westernphysical16126904
Wnt1Affinity Capture-Westernphysical16126904
Dkk1Affinity Capture-Westernphysical16126904
Dkk1Affinity Capture-Westernphysical16126904
mesdAffinity Capture-Westernphysical16126904
mesdAffinity Capture-Westernphysical16126904
Kremen2Affinity Capture-Westernphysical16126904
Kremen2Affinity Capture-Westernphysical16126904
Wnt5aAffinity Capture-Westernphysical19056682
Wnt5aAffinity Capture-Westernphysical19056682
Wnt5aPhenotypic Suppressiongenetic19056682
Wnt1Phenotypic Suppressiongenetic15143170